Nikotinamide adenine dinucleotide (53-84-9)

March 15, 2020
SKU: 53-84-9
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Nicotinamide adenine dinucleotide (NAD) waa cofactor caawiya dheef-shiid kiimikaadka laga helo dhammaan unugyada nool. Waxay u jirtaa laba qaab …….


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Nicotinamide adenine dinucleotide (53-84-9) fiidiyaha

Nicotinamide adenine dinucleotide (53-84-9) Smamnuucista

Product Name Nicotinamide adenine dinucleotide (NAD +)
Magaca Kiimikada Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChikey BAWFJGJZGIEFAR-NNYOXOHSSA-N
dhoolla caddayntaada C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Formula kelli C21H27N7O14P2
Miisaanka kelli 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Dhibicda Biyaha 160 ° C (320 ° F; 433 K)
Color White
Skulayl daran 2-8 ° C
milmi H2O: 50 mg / mL
Codsiga Cunto caafimaad, qurxinta, wax ku darista quudinta

waa maxay Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) waa cofactor caawiya dheef-shiid kiimikaadka laga helo dhammaan unugyada nool. Waxay kujirtaa laba qaab, oxidized (NAD +) iyo dhimis (NADH).

Coenzyme NAD +, oo ah nooca loo yaqaan 'oxidized form of NAD', ayaa markii ugu horraysay la ogaaday sanadkii 1906 dhakhaatiirta cilmiga noolaha ee Ingiriiska Arthur Harden iyo William John Young. NAD + waxaa isku dhafan laba waddo oo dheef-shiid kiimikaad, kuwaas oo laga soo saari karo 'de novo amino acid way', ama waxaa lagu soo saari karaa dib-u-warshadaynta qaybaha horay loo sameeyay (sida nicotinamide) dib loogu soo celiyo wadada badbaadada ee NAD +. Waa aaladda loo yaqaan 'pyridine nucleotide' oo muhiim u ah isku-darka aasaasiga ah isla markaana u adeegta unugyo badan oo muhiim ah unugyada unugyada ee ku lug leh taranka 'oxidative phosphorylation' iyo waxsoosaarka ATP, hagaajinta DNA, qaanuunka epigenetic ee muujinta hidda-wadaha, calaamadaynta kalsiyumka unugyada gacanta iyo shaqada Immunological.

NAD + waa moodeelka ugu weyn ee aqbala koronto-dhaliye ee cilmiyaysan noolaha. Waxay ka aqbashaa elektaroonikyada moleekulada kale waana la dhimay. Waxay sidoo kale u shaqeysaa sidii coenzyme ee wareejinta hydride-ka iyo qeyb kale oo cunaysa NAD (+) polymerase, waxayna sameysaa isku-darka coenzyme redox oo leh 'reduced-nicotinamide adenine dinucleotide' (NADH). NAD (R) waa ADP-ribose deeq-bixiye unugyada ribosylation ee ADP-A. Waxay kaloo hordhac u tahay baaskiil ADP-ribose (ADP-ribosyl cyclase).

Maaddaama uu yahay maadiyaha 'metabolism' ee dheef-shiid kiimikaadka, NAD (R) wuxuu kaloo door ku leeyahay adenosine diphosphate (ADP) -rebose fal-celinta oo ku lug leh diadenylate (ADP-ribose) polymerase iyo dhowr kale oo enzymatic ah. Waxay ka hortag u siin kartaa NAD si looga hortago ama loo yareeyo sonkorowga, kansarka iyo cudurrada kale ee la xiriira da'da. Sidoo kale, kor u qaadista NAD + ayaa laga yaabaa inay si isku mid ah ula shaqeeyaan kaabayaasha sida resveratrol si looga caawiyo dib u soo noolaynta mitochondria iyo la dagaallanka cudurada gabowga.

Nicotinamide adenine dinucleotide(NAD +) dheefaha

Maaddaama uu yahay waxtarka oksidheer, Nikotinamide adenine dinucleotide wuxuu muujinayaa in xoogaa faa'iidooyin ah ay u leeyihiin howlaha aadanaha.

Kor u qaad firfircoonidaada gacanta,

Kordhinta tamartaada si dabiici ah;

Hagaajinta shaqada maskaxda, diiradda iyo xusuusta;

Kordhinta dheef-shiid kiimikaadkaaga;

Sleep Hagaajinta hurdada;

♦ Kordhi firfircoonaanta sirtuin caalami ah;

Hagaajinta waxtarka antioxidant;

♦ Hoos u dhig caabuqa;

Balance Isu-dheellitirnaan wanaagsan, niyadda, aragga iyo maqalka;

Nicotinamide adenine dinucleotid ayaa sidoo kale ah bartilmaameedka tooska ah ee daawada isoniazid, oo loo isticmaalo daaweynta cudurka qaaxada, infekshinka keena qaaxada Mycobacterium. Hal tijaabo, jiilaalka la siiyay NAD hal toddobaad ayaa hagaajin lahaa isgaarsiinta nukliyeerka-mitochrondrial.

Intaa waxaa sii dheer, Nicotinamide adenine dinucleotide (NAD +) ayaa sidoo kale leh ka hortagga iyo daaweynta xannibaadda wadnaha, shaqada sanka iyo shaqada tijaabada dhakhsaha ah ee jimicsiga, nicotinamide waxay si weyn u wanaajin kartaa heerka garaaca wadnaha iyo xannibaadda loo yaqaan 'Atriove ntricular block' oo sababay verapamil.

Nicotinamide adenine dinucleotide(NAD +) Codsiga:

  1. Baadhitaannada cilladaha ee loo adeegsado agab cayriin ah, tijaabooyin cilmi-baaris cilmi ah.
  2. Cunto caafimaad, qurxinta, wax ku darista quudinta
  3. Wax soo saarka API

More Nicotinamide adenine dinucleotide(NAD +) cilmi baaris

Ensaemiyada sameysa iyo isticmaalka NAD + iyo NADH waxay muhiim u yihiin labadaba farmashiyooyinka iyo cilmi baarista daaweynta mustaqbalka ee cudurka. Coenzyme NAD + laf ahaantiisa hadda looma isticmaalo daaweynta cudur kasta. Si kastaba ha noqotee, waxaa loo bartay isticmaalkeeda suurtogalka ah ee daaweynta daweynta cudurada neurodegenerative sida cudurka AAlzheimer iyoParkinson.

Tixraaca:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + dheef-shiid kiimikaadka caafimaadka iyo cudurka" (PDF). Isbeddelada Biyo-wejiga. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Waxaa laga keydiyay asalka (PDF) taariikhdu markay ahayd 4 Juulaay 2009. Waxaa dib loo soo qaatay 23 Disember 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). “Aqoonsiga mitochondrial NAD + gaadiidleyda Saccharomyces cerevisiae”. J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Abriil 2003). "Nicotinamide adenine dinucleotide, maamule dheef-shiid kiimikaad qorista, cimri dheer iyo cudur". Curr. Furan. Unugga Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Xaaladda dib u soo celinta ee nicotinamide-adenine dinucleotide ee bilaashka ah ee cytoplasm iyo mitochondria ee beerka jiirka". Biyo-wejiga. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Maarso 1980). "Nicotinamide adenine dinucleotide biosynthesis iyo dheef-shiid kiimikaad oo loo yaqaan 'pyridine nucleotide metabolism-ka' nidaamyada microbial). Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Faransiiska SW. Aalkolada daba-dheeraada ee jirka waxay dhaawaceysaa beerka iyo xubnaha kale iyagoo yareynaya heerarka NAD⁺ ee looga baahan yahay waxqabadka deacetylase. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins iyo NAD + ee Horumarinta iyo Daaweynta Cudurrada Macdanta iyo Wadnaha. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.