Dihydromyricetin (DHM) (27200-12-0)

March 9, 2020

Dihydromyricetin (ama DHM) waa soo saarid laga soo qaatay Geedka Raisin ee Jabbaan ee loo isticmaali jiray qarniyo badan sidii aalkolada ka hortagga …….


Status: Wax soosaarka Mass
Isuduwis iyo Haboonaanta La Isticmaali karo
Capacity: 1277kg / bishii

Dihydromyricetin (DHM) (27200-12-0) fiidiyow

Dihydromyricetin Smamnuucista

Product Name Dihydromyricetin (DHM)
Magaca Kiimikada Ampelopsin
Ampeloptin
(+) - Dihydromyricetin
brand Name N / A
Fasalka Daroogada phytoche kemikal ah
CAS Number 27200-12-0
InChikey KJXSIXMJHKAJOD-LSDHHAIUSA-N
Molecular Formula C15H12O8
Molecular Wsideed 320.25 g / mol
Monoisotopic Mass 320.053217 g / mol
dhibic kulayl 780.7 ± 60.0 ° C (Saadaaliyay)
Fdib u soo celinta Psaliid N / A
Biological Life-Life N / A
Color caddaan ah si beige ah
SOlubility DMSO: ≥5mg / mL (diirimaad)
Storage Temperature <+ 8 ° C
Application 1. Waxaa lagu dabaqay warshadaha quudinta, budada loo yaqaan 'dihydromyricetin' oo loo isticmaalo agab ceyriin ah;
2. Lagu dabaqay waxsoosaarka caafimaadka, budada loo yaqaan 'dihydromyricetin budada' oo loo isticmaalo sidii ashyaa'da ceyriinka si kor loogu qaado difaaca jirka
3. Waxaa lagu dabaqay maandooriyaha dawada, budada dheecaannada dihydromyricetin ee loo isticmaalo kaabsoosha ama kaniiniyada lagu daweeyo caabuqyada neef-mareenka iyo ilaalinta beerka.

Taariikhda Dihydromyricetin

Dihydromyricetin (ama DHM) waa soo saarid laga soo qaatay Geedka Raisin ee Jabbaan oo loo isticmaali jiray qarniyaal sidii geedo ka hortagga alkolada ah iyo dawada dhaqameed ee Kuuriyada iyo Shiinaha. Daraasadihii ugu dambeeyay waxay soo jeedinayaan in DHM ay hoos u dhigi karto heerka aalkolada dhiiggaaga ayna ka ilaalin karto beerkaaga waxyeelo iyo cudur.

DHM waa flavonoid sida caadiga ah laga soo saaro Vine Shaaha laakiin sidoo kale waxaa laga soo saari karaa jilif geedka Holvenia Dulcis. Iyo tan ugu muhiimsan, Dihydromyricetin waxay leedahay taariikh dheer oo loo qaatay si gaar ah ujeeddooyinka lagu daweeyo madax xanuun iyo hangovers.

Waa maxay Dihydromyricetin?

Dihydromyricetin, oo sidoo kale loo yaqaan Ampelopsin, waa flavanonol, nooc ah flavonoid. Waxaa laga helaa noocyada Ampelopsis japonica, megalophylla, iyo grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; qaar ka mid ah noocyada Pinus; iyo qaar ka mid ah noocyada Cedrus, iyo sidoo kale Salix sachalinensis.

Budada soosaarta Dihydromyricetin, waxyaabaha ugu muhiimsan ee firfircoon waa flavonoids. Iyada oo laga duulayo howlaha lagu baadi goobayo xagjiriinta xorta ah, antioxidants, antithrombotic, Tumor, anti-bararka iyo dhibaatooyinka kale ee ku dhaca; Dihydromyricetin waa xarun gaar ah oo flavonoid ah. Marka lagu daro astaamaha guud ee flavonoids, waxay sidoo kale leedahay awood ay ku yareyso sumowga aalkolada, ka hortagga beerka aalkolada leh, beerka dufanka leh, iyo xanniba unugyada beerka. Ka sii darista iyo yareynta dhacdooyinka kansarka beerka. Waa badeecad wanaagsan oo lagu ilaaliyo beerka iyo is-dhaafsiga.

Dihydromyricetin faa'iidooyinka

FAA'IIDADA ANTI-HANGOVER

Faa'iidada ugu weyn ee DHM waa ka hortagga iyo yareynta hangar-goysyada, si loo ilaaliyo beerkaaga iyo maskaxdaada. Tan waxaa lagu gaaraa kor u qaadida aalkoloda aalkolada (ADH) iyo acetaldehyde dehydrogenase (ALDH), kuwaas oo ah ensaziijiyada ugu weyn ee mas'uul ka ah jebinta aalkolada iyo acetaldehyde jirka.

Acetaldehyde gaar ahaan waa kiimikad sun ah oo sun ah isla markaana mid ka mid ah sababaha ugu weyn ee keena hangovers. Marka enzymes-kaan la kordhiyo, aalkolada iyo acetaldehyde waa loo burburin karaa si ka dhakhso badan sida caadiga ah.

CAAFIMAADKA CELLULAR

DHM waxay leedahay guryo caafimaad oo badan oo unugyo caafimaad ah kuwaas oo naftooda ku amaahan kara kobcinta caafimaadka garashada. Tani waxay dhacdaa maxaa yeelay DHM waxay kor u qaadaa heme-oxygenase-1 (HO-1), enzyme kaas oo xakameeya nabaad-guca heme isla markaana gudbisa guryaha caafimaadka. Dihydromyricetin sidoo kale waxay horumarin kartaa caafimaadka beerka.

Faa'iidooyinka kale ee loo yaqaan 'dihydromyricetin'

1) Dihydromyricetin wuxuu nadiifin karaa xagjirka jirka ee jirka iyo sunta ka hortaga

2) Dihydromyricetin wuxuu qaadan karaa Antibiotic Action

3) Dihydromyricetin-ka ayaa difaaci kara Beerka: Dihydromyricetin waxay leedahay talaabo adag oo xakameynaysa koritaanka ALT iyo AST dhiiga Serum. Waxay hoos u dhigi kartaa wadarta bilirubinka dhiiga. Markaa waxay leedahay talaabada adag ee hoos u dhigida aminotransferase iyo cagaarshow.

4) Dihydromyricetin wuxuu yareyn karaa heerarka sonkorta dhiigga iyo dufanka dhiigga: Dihydromyricetin waxay yareyn kartaa heerarka dufanka dhiigga ee jiirka. Waxay yareyn kartaa waxyeelada unugyada beerka ee ay keento heerarka dufanka dhiigga oo sare u kaca waxayna wanaajiso awoodda antioxidation. Isla mar ahaantaana, waxay yareyn kartaa heerarka sonkorta dhiigga ee sareysa.

5) Dihydromyricetin wuxuu noqon karaa Kahortagga caabuqa

6) Dihydromyricetin waxay ka hortagtaa buro-diidka: Budada soo saarida Dihydromyricetin waxay si habsami leh u xakameyneysaa unugyada burooyinka qaarkood.

Dhibaatooyinka falcelinta 'dihydromyricetin'.

Isku soo wada duuboo waxaa jira daraasado yar oo ilaa hada jira oo eegaya astaanta waxyeelada ee DHMs ilaa hadana wax dhibaato ah oo la soo sheegay lama soo sheegin.

Baadhitaan deg deg ah Amazon ayaa muujin doonta kumanaan dib u eegis ah. Markaad eegto iyaga, waxaa jira warbixino sheegaya calool xanuun, lallabbo, iyo shuban. Si kastaba ha noqotee, ma jiraan macaamiil badan oo soo sheega waxyeeladaan soo raaca.

Dihydromyricetin ayaa loo adeegsadaa lana adeegsadaa

Wuxuu isticmaalaa:

  1. Budada Dihydromyricetin loo isticmaalo ilaalinta beerka;
  2. Budada Dihydromyricetin loo adeegsaday habeynta duxda sonkorta dhiigga;
  3. Budada Dihydromyricetin waxay leedahay saameynta xoojinta difaaca jirka;
  4. Budada Dihydromyricetin oo leh shaqada antioxidant iyo kansarka ka hortagga;
  5. Budada Dihydromyricetin-ka loo isticmaalo antibiyootigga, daweeyo qufaca, xanuunka iyo baabi'inta sunta qiiqa.
  6. Dihydromyricetin-ka wuxuu leeyahay rajo wanaagsan oo horumarineed oo ku saabsan diyaarinta alaabada daryeelka-maqaarka ama dawooyinka loogu talagalay ka hortagga iyo daaweynta dhaawacyada maqaarka ee indhaha.

Codsiga

  1. Lagu dabaqay warshadaha quudinta, budada dihydromyricetin-ka loo isticmaalo sida ashyaa'da;
  2. Lagu dabaqay waxsoosaarka caafimaadka, budada dihydromyricetin-ka loo isticmaalo sidii ashyaa'da ceeriin ah si kor loogu qaado difaaca jirka;
  3. Waxaa lagu dabaqay maandooriyaha dawada, budada dareeraha ah ee loo yaqaan 'dihydromyricetin' budada loo isticmaalo oo loo isticmaalo kaabsoosha ama kaniiniyada lagu daaweeyo caabuqyada neef-mareenka iyo ilaalinta beerka.

Dihydromyricetin cilmi in Kahortaga Kansarka

Xaqiiqdii, waxaa jira xoogaa cilmi baaris ah oo quruxsan oo muujinaya in dihydromyricetin ay leedahay awood ay ku caawiso xaalad aan khamri la xiriirin oo loo yaqaan Hepatocellular carcinoma (HCC). HCC waa xaalad muujisa mid ka mid ah dhacdooyinka ugu sarreeya ee cudurrada iyo geerida adduunka oo dhan, waxayna soo bandhigaysaa nooca ugu weyn ee kansarka beerka ugu horreeya. Maaddaama DHM ay soo bandhigtay awood ilaalin ah oo ku saabsan beerka (waa daaweyn caafimaad) natiijooyinka ayaa shaaca ka qaaday inay si weyn u hor istaageyso fiditaanka unugyada iyo inay ku dhacdo unugyada loo yaqaan 'apoptosis cell' ee khadadka unugyada HCC, taasoo muujineysa in DHM ay tahay murashax ballan-qaad u leh daaweynta HCC.

Tixraaca:

Dihydromyricetin wuxuu yareyn doonaa dawada wadnaha ee dawada loo yaqaan 'doxorubicin-wadnaha' iyadoo la xakameynayo NLRP3 xannuunka iyada oo loo marayo firfircoonida SIRT1. Sun Z, Lu W, Lin N, Lin H, Zhang J, Ni T, Meng L, Zhang C, Guo H. Biochem Pharmacol. 2020 Feb 26: 113888. doi: 10.1016 / j.bcp.2020.113888. [Epub ka hor daabacaadda]

Daawada Metabolomics ee Kahortagga Ampelopsis grossedentata iyo Mawjad-weynaha firfircoon ee isku-darka Dihydromyricetin ee Beerka Cuntada dufanka badan ee Hilibka. Fan L, Qu X, Yi T, Peng Y, Jiang M, Miao J, Xiao P. Evid based Complement Alternat Med. 2020 Jan 28; 2020: 3472578. doi: 10.1155 / 2020/3472578. doorashada doorashada 2020.

Shuruucda dariiqyada tilmaanta ee Ampelopsin (Dihydromyricetin) ee kansarada kaladuwan: sahaminta wadooyinka waaween iyo jidadka yar ee la safray. Fayyaz S, Qureshi MZ, Alhewairini SS, Avnioglu S, Attar R, Sabitaliyevich UY, Buha A, Salahuddin H, Adylova A, Tahir F, Pawlak-Adamska E. Cell Mol Biol (Noisy-le-Grand). 2019 Sep 30; 65 (7): 15-20.

Dib-u-dejinta Golgi iyo xakamaynta borotiinnada 65 hoos u dhigga ayaa loo baahan yahay saamaynta ka hortagga kansarka ee dihydromyricetin ee unugyada kansarka ugxanta aadanaha. Wang F, Chen X, Yuan D, Yi Y, Luo Y.

PLoS Mid. 2019 Nov 26; 14 (11): e0225450. doi: 10.1371 / journal.pone.0225450. doorashada doorashada 2019.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.