Sulforaphane (4478-93-7)

March 8, 2020

Sulforaphane, oo sidoo kale loo yaqaan "dl-sulforaphane", waa dhisme dhir dabiici ah oo laga helo khudaarro badan oo iskutallaab ah sida ...

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Sulforaphane (4478-93-7) fiidiyow

Sulforaphane Smamnuucista

Product Name Sulforaphane
Magaca Kiimikada Sulforafan
DL-Sulforaphane
1-Isothiocyanato-4- (methylsulfinyl) butane
D, L-Sulforaphane
brand NAme N / A
Fasalka Daroogada Heerarka; Enzyme Firfircoonaanta iyo Xakameeyayaasha;
CAS Number 4478-93-7
InChikey SUVMJBTUFCVSAD-UHFFFAOYSA-N
Molecular Formula C6H11NOS2
Molecular Wsideed 177.3 g / mol
Monoisotopic Mass 177.028206 g / mol
dhibic kulayl  125-135 ° C
Fdib u soo celinta Psaliid N / A
Biological Life-Life N / A
Color jaalaha ah
SOlubility  DMSO: Laydh 40 mg / mL
Storage Temperature  -20 ° C
Application Budada Sulforaphane badanaa waxay ku dabakhaa nafaqada.

 

Waa maxay Sulfutanka?

Sulforaphane, oo sidoo kale loo yaqaan "dl-sulforaphane", waa dhisme dhir dabiici ah oo laga helo khudaarro badan oo iskutallaab ah sida broccoli, kaabajka, ubax, iyo kale.

Waa antioxidant-ka caadiga ah iyo sheyga ugu fiican ee firfircoon ee laga helo khudaarta. Sulforaphane kaliya ma leh dhaqdhaqaaq adag oo ka hortagga kansarka, laakiin sidoo kale wuxuu leeyahay awood adag oo ka hortagga sunta. Waxaa loo aqoonsan yahay inay tahay mid ka mid ah alaabada dabiiciga ah ee ka hortagga kansarka iyo saameynta quruxda.

Sulforaphane waxaa la soo saaraa marka enzyme myrosinase uu u beddelo glucoraphanin, glucosinolate, oo loo beddelo sulforaphane dhaawaca soo gaadha warshadda (sida cunidda), taas oo u oggolaaneysa labada xeryood inay isku daraan oo ay falceliyaan. Caleemaha yar yar ee broccoli iyo cadcad waxay si gaar ah hodan ugu yihiin glucoraphanin iyo sulforaphane.

Sulforaphane (SFN) waa mid loo yaqaan 'isothiocyanate', budada ka kooban budada baaruudka ah

 

Sulforaphane faa'iidooyinka

Faa'iidooyinka Caafimaadka ee Sulforaphane

Kaabista Sulforaphane ayaan FDA u oggolaan in loo adeegsado caafimaadka guud ahaanna aan lahayn cilmi baaris caafimaad oo adag. Xeerarku waxay dejinayaan heerarka wax soo saarka iyaga laakiin ma dammaanad qaadayaan inay amaan yihiin ama waxtar leeyihiin.

  • dhiirrigelinta ka-goynta
  • kobcinta maskaxda
  • ka caawinta jirka abuurista xeryo looga hortago kansarka
  • taageerida shaqada wadnaha ee caafimaadka qabta
  • kordhinta glutathione sida firfircoonaanta Nrf2
  • dhiirrigelinta miisaanka oo yaraada
  • gaabinta gabowga adoo ku dhaqaaqaya borotiinada kuleylka-shoogga
  • kor u qaadida shaqada beerka
  • yareynta caabuqa iyo xanuunka
  • Joojinta iyo dib u noqoshada timaha luminta.
  • Sulforaphane wuxuu yareyn karaa kolestarol LDL
  • Diabetes

Biqilka Broccoli wuxuu horumariyaa cabirro badan oo sonkorow. Nooca 2aad ee sonkorowga, cunista broccoli wuxuu ubaxayaa kordhinta awooda antioxidant-ka dhiigga iyo HDL kolesterol, waxaana hoos u dhacay culeyska 'oxidative stress', triglycerides, insulin, iska caabbinta insulin, iyo CRP.

  • Waxyeelada Maqaarka

Sulforaphane wuxuu bixin karaa kahortagida cudurka loo yaqaan UVA iyo bararka UVB, gubashada, iyo dhaawaca maqaarka.

  • Sulforaphane wuxuu yareeyaa astaamaha Autismka

Sulforaphane waxaa laga yaabaa inuu dhaqaajiyo hidda-wadeyaal gaar ah oo ka ilaaliya unugyada ka soo horjeedka walaaca 'oxidative stress', caabuqa, iyo dhaawaca DNA-ga, kuwaas oo dhammaantood la xiriira cudurka 'Autism spectrum disorder'.

  • Waxqabadka Antiviral

Sulforaphane wuxuu muujiyey waxqabad kahortaga fayraska markii unugyada cudurku toos u soo shaac baxaan

Cilladaha Sulforaphane iyo nabdoonaanta.

Sulforaphane waa amaan marka loo isticmaalo qadarka laga helo cuntooyinka. Laakiin ma jiro macluumaad ku filan oo la heli karo si loo ogaado haddii ay ammaan tahay in afka laga qaato daawo ahaan.

Sulforaphane wuxuu adeegsadaa iyo adeegsi

-Sulforaphane waxaa loo isticmaali karaa nadiifinta bakteeriyada waxyeelada leh ee sanbabada.

–Sulforaphane waxay leedahay shaqada ka hortagga caabuqa iyo ka bogsashada xanuunka arthritis.

-Sulforaphane wuxuu si dhakhso ah u bilaabi karaa habka bogsashada jirka, nidaamka sunta lagu nadiifiyo, dejinta shanta xubnood ee gudaha ah, isku dheelitirka, hagaajinta xubnaha dhaawacmay, sulforaphane wuxuu leeyahay saameynta kahortaga iyo daaweynta gout.

-Sulforaphane waxaa loo isticmaali karaa ka hortagga kansarka. Sulforaphane wuxuu si wax ku ool ah uga hortagi karaa boogta caloosha, atrophic gastritis oo isu beddelaya kansarka caloosha

–Sulforaphane waxaa lagu dabaqayaa goobta cuntada, sulforaphane waa nooc cunto fudud oo cagaaran si loo yareeyo culeyska;

–Sulforaphane waxaa lagu dabaqayaa goobta waxsoosaarka caafimaadka, celery wuxuu xasilin karaa niyadda wuxuuna baabi'in karaa xanaaq;

–Sulforaphane waxaa lagu dabaqayaa qeybta dawooyinka, si loo daweeyo laabotooyinka iyo buro waxay leedahay saameyn wanaagsan.

More Research

 

Sulforaphane budada gudaha Cancer Prostate cilmi

Sulforaphane (oo ah qaab loo yaqaan 'broccoli sprout extract') waxay ku faantaa xoogaa cadaymo caafimaad oo xoogaa ah doorka looga hortago kansarka qanjirka 'prostate' iyo istaraatiijiyooyinka maaraynta ee looga hortago soo noqoshada kansarka qanjirka 'prostate'.

Daraasado badan oo kiliinikada ah, ragga qaba kansarka qanjirka 'prostate prostate' oo qaatay 60 mg oo ah sulforaphane maalintii maalin kasta ayaa ka yaraatay dawada qanjirka 'prostate' (PSA, sumadee loo isticmaalay in lagu cabiro hormoonka qanjirka 'prostate') marka loo eego kuwa aan qaadan sulforaphane.

Taas ayaa la yiri, FDA ma aysan oggolaan sulforaphane ka hortagga dib u soo noqoshada kansarka qanjirka 'prostate'.

 

Tixraaca:

  • Cunfoga Sulforaphane ee Kansarka Chemoprevention: Doorka Sharciga Epigenetic Rehiblation iyo HDAC Inhibition Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis Antioxid Redox Signal. 2015 Jun 1; 22 (16): 1382– 1424. doi: 10.1089 / ars.2014.6097 Sulforaphane wuxuu habeeya apoptosis- iyo tilmaamaha la xiriira kobcinta iyo isku-darka leh cisplatin si loo xakameeyo kansarka ugxaanta aadanaha Shi-Feng Kan, Jian Wang, Guan-Xing Sun Int J Mol Med. 2018 Nov; 42 (5): 2447–2458. La daabacay khadka internetka 2018 Sep 6. doi: 10.3892 / ijmm.2018.3860
  • Bioavailability of Glucoraphanin iyo Sulforaphane oo ka socda High ‐ Glucoraphanin Broccoli Tharsini Sivapalan, Antonietta Melchini, Shikha Saha, Paul W. Needs, Maria H. Traka, Henri Tapp, Jack R. Dainty, Richard F. Mithen Mol Nutr Food Res. 2018 Sep; 62 (18): 1700911. Waxa la daabacay khadka tooska ah ee 2018 Mar 8. doi: 10.1002 / mnfr.201700911
  • Ka hortagga cudurka Kansarka ee afka laga qaato ee Kansarka afka laga helo ee Sulforaphane Julie E. Bauman, Yan Zang, Malabika Sen, Changyou Li, Lin Wang, Patricia A. Egner, Jed W. Fahey, Daniel P. Normolle, Jennifer R. Grandis, Thomas W. Kensler , Daniel E. Johnson Cancer Prev Res (Phila) qoraalka qoraaga; waxaa laga heli karaa PMC 2017 Jul 1. Waxaa lagu daabacay foomka kama dambeysta ah ee la edbiyey sida: Cancer Prev Res (Phila). 2016 Jul; 9 (7): 547-557. Waxaa lagu daabacay khadka internetka 2016 Jun 23. doi: 10.1158 / 1940-6207.CAPR-15-0290
  • Daraasad wejiga II ah ee saliidaha 'brofooli-hodanka ah ee broccoli wuxuu soosaaraa ragga ku dhaca kansarka soo noqnoqda ee Joshi J. Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N. Graff, Tomasz M. Beer, Christopher W. Ryan, Dennis R. Koop, Angela Gibbs, Lina Gao, Jason F. Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori Invest Drugs New. Qoraaga qoraaga; waxaa laga heli karaa PMC 2016 Apr 1. Waxaa lagu daabacay foomka kama dambeysta ah ee la edbiyey sida: Invest Invest Drugs New. 2015 Apr; 33 (2): 480–489. Waxaa lagu daabacay khadka internetka 2014 Nov 29. doi: 10.1007 / s10637-014-0189-z