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Raw Lorcaserin HCL budada (846589-98-8)

Rooga Lorcaserin hydrochloride waa serotonin 2C (5-HT2C) agonist resonator iyo dawo afka laga qaato oo dhiirrigeliya ....


Status: Wax soosaarka Mass
Unugga: 25kg / Drum
Capacity: 1380kg / bishii

Description

Video Raw Lorcaserin HCL (846589-98-8) video

Raw Lorcaserin HCL budada (846589-98-8) Qeexitaannada

Product Name Raw Lorcaserin Hydrochloride budada
Magaca Kiimikada Raw Lorcaserin HCL budada, Lorcaserin
brand NAme BELVIQ
Fasalka Daroogada 5-HT2C daaweeye-celiyaha
CAS Number 846589-98-8
InChikey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Molecular Formula C11H15Cl2N
Molecular Wsideed 232.15
Monoisotopic Mass 231.058154899
barafku Psaliid Macluumaad lama heli karo
Fdib u soo celinta Psaliid Macluumaad lama heli karo
Biological Life-Life Nolosha nuska ah ee lorcaserin waa qiyaastii saacadaha 11. Dufanka lorcaserin ayaa laga jarayaa inta badan kaadida (92%) iyo saxarada (2.2%)
Color budo White
milmi Biyaha Solubility: 0.0709 mg / mL
kaydinta Temperature -20 ° C.
Application Serotonin 2C (HT2C) Agonist oo loogu talagalay miisaan lumis ah. Waxay yareysaa isticmaalka cuntada iyo kor u qaadida saturada

Raw Lorcaserin HCl budada (846589-98-8) Sharaxaad

Root Lorcaserin hydrochloride waa hydrochloride oo lagu helo falcelinta budada lorcaserin oo leh hal u dhigma acid hydrochloric. Waxaa loo isticmaalaa daroogada ka hortagga uurka. Lorcaserin hydrochloride waa 5HT2c loo yaqaan agonist oo loogu talagalay isticmaalka dadka qaangaarka leh BMI ≥30, ama kuwa leh BMI ≥27 iyo ugu yaraan hal miisaan la xiriira sida hypertension, nooca sonkorowga 2 ama dyslipidemia.Lorcaserin Hydrochloride waxay u shaqaysaa xakamaynta cunto yari iyo wuxuu dareemayaa dareen ah, oo waxaa loo maleynayaa inuu iska ilaaliyo roobabkii wadnaha ee wadnaha ee la xidhiidha dhaqdhaqaaqa 5-HT2B reseptors, aagga maskaxda loo yaqaano inuu kaalin weyn ka ciyaaro nidaaminta gaajada iyo cunto qaadashada. Iyadoo la adeegsanaayo qaboojiyayaashan, budada Lorcaserin hydrochloride waxay yarayn kartaa isticmaalka cuntada iyada oo la yareeyo cunto xumida iyo in qofku dareemo inuu dareemo xitaa marka uu cuno cunto ka yar intii caadiga ahayd. ayaa maanta loo ansixiyay FDA oo ah go'aan ka soo baxay 2 sannadkii.

Lorcaserin hydrochloride waxay si gaar ah u tilmaameysaa in ay tahay nafaqo yar oo kalooriye ah iyo firfircoonida jirka ee miisaanka culus ee dadka waaweyn ee qalliinka ah (BMI ee 30 kg / m2 ama ka weyn) iyo dadka waaweyn ee culeyska (BMI of 27 kg / m2 ama ka weyn) iyadoo ugu yaraan hal xaaladood oo miisaanka la xidhiidha.

Kiniin Lorcaserin hydrochloride waxaa loo isticmaalaa cuntada iyo jimicsiga si loo daaweeyo cayilka. Mararka qaarkood waxaa loo isticmaalaa in lagu daaweeyo cayilka oo laga yaabo inuu la xiriiro sonkorowga, kolestaroolka sare, ama dhiig kar.

Lorcaserin hydrochloride ma daaweyn doonto xaalad caafimaad oo hoose (sida cudur wadne, sonkorow, cadaadis dhiig oo sarreeya). Hayso qaadashada dawooyin kale oo dhakhtarkaagu kuu qoray daaweynta xaaladahaas.

Lorcaserin HCl budada (846589-98-8) Mashruuca Hawlaha

Inkastoo nidaamka saxda ah aan la ogeyn, waxaa la rumeysan yahay in uu ku lug yeesho dhaqdhaqaaqa xeeladeysan ee 5-HT2C ee dhexdhexaadiyeyaasha anorexigenic pro-opiomelanocortin neurons oo ku jira nucleuska wadnaha ee hypothalamus. Tani waxay sababtaa hoos u dhaca helitaanka raashinka iyo fadeexada iyadoo la dhiirigelinayo sii deynta alfa-melanocortin kicinta hormoonka, taas oo wax ka qabta reseptors melanocortin-4.

Kiniinada Lorcaserin hydrochloride waxay u shaqaysaa xakamaynta cuntada, gaar ahaan iyada oo la hawlgelinayo xayawaanka maskaxda ee serotonin, neurotransmitter oo kiciya dareenka sinnaanta iyo qanacsanaanta. Cunto qaadashada waxaa gacanta ku haya xarun farsamo, oo ku taalla nucleus nucleus oo ah hypothalamus iyo xarunta gaajada ee joogtada ah ee lateral hypothalamus. Waxyaabo kala duwan oo ka yimaada xarumo sare iyo mareenada caloosha ayaa isku dhejiya nucleus, oo laba nooc oo ah qanjirro xakameynaya cunto qaadashada. Ugu horreyntii, kooxda kicinta cuntooyinka qaadata ee soo saarta borotiinka agooti-la-xiriira iyo neuropeptide Y; iyo marka labaad, koox cunto-qaadasho ah oo la socota oo ay ku jirto cocaine iyo amphetamine oo ah habka loo yaqaan "transcript" (CART) iyo pro-opiomelanocortin (POMC) neurons. POMC waxaa ku jira receptors 5-HT 2C, oo marka firfircoon la sii daayo hormoonada alpha-melanocyte-stimulating hormone (alpha-MSH) .Dhibaatooyinka xayiraadaha iyo kicinta ayaa dhiirrigelin kara nukleerka nukleuska ee hypothalamus. Qalabka Paraventricular waxaa ku jira xayawaannada melanocyte 4 (MC4R) oo joojiya rabitaanka cuntada ee daaweynta lorcaserin hydrochloride sida xannibaad 5-HT 2C ah oo ku salaysan xanuunka POMC, taasoo keenta in la sii daayo alfa MSH. Alpha MSH dheeraad ah waxay wax ka qabataa MC4R ee nukleerka nukleus ee hypothalamus, taasoo keentay hoos u dhaca cuntada. Daawooyinka supraterapeutic, lorcaserin hydrochlorider waxay sidoo kale wax ka qabtaa 5-HT 2B iyo 5-HT 2A reseptors.

Faa'iidooyinka of Lorcaserin Hcl budada (846589-98-8)

  • Lorcaserin HCL budada waa 5-HT2C gardaroole loo yaqaan 'agonist' oo loo maleeynayo in la yareeyo cuntooyinka laga qaato nidaamka POMC dhexe. Faa'iidooyinka budada Lorcaserin HCL:
  • Lorcaserin HCL budada waxaa loo isticmaalaa cunto iyo jimicsi si loo daaweeyo cayilka.
  • Lorcaserin HCL ayaa mararka qaarkood loo isticmaalaa in lagu daaweeyo cayilka oo la xidhiidha sonkorowga, kolestaroolka sare, ama dhiig kar.
  • Lorcaserin HCL budo ma daaweyn doonto xaalad caafimaad oo hoose (sida cudur wadne, sonkorow, cadaadis dhiig oo sarreeya).

Lagu taliyay budada Lorcaserin Hcl (846589-98-8)

Budada Lorcaserin HCL waxay ku timaadaa qaab kiniini ah waxaana la qaataa 1-2 jeer maalintii, iyadoo leh ama aan lahayn cunto. Lorcaserin waa in la isticmaalo iyada oo la raacayo cunto yareeyaal yar iyo qorshe jimicsi.

Qiyaasta lagu taliyey ee budada lorcaserin hcl waa 10 mg oo afka laga qaato laba jeer maalintii. Lorcaserin waxaa laga yaabaa in la qaato iyada oo aan loo eegin cuntada. Lorcaserin hcl waa in la joojiyaa bukaanada kuwaas oo ku fashilmay in ay gaaraan ugu yaraan 5% miisaanka lumitaanka todobaadkii 12 maadaama bukaanadani aysan u dhicin inay lumiyaan miisaan laxiriira leh daaweyn socota.

Dhibaatooyinka ay keento of Lorcaserin Hcl budada (846589-98-8)

Lorcaserin HCC ayaa loo isticmaalaa daaweynta miisaanka miisaanka dheer ee dadka qaangaarka ah ee leh qiyaasta jirka ee jirka (BMI) ee 30 ama ka weyn (obese) oo lagu daro cunto yar oo kalooriye ah iyo jimicsi. Waxaa sidoo kale loo oggol yahay isticmaalka dadka waaweyn ee leh BMI of 27 ama ka weyn (miisaanka culus) oo leh ugu yaraan hal xaaladood oo miisaanka la xidhiidha sida dhiig karka (hypertension), ama kolesterool (dyslipidemia). Si kastaba ha noqotee, waxaa laga yaabaa inay sidoo kale leedahay saameyno kale. Sida hoos ku qoran:

TIsbedelada ugu caansan ee daaweynta:

  • -Headache,
  • -Dhibaato,
  • -Fatigue,
  • -Hadaba,
  • -Day afka,
  • -Saweyn, iyo
  • -Hypoglycemia (sonkorta dhiigga yar).

Waxyeellooyinka kale ee aan caadiga ahayn ee halista ah ee la xiriira lorcaserin waxaa ka mid ah:

  • -Ku xir dhibaatooyinka valfka,
  • -Kooxda dareenka ama xusuusta,
  • - Dhibaatooyinka maskaxda,
  • -Dabitaanka ama fikradaha isdilka,
  • -Dhibaatooyin adag,
  • -Ka fogow garaaca wadnaha,
  • -Kulalka dhiiga tira dhiiga, iyo
  • -In la kordhiyo hormoonka, prolactin.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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Tixraacyada iyo xaashiyadaha alaabada

FDA oo la ansixiyay Lorcaserin HCL loogu talagalay Daaweynta Caanaha

tixraacyada

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., et al .: Ammaanka Wadnaha ee Lorcaserin ee Dadka Bukaanka ah ama Bukaanka, Wargeyska New England Journal of Medicine, 2018
  2. Maamulka Cuntada iyo Maandooriyeyaasha, Daawooyinka Targetka Xakamaynta Culayska Muddada-dheer, Online, La daabacay 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose AR, Xarunta Qaranka ee Macluumaadka Biotechnology, Maqaalada PMC, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

Shangke Kiimikadu waa shirkad tayo sare leh oo ku takhasusay dhexdhexaadinta firfircoon ee daawada (APIs). Si loo xakameeyo tayada inta lagu jiro wax soo saarka, tiro badan oo xirfadlayaal khibrad leh, qalab wax soosaaraya iyo shaybaarrada ayaa ugu muhiimsan.

Nala soo xiriir