Nikotinamide adenine dinucleotide (53-84-9)

March 15, 2020

Nicotinamide adenine dinucleotide (NAD) waa isku-duwaha caawiya dheef-shiid kiimikaadka laga helo dhammaan unugyada nool. Waxay ku jirtaa laba nooc …….

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Nicotinamide adenine dinucleotide (53-84-9) fiidiyaha

Nicotinamide adenine dinucleotide (53-84-9) Smamnuucista

Product Name Nicotinamide adenine dinucleotide (NAD +)
Magaca Kiimikada Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChikey BAWFJGJZGIEFAR-NNYOXOHSSA-N
dhoolla caddayntaada C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Formula kelli C21H27N7O14P2
Miisaanka kelli 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Dhibicda Biyaha 160 ° C (320 ° F; 433 K)
Color White
Skulayl daran 2-8 ° C
milmi H2O: 50 mg / mL
Codsiga Cunto caafimaad, qurxinta, wax ku darista quudinta

 

waa maxay Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) waa cofactor caawiya dheef-shiid kiimikaadka laga helo dhammaan unugyada nool. Waxay kujirtaa laba qaab, oxidized (NAD +) iyo dhimis (NADH).

Coenzyme NAD +, oo ah nooca loo yaqaan 'oxidized form of NAD', ayaa markii ugu horraysay la ogaaday sanadkii 1906 dhakhaatiirta cilmiga noolaha ee Ingiriiska Arthur Harden iyo William John Young. NAD + waxaa isku dhafan laba waddo oo dheef-shiid kiimikaad, kuwaas oo laga soo saari karo 'de novo amino acid way', ama waxaa lagu soo saari karaa dib-u-warshadaynta qaybaha horay loo sameeyay (sida nicotinamide) dib loogu soo celiyo wadada badbaadada ee NAD +. Waa aaladda loo yaqaan 'pyridine nucleotide' oo muhiim u ah isku-darka aasaasiga ah isla markaana u adeegta unugyo badan oo muhiim ah unugyada unugyada ee ku lug leh taranka 'oxidative phosphorylation' iyo waxsoosaarka ATP, hagaajinta DNA, qaanuunka epigenetic ee muujinta hidda-wadaha, calaamadaynta kalsiyumka unugyada gacanta iyo shaqada Immunological.

NAD + waa moodeelka ugu weyn ee aqbala koronto-dhaliye ee cilmiyaysan noolaha. Waxay ka aqbashaa elektaroonikyada moleekulada kale waana la dhimay. Waxay sidoo kale u shaqeysaa sidii coenzyme ee wareejinta hydride-ka iyo qeyb kale oo cunaysa NAD (+) polymerase, waxayna sameysaa isku-darka coenzyme redox oo leh 'reduced-nicotinamide adenine dinucleotide' (NADH). NAD (R) waa ADP-ribose deeq-bixiye unugyada ribosylation ee ADP-A. Waxay kaloo hordhac u tahay baaskiil ADP-ribose (ADP-ribosyl cyclase).

Maaddaama ay tahay oksaydh ku jira dheef-shiid kiimikaadka, NAD (R) sidoo kale wuxuu door ka ciyaaraa falcelinta wareejinta adenosine diphosphate (ADP) -rebose ee ku lug leh diadenylate (ADP-ribose) polymerase iyo dhowr geeddi-socodka enzymatic. Waxay si ka hortag ah u siin kartaa NAD si looga hortago ama loo yareeyo sonkorowga, kansarka iyo cudurrada kale ee la xiriira da'da. Sidoo kale, dhiirrigeliyeyaasha 'NAD +' waxay u wada shaqeyn karaan si iskudhafan oo dheeri ah sida resveratrol si ay uga caawiso dib-u-cusbooneysiinta mitokondria iyo la dagaallanka cudurrada gabowga.

 

Nicotinamide adenine dinucleotide(NAD +) dheefaha

Maaddaama uu yahay waxtarka oksidheer, Nikotinamide adenine dinucleotide wuxuu muujinayaa in xoogaa faa'iidooyin ah ay u leeyihiin howlaha aadanaha.

U-hagaaji howlahaaga gacanta,

Naturally Kordhi tamartaada si dabiici ah;

Hagaajinta shaqada maskaxda, diiradda iyo xusuusta;

Kordhi dheef-shiid kiimikaadkaaga;

Sleep Hagaajinta hurdada;

St Kordhi waxqabadka sirtuin caalami ah;

Hagaajinta waxtarka antioxidant;

Inflammation Yaree caabuqa;

Balance Dheelitirnaan, niyadda, aragga iyo maqalka oo hagaagay;

Nicotinamide adenine dinucleotid sidoo kale waa bartilmaameedka tooska ah ee dawada isoniazid, taas oo loo isticmaalo daaweynta qaaxada, infekshan uu sababo cudurka qaaxada Mycobacterium. Hal tijaabo, jiir la siiyay NAD hal toddobaad ayaa hagaajiyay isgaarsiinta nukliyeerka-mitochrondrial.

Intaa waxaa sii dheer, Nicotinamide adenine dinucleotide (NAD +) ayaa sidoo kale leh ka hortagga iyo daaweynta xannibaadda wadnaha, shaqada sanka iyo shaqada tijaabada dhakhsaha ah ee jimicsiga, nicotinamide waxay si weyn u wanaajin kartaa heerka garaaca wadnaha iyo xannibaadda loo yaqaan 'Atriove ntricular block' oo sababay verapamil.

 

Nicotinamide adenine dinucleotide(NAD +) Codsiga:

  1. Baadhitaannada cilladaha ee loo adeegsado agab cayriin ah, tijaabooyin cilmi-baaris cilmi ah.
  2. Cunto caafimaad, qurxinta, wax ku darista quudinta
  3. Wax soo saarka API

 

More Nicotinamide adenine dinucleotide(NAD +) cilmi baaris

Enzymes-ka sameeya isla markaana adeegsada NAD + iyo NADH ayaa muhiim u ah labadaba farmasiga iyo baaritaanka daaweynta mustaqbalka ee cudurada. Daawada loo yaqaan 'coenzyme NAD +' lafteeda lafteeda hadda looma isticmaalin daaweyn cudur kasta. Si kastaba ha noqotee, waxaa loo darsay isticmaalkeeda suurtagalka ah ee daaweynta cudurada neerfaha ku dhaca sida cudurka Alzheimers iyoParkinson.

 

Tixraaca:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + dheef-shiid kiimikaad caafimaad iyo cudur" (PDF). Isbeddellada Biochem. Sayniska. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Waxaa laga keydiyay asalka (PDF) 4 julay 2009. Waxaa lagahelay 23 December 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Aqoonsiga mitochondrial NAD + ee qaada xamuulka Saccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Abriil 2003). "Nicotinamide adenine dinucleotide, oo ah jaangooyaha dheef-shiid kiimikaadka ee qoraalka, cimri dherer iyo cudur". Curr. Opin Qalabka Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Xaaladda redox ee nicotinamide-adenine dinucleotide bilaash ah ee cytoplasm iyo mitochondria ee beerka jiirka". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Maarso 1980). "Nicotinamide adenine dinucleotide biosynthesis iyo pyridine nucleotide cycle metabolism ee nidaamyada microbial". Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Faransiiska SW. Xannibaadda qamriga ee joogtada ahi waxay dhaawacdaa beerka iyo xubnaha kale iyada oo la yareeyo heerarka NAD⁺ ee looga baahan yahay waxqabadka deacetylase ee sirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins iyo NAD + ee Horumarinta iyo Daaweynta Cudurrada Macdanta iyo Wadnaha. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.