Budada NMN (1094-61-7)

October 30, 2018

Warshadeenu waxay awood u leedahay inay soo saarto wax ka badan 1370kg Nicotinamide Mononucleotide (nmn) budada bishiiba marka loo eego xaaladaha GMP.


Status: Wax soosaarka Mass
Unugga: 25kg / Drum
Capacity: 1370kg / bishii

Nicotinamide Mononucleotide (NMN) (1094-61-7) fiidiyow

 

NMN Powder (1094-61-7) Sooc

Product Name Root Nicotinamide Mononucleotide (NMN) budada
Magacyo la macno ah NAMN, β-NMN, β-Nicotinamide Mononucleotide ama Beta Nicotinamide Mononucleotide; NMN;

beta-NMN

Fasalka Daroogada Kaalmada cuntada
CAS Number 1094-61-7
InChikey DAYLJWODMCOQEW-TURQNECASA-N
Foomka Molecular C11H15N2O8P
Miisaanka Molecular 334.22 g / mol
Monoisotopic Mass 334.056602 g / mol
Barta Dhalaalka  166 ° C (dec.)
Bar baraf N / A
Biological Life-Life N / A
Color Caddaan cad-cad-cad
milmi  Beta-NMN waxaa loo bixiyaa sidii dhagax adag. Beta-NMN si tartiib tartiib ah loogu dhex milmi karo dareeraha dareeraha sida ethanol, DMSO, iyo dimethyl formamide. Tijaabooyinka bayoolojiga ah, waxaan soo jeedineynaa in xalalka aqueous-bilaashka ah ee Beta-NMN loo diyaariyo iyadoo si toos ah loo kala dirayo dhagxaanta adag ee ku jirta keydka biyaha. Xakamaynta Beta-NMN ee PBS, pH 7.2, waa qiyaastii 10 mg / ml. Kuma talineyno inaad keydiso xalka biyaha ka badan hal maalin.
Heerkulka Kaydinta  Qolka temperatur;

Ku kaydi -20 ° C ilaa 2 sano.

Codsiga Ka-hortagga gabowga cuntada

 

Taariikhda NMN

Nicotinamide mononucleotide (qaaciddada maadada: C11H15N2O8P, lambarka CAS: 1094-61-7, oo sidoo kale loo yaqaan NMN, beta-Nicotinamide mononucleotide ama β-NMN) waa fitamiin B3 dheef-shiid kiimikaad [1], oo si dabiici ah looga helo jirka bini-aadamka, isla markaana ay wadaagaan cuntooyinka sida broccoli iyo kaabash qadar yar [2].

NMN waxay bilawday inay xiiso u hesho kaabis ahaan nafaqo oo macquul ah sanadkii 2013, ka dib daraasad horumar leh oo ay sameeyeen saynisyahano Harvard ah oo ku saabsan jiirka [3,4].

NMN waxaa markii ugu horreysay loo soo saaray kaabis xagga aadanaha ah sanadkii 2015 [5], laakiin waxay ahayd mid aad qaali u ah soo saaristeeda, illaa laga soo saaray habab lagu yareynayo kharashka wax soo saarka isla markaana loo kordhinayo daahirnimada 2018 [6], xilligaas oo sheybaarro loogu talo galay wax soo saarka ballaaran ay bilaabeen inay kaalay internetka.

 

Waa maxay budada NMN?

Nicotinamide mononucleotide (qaaciddada maadada: C11H15N2O8P, lambarka CAS: 1094-61-7, oo sidoo kale loo yaqaan NMN, beta-Nicotinamide mononucleotide ama β-NMN) waa fitamiin B3 dheef-shiid kiimikaad [1], oo si dabiici ah looga helo jirka bini-aadamka, isla markaana ay wadaagaan cuntooyinka sida broccoli iyo kaabash qadar yar [2].

Nicotinamide Mononucleotide (NMN) waa iskudhaf dabiici ah oo ku dhaca qaddar yar jidhka bini'aadamka iyo sidoo kale cuntooyinka qaarkood. NMN hadal ahaan waa la heli karaa, marka afka laga qaato waxay taageeri kartaa heerarka NAD + ee ku jira beerka iyo unugyada muruqyada.

Cilmi-baaristii ugu dambeysay waxay soo jeedisay in NMN ay taageeri karto caafimaadka wadnaha, wax soo saarka tamarta, caafimaadka garashada, iyo sidoo kale caafimaadka isha iyo lafaha. Mid ka mid ah raadinta xiisaha leh ee cilmi-baarista NMN ayaa ah inay dhiirrigelin karto hagaajinta DNA-da ayna taageerto firfircoonida hiddo-wadayaasha SIRTUIN ee loo maleynayo inay door ka ciyaarayaan gabowga caafimaadka qaba.

 

Sidee buu u shaqeeyaa Nicotinamide mononucleotide (NMN)?

NMN waa horudhac u ah NAD + molecule; jidhka bini'aadamku wuxuu u baahan yahay NMN si uu u sameeyo NAD + u gaar ah.

NAD + waa qaabka oksijiin ee NAD (Nicotinamide adenine dinucleotide), molecule markii uguhoreysay laga helay 1906, lagana helay dhamaan unugyada nool [7].

Kordhinta NAD + lafteeda ikhtiyaar uma ahan in kor loo qaado heerarka NAD +, maxaa yeelay waa wax aad u weyn in si fudud loo gudbo xuubyada unugyada si ay u galaan unugyada, sidaa darteedna aysan awoodin inay si togan u saameeyaan dheef-shiid kiimikaadka [8].

 

Waa Maxay Nicotinamide mononucleotide (NMN) Wanaagsan? Faa'iidooyinka budada NMN.

Hal dariiqo oo aan ku sii wadi karno heerarka caafimaad ee NAD + waa iyada oo lagu kaabayo jirkeenna horudhac ahaan, nicotinamide mononucleotide (NMN).

Cilmi-baarista hadda jirta waxay muujineysaa in is-beddelkan u dhexeeya NR iyo NMN ay tahay inuu u dhaco gelitaanka dhowr nooc oo unug ah. Tani waxay u horseedaa cilmi-baarayaasha inay aaminaan in NMN ay tahay, dhab ahaantii, mid ka mid ah hababka ugu dhaqsaha badan ee lagu kiciyo wax soo saarka NAD. Si kastaba ha noqotee, budada 'Nicotinamide mononucleotide' waxay sidoo kale cadeyneysaa inay leedahay faa'iidooyin kahortaga gabowga oo ka baxsan kuwa wax soo saarka NAD oo keliya.

Marka lagu daro dariiqa dheef-shiid kiimikaadka NAD, budada NMN waxaa si toos ah loogu dari karaa unugyada iyadoo aan loo beddelin NAD. Dhacdadan waxaa suurto galiyay borotiinno gaadiid oo dhowaan la helay kuwaas oo sii kordhaya kadib markii heerarka NAD hoos u dhacaan. Foomkan, NMN waxay gacan ka geysaneysaa tamarta unugyada waxayna u oggolaaneysaa mid kasta oo ka mid ah astaamaha horay loo soo sheegay ee anti-gabowga ee lagu dhiirrigeliyo unugyada leh awood ku filan oo ay ku koraan oo dib ugu soo noolaadaan.

Xulashada in lagu daro budada NMN oo ay weheliso NAD waxay bixisaa waddo toos ah oo toos ah oo loogu talagalay kor u qaadista dheef-shiid kiimikaadka sidaas awgeedna waa hab dhaqso badan oo isla sidaas lagu sameeyo. Intaa waxaa dheer, budada Nicotinamide mononucleotide ayaa la helay si loo hagaajiyo waxqabadka insulin iyo wax soo saarka, taasoo keentay faa'iidooyin dheef-shiid kiimikaad oo dheeri ah iyo sidoo kale dulqaadka gulukooska. Gaar ahaan, kaabisyada NMN waxay kaa caawin karaan shaqada si loo yareeyo xaaladaha dheef-shiid kiimikaadka sida sonkorowga, cudurka beerka dufanka badan, iyo cayilka. [11]

 

Faa'iidooyinka kale ee Waxtarka leh ee NMN

  • Waxay sare u qaadaa caafimaadka xididdada dhiigga iyo socodka dhiigga. [11]
  • Waxay wanaajisaa adkeysiga murqaha iyo xoogga
  • Wuxuu Kahortagaa Cudurka Wadnaha
  • Waxay yareysaa halista cayilka. [10]
  • Waxay wanaajisaa Dayactirka Dayactirka DNA
  • Kordhinta Shaqada Mitochondrial. [9]

 

Sidee loo helaa xasillooni, nadiif, badbaado leh NMN?

Si loo go'aamiyo sida lagu gaari karo wax soo saar xasiloon, dhab ah, saafi ah oo ammaan ah, taxane tijaabooyin iyo falanqeyn ah ayaa la sameeyay. Warbixinta COA, HPLC iyo HNMR ayaa la bixin karaa.

 

Deganaansho la wanaajiyey

Iyadoo la falanqeynayo qaab dhismeedka 'Nicotinamide mononucleotide' oo la adeegsanayo wareejinta lacag bixinta iyo habka kormeerka FTIR ee gudaha, waxaa la ogaadey in NMN ay leedahay hal qaab dhismeed cusbo ah iyo barta isoelectric ee cusbada gudaha waa qodobka ugu muhiimsan ee xasillooni darrada NMN. Biyaha, oo ah hal mecole, waxay kicin doontaa wareejinta korantada ee ku jirta NMN taas oo burburin karta qalfoofka milixda ee xasilloon ee NMN. Hadday sidaas tahay, NMN waxay soo bandhigi doontaa qaab-dhismeed kala-wareejin qiyaaseed oo si fudud u duleeya, kuwaas oo ka kooban biyaha ku jira badeecada iyo molikuyuullada biyaha ee bilaashka ah ee hawada waxay si toos ah u baabi'inayaan barta istelectric ee cusbada gudaha waxayna hoos u dhigaysaa nadiifnimada NMN. Tani waa guul weyn oo laga gaadhay baaritaanka xasiloonida budada NMN, taas oo noqon doonta mid bilow ah oo lagu horumariyo.

Si loo wanaajiyo xasilloonida budada NMN gudaha, cilmi baarayaashu waxay si hal abuurnimo leh u soo saareen budo cusub oo loo yaqaan 'NMN budada' oo leh habeyn yar oo nidaamsan oo isafgarad leh.

 

Xasilooni ka xoog badan, nolol dheer.

Budada Phcoker NMN waa nidaam iyo iswaafajin, si wax ku ool ah u xakameysa xiriirka biyaha bilaashka ah ee hawada, taas oo si weyn u kordhineysa xasiloonida NMN iyo kordhinta nolosha shelf ee badeecada. Ka soo horjeedka sheeko-soo-saarka 'NMN microscopic', qaab dhismeedka jiilka kowaad wuxuu muujinayaa khalkhal badan iyo hawlgal la'aan, sidaas darteed mokil kasta wuxuu helayaa soo-gaadhis badan oo hawo ah isla markaana biyo badan soo dhuuqaya.

 

Cufnaanta sare, qiyaasta xasiloonida badan iyo qaabaynta dabacsan.

Budada NMN oo leh nidaam nidaamsan oo isku dhafan oo ciriiri ah ayaa leh cufnaan badan iyo dheecaan, taas oo ka hortageysa qiyaasta aan degganeyn sababtoo ah kor u qaadista boodhka habka diyaarinta. Maxaa intaa ka sii badan, waxay saameyn ku yeelan doontaa qiyaasta lebbiska isku midka ah ee kaabsoosha. Dhanka kale, maadaama ay leedahay dheecaan wanaagsan, Budadayada NMN waxay kaa caawin kartaa yareynta muddada wax soo saarka iyo qiimaha wax soo saarka inta lagu jiro wax soo saarka.

 

Dammaanad tayo sare leh oo saafi ah

Warbixinta baaritaanka sheybaarka saddexaad waa inay noqdaan lagama maarmaan si loo xaqiijiyo aqoonsiga iyo nadiifnimada NNM. Qayb kasta oo ka mid ah alaabta ceeriin waa inay ku aflaxaan is-kormeer adag iyo baaritaan dhinac saddexaad ah. Warbixinta baaritaanka HNMR iyo HPLC waxay sii xaqiijin kartaa xaqiiq ahaanta, tayada sare iyo nadiifnimada NMN.

 

Phcoker waa soo saaraha budada Nicotinamide mononucleotide (NMN)

Iyada oo leh warshad iskaa ah, soosaarkayaga budada ah ee loo yaqaan 'NMN budada' ee billaha ah wuxuu gaarayaa in ka badan 2 tan

 

Codsiga budada NMN

Qalabka ceeriin ee qurxinta:

NMN waa walax ka mid ah jirka unugyada, NMN-na waa monomer molecule , waa saameyn anti-gabowga waa wax iska cad, sidaas darteed waxaa loogu isticmaali karaa alaabada ceeriin ee la isku qurxiyo.

 

Alaabada daryeelka caafimaadka:

Budada NMN waxaa lagu diyaarin karaa khamiirka khamiirka, isku-darka kiimikada ama catrosta enzymatic catalysis.

Budada NMN ayaa si ballaaran loogu isticmaalay warshadaha daryeelka caafimaadka.

 

Tixraaca:

[1] Nicotinamide mononucleotide. Laga soo bilaabo Wikipedia, encyclopedia bilaash ah. 2019.

[2] Maamulka Muddada-Dheer ee Nicotinamide Mononucleotide Mitigates Hoos u Dhaca Jirka Jirka ee Hoosudhaca. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Qalabka Metab. 2016 Diisembar 13.

[3] Hoos u dhaca NAD + wuxuu kiciyaa Dawlad been abuur ah oo carqaladeysa Isgaarsiinta Nuclearka-Mitochondrial inta lagu jiro Da'da. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Qolka. 2013 Dec 19; 155 (7): 1624-38. doi: 10.1016 / j.cell.2013.11.037.

[4] Sababo Waayeel Ah-Oo Dib Looga Noqon Karo. David Cameron. Dugsiga Caafimaadka Harvard, News & Research, Diseembar 19, 2013

[5] Jeebka NAD + ee kuxiran ee xakameynaya isdhexgalka borotiinka-borotiinka inta lagu jiro da'da. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Sayniska. 2017 Mar 24; 355 (6331): 1312-1317. doi: 10.1126 / science.aad8242.

[6] Habka Ka-saarista Chromatography Habka Daahirinta Nicotinamide Mononucleotide (NMN) oo laga helo Unugyada Bakteeriyada. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Warbixinno cilmiyeed Qaybtii 8aad, Maqaalka nambarkiisa: 4433 (2018).

[7] Nicotinamide adenine dinucleotide. Laga soo bilaabo Wikipedia, encyclopedia bilaash ah. 2019.

[8] Aqoonsiga gawaadhida mitochondrial NAD + ee loo yaqaan 'Saccharomyces cerevisiae', Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Jannaayo 20; 281 (3): 1524-31. Epub 2005 Nofeembar 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Cadaadiska Oxidative iyo Nidaamka Kynurenine, oo diirada saaraya Gabowga iyo Neuroprotection. Molecules, 2018; DOI: 10.3390 / molecules23010191.

[10] Kaabista Nicotinamide mononucleotide (NMN) waxay hagaajineysaa saameynta buurnida hooyada ee jiirka: isbarbardhiga jimicsiga Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, oo ah Furaha NAD + Dhexe, wuxuu daaweeyaa Pathophysiology ee Cuntada- iyo Cudurka Sonkorowga Da'da Yar ee Jiirka. Qalabka Metab, 2011; DOI: 10.1016 / j.cmet.2011.08.014.

[12] Dawooyinka La-dagaallanka Da'da ee ugu dambeeyay: Nicotinamide Mononucleotide (NMN)