Urolithin A

April 8, 2021

Urolithin A ayaa loo soo bandhigay inuu kiciyo mitophagy iyo hagaajinta caafimaadka muruqyada ee xayawaanka duugga ah iyo moodooyinka hore ee gabowga. Dhanka kale, waxaa sidoo kale la muujiyay inay ka gudubto xayiraadda maskaxda dhiigga, waxaana laga yaabaa inay yeelato saameyn neuroprotective ah oo ka dhan ah Cudurka Alzheimers.

Urolithin A (1143-70-0)sooc

Product Name Urolithin A budada
Magaca Kiimikada 3,8-dihydroxy-6H-benzo [c] chromen-6-mid;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-mid;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-mid;

6H-Dibenzo [b, d] pyran-6-one, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number 1143-70-0
InChikey RIUPLDUFZCXCHM-UHFFFAOYSA-N
dhoola C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Molecular Formula C13H8O4
Molecular Wsideed 228.2 g / mol
Monoisotopic Mass 228.042259 g / mol
barta barafku 340-345 ° C
dhibic kulayl  527.9 ± 43.0 ° C (Saadaaliyay)
flash Point 214.2ºC
Biological Life-Life Urolithin A wuxuu ku jiraa kaadi ilaa 48 saacadood ka dib cabitaanka casiirka rummaanka.
Color Caddaan beige
SOlubility  DMSO: 20 mg / mL, cad
Storage Temperature  2-8 ° C
Application Waxaa loo adeegsadaa kaabis cunto iyo wax soo saarka gabowga, waxaa loo isticmaali karaa yareynta caabuqa iyo la dagaallanka kansarka;

 

Tixraaca:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Saamiga Dheef-shiid kiimikaadka ee Ellagitannins: Saamaynta Caafimaadka, iyo Aragtida Cilmi-baarista ee Cunnooyinka Wax-ku-oolka ah ee Wax-ku-oolka ah". Faallooyinka halista ah ee Sayniska Cuntada iyo Nafaqada. 54 (12): 1584–1598. doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A wuxuu kiciyaa mitophagy wuxuuna sii dheereeyaa cimriga C. elegans wuxuuna kordhiyaa shaqada muruqyada jiirka. Nat. Med. 22, 879–888 (2016).

[3] "Ogeysiiska FDA GRAS GRN No. 791: urolithin A". Maamulka Cuntada iyo Dawooyinka ee Mareykanka. 20 Diseembar 2018. Waxaa dib loo helay 25 Ogosto 2020.

[4] Singh, A .; Andreux, P.; Blanco-Bose, W .; Ryu, D .; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Urolithin A ee afka laga qaato ayaa amaan ah waxayna wax ka bedeshaa muruqyada iyo mitokondria biomarkers-ka dadka da'da ah". Cusbooneysiinta da'da. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Qiimeynta amniga ee urolithin A, dheef-shiid kiimikaad ah oo ay soo saarto bini-aadanka mindhicirka bini'aadamka marka la cuno cunnooyinka dhirta laga helo" ellagitannins iyo ellagic acid ". Cuntada iyo Kiimikada Kiimikada. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.