Anandamide (AEA) (94421-68-8)

March 15, 2020

Anandamide, oo sidoo kale loo yaqaan N-arachidonoylethanolamine (AEA), waa neurotransmitter dufan leh oo ka soo jeeda derived ..

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Anandamide (AEA) (94421-68-8) fiidiyaha

Anandamide (AEA) (94421-68-8) Smamnuucista

Product Name Anandamide (AEA)
Magaca Kiimikada Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChikey LGEQQWMQCRIYKG-DOFZRALJSA-N
dhoolla caddayntaada CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Formula kelli C22H37NO2
Miisaanka kelli 347.53
Monoisotopic Mass 347.282429 g / mol
Dhibicda Biyaha N / A
Boiling Point 522.3 ± 50.0 ° C (Saadaaliyay)
mugga 0.92 g / mL markay tahay 25 ° C (laambad)
Color iftiin huruud ah
Skulayl daran -20 ° C
milmi ethanol: L
Codsiga Waxaa loo isticmaalaa xusuusta, dhiirigelinta, geedi socodka garashada, xakameynta dhaqdhaqaaqa, xakameynta xanuunka, kicinta cuntada iyo bacrinta.

 

Waa maxay Anandamide (AEA)?

Anandamide, oo sidoo kale loo yaqaan N-arachidonoylethanolamine (AEA), waa neurotransmitter dufan leh oo laga soo qaatay dheef-shiid kiimikaad la'aan ah eicosatetraenoic acid (arachidonic acid. Wuxuu leeyahay qaab-dhismeed aad ugu eg kan tetrahydrocannabinol, qeybta firfircoon ee xashiishka. ugu horreyntii waxaa hoos u dhigay enzyme fatty acid amide hydrolase (FAAH) enzyme, kaas oo u beddelaya anandamide ethanolamine iyo arachidonic acid, Ugu dambeyntiina, Anandamide waxaa lagu soo saaray neuron iyada oo falcelinta uumiga ay ka dhex dhacdo arachidonic acid iyo ethanolamine iyadoo la raacayo qawaaniinta kalsiyum ion iyo cyclic monophosphate adenosidase Waa horudhac koox walxaha jir ahaaneed firfircoon (Prostamides) oo door ka ciyaara nashaadaadyo badan oo jireed, oo ay ka mid yihiin rabitaanka cuntada, xusuusta, xanuunka, murugada, iyo taranka.

Anandamide wuxuu ku jiraa nooleyaal badan, sida roe urchin roe, maskaxda doofaarka iyo beerka jiirka, iwm, laakiin tiradooda way yartahay. Sidoo kale, cilmi baarayaashu waxay kaloo ka heleen Anandamide iyo laba walxo (N-oleoylethanolamine iyo N-Linoleylethanolamine) oo ku jira shukulaatada madow. Anandamide xitaa wuxuu kujiraa qaar ka mid ah miraha la warshadeeyay, (rootiga cad), Khamriga (gaar ahaan, isticmaalka daba dheeraada ama cabitaanka badan), sonkor la sifeeyay, dufanka trans, Cuntooyinka lagu shiilay saliida cuntada iyo cuntooyinka aan dabiiciga aheyn ee ka kooban sunta cayayaanka iwm.

Iyada oo qayb ka ah nidaamka endocannabinoid (ECS), Anandamide waxaa loo kala saaray hab-maamule of homeostasis oo ay weheliso fasal kale oo cannabis-sida kiimikada ah 2-AG iyo qabtayaasha cannabinoid-ka jirka oo dhan. Nidaamkani wuxuu ku jiraa dhammaan qaabdhismeedka Anandamide waxay door ka ciyaaraysaa hagaajinta dhaqanka quudinta iyo dhiirrigelinta neerfaha iyo raaxeysiga, ku haynta jirkeenna iyo maskaxdeenna isu dheelitirnaan. Daraasaduhu waxay ogaadeen in shucuurtayada, farxadda, cabsida, walwalka, iyo awooda aan u adkeysan karno walbahaarka dhamaantood lagu habeeyo nidaamka endocannabinoid, iyo cuduro kala duwan oo iskudhexyaaca ilaa jahwareerka waxaa weheliya heerar anandamide aan caadi ahayn.

Anandamide, oo la mid ah THC, waa agonist qayb ka mid ah CB1R. Waxay sababi kartaa kor uqaadis suurtagal ah iyadoo “buuxa” firfircoonaanta nidaamka maskaxda. Waxaa xusid mudan in saameyntan oo dhan ee Anandamide ay umuuqato in lagu sii wanaajiyay iyadoo si farsameysan looga hortagayo nabaad-guurka dheef-shiid kiimikaadka. Soo helitaanka Anandamide wuxuu u horseedi karaa horumarinta qoys gebi ahaanba cusub oo daroogada lagu daweeyo ah.

 

Faa'iidooyinka Anandamide (AEA)

Anandamide, oo sidoo kale loo yaqaan "bliss molecule", waa dhiirrigeliye niyadda, neurotransmitter iyo endocannabinoid, oo leh caafimaad iyo faa'iidooyin maskaxeed oo badan:

Anandamide waxay yareysaa sameynta deg degga ah ee unugyada kansarka. Sannadkii 1998, koox ka tirsan saynisyahano Talyaani ah ayaa ogaadey in anandamide ay horumarin karto neurogenesis ayna sameyso unugyo dareeme oo cusub, si wax ku ool ah u gaabin karaan sameynta / kordhinta qiimaha unugyada kansarka naasaha.

Awoodda Anandamide ee dhiirrigelinta neurogenesis (sameynta neerfayaasha cusub) ayaa door ka ciyaara xakameynta dhaqanka quudinta iyo abuurista dhiirrigelinta iyo raaxeysiga jiirka. Tani waxay kaa caawinaysaa yareynta astaamaha niyad-jabka iyo walwalka. Daraasad la sameeyay 2015 ee bini'aadamka iyo jiirka ayaa lagu ogaaday in heerarka sare ee anandamide ay kor u qaadi karto hagaajinta niyadda iyo yareynta cabsida.

Intaa waxaa dheer, awoodda anandamide ee ku xirnaanta CB1 iyo CB2 soo dhaweeyeyaasha ayaa sidoo kale si qoto dheer u saameyn doonta farsamooyin badan oo jir ahaaneed, oo muujinaya faa'iidooyin wanaagsan marka la eego xusuusta, dhiirigelinta, hababka garashada, xakameynta dhaqdhaqaaqa, xakameynta xanuunka, kicinta rabitaanka cuntada iyo bacriminta.

 

Sida loo kordhiyo anandamide(AEA) heerarka jirka aadanaha?

Sababta oo ah anandamide waxay leedahay door ah neurotransmitter, wakiilka vasodilator iyo dheef-shiidka dhiiga aadanaha, iyo faa'iidooyinka caafimaad iyo maskaxeed ee la muujiyey, waxaad u baahan kartaa inaad kordhiso heerka anandamide ee jirkaaga. Waa kuwan qaar ka mid ah qaabab si ku meel gaar ah loogu kordhiyo heerarka anandamide ee jirka bini aadamka:

- Jimicsigaing

Daraasadu waxay ogaatay in kadib 30 daqiiqo oo kaliya markii ay socdeen, ay kordhayaan maadada anandamide (AEA) ee dadka iyo eeyahaba. Sidaa darteed haddii aad rabto inaad hesho faa'iidada ugu badan, samee jimicsi jimicsi badanaa.

- Cunista shukulaatada madow

Shukulaatada mugdiga ah waxay leedahay saami sare oo ah tan loo yaqaan 'theromromine' ee shukulaatada caafimaadka leh, iyo tan loo yaqaan 'theromromine' waxay gacan ka geysaneysaa kordhinta wax soo saarka anandamide ee maskaxda isla markaana si ku meel gaar ah u gaabiyo.

- Cunista dhalo madow

Dharka madow (fungus madow) dabiici ahaan waxaa ku jira anandamide. In kasta oo fungus uusan dhab ahaan u adeegsan karin anandamide-ka, cilmi-baarayaashu waxay rumeysan yihiin in loo istcimaalo in lagu soo jiito xayawaan si ay u cunaan ugana soo saaraan kudarradooda

- Diirad saarid

Cilmi baaris ayaa muujisay in marka qofku ku sugan yahay gobol (oo loo yaqaan "qulqulka" ama "gobol,") feejignaan sare, waxqabad, iyo feejignaan, ma aha oo kaliya inaad wax soo saar badan noqon doontid ama shaqo abuur fiican ka abuuri karto maskaxdaada Waxay kaloo sii deyneysaa a tiro badan oo kiimikooyin ah, sida serotonin, dopamine, endorphin iyo anandamide.

Intaa waxaa dheer, shaaha, coriander iyo celery waxay kaloo gacan ka geysan karaan kordhinta wax soo saarka anandamide.

 

Tixraaca:

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  • El-Talatini MR, Taylor AH, Konje JC (Abriil 2010). "Xiriirka ka dhexeeya heerarka plasma ee endocannabinoid, anandamide, steroids galmada, iyo gonadotrophins inta lagu jiro wareegga caadada". Bacriminta Jeermis 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
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