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Anandamide (AEA) (94421-68-8)

Anandamide, sidoo kale loo yaqaan N-arachidonoylethanolamine (AEA), waa aashitada neerfaha ee dufanka laga helo …… ..


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

Anandamide (AEA) (94421-68-8) Smamnuucista

Product Name Anandamide (AEA)
Magaca Kiimikada Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChikey LGEQQWMQCRIYKG-DOFZRALJSA-N
dhoolla caddayntaada CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Formula kelli C22H37NO2
Miisaanka kelli 347.53
Monoisotopic Mass 347.282429 g / mol
Dhibicda Biyaha N / A
Boiling Point 522.3 ± 50.0 ° C (Saadaaliyay)
mugga 0.92 g / mL markay tahay 25 ° C (laambad)
Color iftiin huruud ah
Skulayl daran -20 ° C
milmi ethanol: soluble
Codsiga Waxaa loo isticmaalaa xusuusta, dhiirigelinta, geedi socodka garashada, xakameynta dhaqdhaqaaqa, xakameynta xanuunka, kicinta cuntada iyo bacrinta.

Waa maxay Anandamide (AEA)?

Anandamide, oo sidoo kale loo yaqaanno N-arachidonoylethanolamine (AEA), waa aashitada neerfaha ee loo yaqaan 'acids acids neurotransmitter fat' taasoo laga soo saarey dheef-shiid kiimikaad-eicosatetraenoic acid (arachidonic acid.) Waxay leedahay qaab aad u lamid ah tetrahydrocannabinol, oo ah xubin firfircoon ee xashiishadda. ugu horrayn, Anandamide waxaa isku-dhafan neuron-ka kadib falcelinta uumiga waxay udhaxeeysaa arachidonic acid iyo ethanolamine iyadoo la raacayo qaanuunka kaalshiyamka ah ee loo yaqaan 'calcium ion iyo cyclic monophoidhate'. Waa hordhac koox ka kooban maandooriyayaal firfircoon (Prostamides) oo door ka ciyaara hawlo badan oo jireed, oo ay ka mid yihiin rabitaanka cuntada, xusuusta, xanuunka, niyad jabka, iyo bacriminta .. Intaa waxaa sii dheer, Anandamide sidoo kale waxay xannibisaa bini'aadamka fiditaanka unugyada kansarka naasaha.

Anandamide waxay ku jirtaa noolal badan, sida bad urchin roe, maskaxda doofaarka iyo jiirka, iwm, laakiin tiradiisu waa yar tahay. Sidoo kale, baarayaasha waxay sidoo kale ka heleen Anandamide iyo laba maado (N-oleoylethanolamine iyo N-Linoleylethanolamine) oo shukulaato mugdi ah. Anandamide xitaa waxaa laga helaa qaar ka mid ah hadhuudhka la warshadeeyay, (rootiga cad), Aalkolada (qaasatan, isticmaalka daba dheeraada ama cabitaanka xad dhaafka ah), sokorta dib loo macaan yahay, dufanka trans, Cunnooyinka lagu shiilay saliida cuntada iyo cuntada aan dabiiciga aheyn ee kujira sunta cayayaanka iwm.

Iyada oo qayb ka ah nidaamka endocannabinoid (ECS), Anandamide waxaa loo kala saaray hab-maamule of homeostasis oo ay weheliso fasal kale oo cannabis-sida kiimikada ah 2-AG iyo qabtayaasha cannabinoid-ka jirka oo dhan. Nidaamkani wuxuu ku jiraa dhammaan qaabdhismeedka Anandamide waxay door ka ciyaaraysaa hagaajinta dhaqanka quudinta iyo dhiirrigelinta neerfaha iyo raaxeysiga, ku haynta jirkeenna iyo maskaxdeenna isu dheelitirnaan. Daraasaduhu waxay ogaadeen in shucuurtayada, farxadda, cabsida, walwalka, iyo awooda aan u adkeysan karno walbahaarka dhamaantood lagu habeeyo nidaamka endocannabinoid, iyo cuduro kala duwan oo iskudhexyaaca ilaa jahwareerka waxaa weheliya heerar anandamide aan caadi ahayn.

Anandamide, oo la mid ah THC, waa qayb ka mid ah dhexdhexaadiyaha CB1R. Waxay u horseedi kartaa kor u qaadista suurtogalka ah "firfircoon" buuxa ee nidaamka maskaxda. Waxaa xusid mudan in dhammaan saameyntan Anandamide ay u muuqato inay sii xoogeysaneyso iyada oo loo adeegsanayo daawooyinka ay ka hortageyso nabaad-guurkeeda. Soo helista Anandamide waxay u horseedi kartaa horumarinta qoyska gebi ahaanba cusub daawooyinka daaweynta.

Faa'iidooyinka Anandamide (AEA)

Anandamide, oo sidoo kale loo yaqaan "molecule blissle", waa kobciyaha niyadda, neurotransmitter iyo endocannabinoid, oo leh faa'iidooyin badan oo caafimaad iyo maskaxeed:

Anandamide waxay yareysaa sameynta deg degga ah ee unugyada kansarka. Sannadkii 1998, koox ka tirsan saynisyahano Talyaani ah ayaa ogaadey in anandamide ay horumarin karto neurogenesis ayna sameyso unugyo dareeme oo cusub, si wax ku ool ah u gaabin karaan sameynta / kordhinta qiimaha unugyada kansarka naasaha.

Awoodda Anandamide ee lagu horumarinayo neurogenesis (sameynta neerfayaasha cusub) waxay door ka ciyaaraysaa xakameynta dabeecadda quudinta iyo abuurista dhiirigelinta iyo farxadda jiirka. Tani waxay ka caawineysaa yareynta calaamadaha murugada iyo walaaca. Daraasad sanadkii 2015 ee aadanaha iyo jiirarka ayaa lagu ogaaday in heerarka sare ee anandamide ay kor u qaadi karto hagaajinta niyadda iyo yareynta cabsida

Intaa waxaa sii dheer, awoodda anandamide ee ay kuxiran karto CB1 iyo CB2 receptors waxay sidoo kale saameyn weyn ku yeelan doontaa habab badan oo jimicsi ah, oo muujineysa faa'iidooyin wanaagsan xagga xusuusta, dhiirrigelinta, hannaanka garashada, xakameynta dhaqdhaqaaqa, xakameynta xanuunka, kicinta rabitaanka cuntada iyo bacrinta.

Sida loo kordhiyo anandamide(AEA) heerarka jirka aadanaha?

Sababta oo ah anandamide waxay leedahay door ah neurotransmitter, wakiilka vasodilator iyo dheef-shiidka dhiiga aadanaha, iyo faa'iidooyinka caafimaad iyo maskaxeed ee la muujiyey, waxaad u baahan kartaa inaad kordhiso heerka anandamide ee jirkaaga. Waa kuwan qaar ka mid ah qaabab si ku meel gaar ah loogu kordhiyo heerarka anandamide ee jirka bini aadamka:

- Jimicsigaing

Daraasadu waxay ogaatay in kaliya kadib 30 daqiiqo oo orod ah, maadada anandamide (AEA) ee dadka iyo eeyahaba ay kordheen. Markaa hadaad rabto inaad ka hesho faa iidada ugu badan, samee jimicsi jimicsi aerobic badanaa.

- Cunista shukulaatada madow

Shukulaatada mugdiga ah waxay leedahay saami sare oo ah tan loo yaqaan 'theromromine' ee shukulaatada caafimaadka leh, iyo tan loo yaqaan 'theromromine' waxay gacan ka geysaneysaa kordhinta wax soo saarka anandamide ee maskaxda isla markaana si ku meel gaar ah u gaabiyo.

- Cunista xashiish madow

Dharka madow (fungus madow) dabiici ahaan waxaa ku jira anandamide. In kasta oo fungus uusan dhab ahaan u adeegsan karin anandamide-ka, cilmi-baarayaashu waxay rumeysan yihiin in loo istcimaalo in lagu soo jiito xayawaan si ay u cunaan ugana soo saaraan kudarradooda

- Helitaanka diiradda

Baadhitaan la sameeyay ayaa muujinaya in qofku marka uu ku sugan yahay gobolka (oo loo yaqaan "qulqulka" ama "gobol,") ee feejignaan sare, wax qabad, iyo feejignaan, ma aha oo kaliya inaad noqotid mid wax soo saar leh ama aad shaqooyin fiican uga abuuri doonto maskaxdaada waxay sidoo kale sii deyneysaa a tiro kiimikooyin ah, sida serotonin, dopamine, endorphin iyo anandamide.

Intaa waxaa dheer, shaaha, coriander iyo celery waxay kaloo gacan ka geysan karaan kordhinta wax soo saarka anandamide.

Tixraaca:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Meey 2001). "Anandamide iyo cunnada: Isku darista arachidonate ee cuntada iyo docosahexaenoate waxay horseedaysaa inay kordho heerarka maskaxda ee isku-dhafka ah ee N-acylethanolamines ee piglets". Talaabooyinka Akadeemiyada Qaranka ee Sayniska. 98 (11): 6402– Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Abriil 2010). "Xiriirka ka dhexeeya heerarka plasma ee endocannabinoid, anandamide, steroids galmada, iyo gonadotrophins inta lagu jiro wareegga caadada". Feeraha. Steril. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M.; Okorokov, Andrei L .; Hill, Matthew N.; Bras, Jose T.; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J.; van Drimmelen, Marie; Morena, Maria (Maarso 2019). "Microdeletion ee qoraal been abuur ah ayaa lagu cadeeyay bukaanka qaba culeysyada anandamide ee sareeya iyo nasiinada xanuunka". Joornaalka Ingiriiska ee suuxinta. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Noofembar 2007). "Endocannabinoid hedonic hotspot oo loogu talagalay raaxada dareenka: anandamide-ka Nucleus-ka wuxuu kiciyaa qolofka wuxuu 'wanaajiyaa' abaalmarin macaan '. Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). “Wadada aan xirneyn ee loo yaqaan cannabinoid ligands, anandamides”. Pertwee RG (ed.). Qaadashadayaasha Cannabinoid. Boston: Saxaafadda Aqoonta. pp 233 – ISBN 978-0-12-551460-6.
  • Mallet PE, Beninger RJ (1996). "Sumogenous cannabinoid receptor agonist anandamide wuxuu wax u dhimayaa xusuusta ee jiirka". Farmashiyaha Dabeecadda. 7 (3): 276– doi: 10.1097 / 00008877-199605000-00008.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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