Dufanka AICAR ee khamriga ah (2627-69-2)

December 29, 2018
SKU: 2627-69-2
5.00 ka mid ah 5 ku saleysan 1 macaamiisha rating

Budada AICAR, oo sidoo kale loo yaqaano riboside AICA, waa fiilo macaan oo leh hawlgal antineoplastic ah iyo firfircooni xulashada AMP-firfircoon ......


Status: Wax soosaarka Mass
Unugga: 25kg / Drum
Capacity: 1277kg / bishii

Daawada budada AICAR (2627-69-2)

Daawada budada AICAR (2627-69-2) Sharaxaad

Kalluunka AICAR oo sidoo kale loo yaqaanno ZMP waa analog AMP oo awood u leh inuu kiciyo waxqabadka kiniiniga AMP-ku tiirsan (AMPK). Dufanka AICAR waa mid dhexdhexaad ah jiilka of monofosphate inosine. Daawada budada AICAR waxaa loo adeegsadaa in lagu daaweeyo loona ilaaliyo dhaawaca wadnaha iskudhaca wadnaha, waxay geli kartaa unugyada wadnaha si loo joojiyo adenosine kinase iyo adenosine deaminase. Waxay kobcinaysaa heerka nukleotide dib u-soo-saarka kordhinta jiilka adenosine oo ka soo jeeda adenosine monophosphate oo keliya inta lagu jiro xaaladaha ischemia mareenka. Daawada budada AICAR waxay kor u qaadeysaa guluukoosta kor u qaadista adigoo ku dhejinaya sheyga GLUT4 iyo / ama ayadoo la adeegsanaayo wadada p38 MAPK. Xilligan, daroogada ayaa sidoo kale lagu muujiyey inay tahay daaweyn suurta gal ah in sonkorowga la kordhiyo dhaqdhaqaaqa jirka ee unugyada iyadoo la beddelayo qaabka jireed ee muruqa.

Dufanka AICAR ee khamriga ah (2627-69-2) Smamnuucista

Product Name Budada AICAR
Magaca Kiimikada 1-Ribosyl-4-Carboxamido-5-aminoimidazole, ARA 100, ARA-100, ARA100, GP 1 110, 5-aminoimidazole-4-Carboxamide 1-Ribofuranoside, 5-aminoimidazole-4-Carboxamide Riboside, acadesine, AICA ribofuranoside, AICA riboside, aminoimidazole carboxamide ribonucleoside, arasine, Z-riboside
brand NAme Wax macluumaad ah oo la heli karo
Fasalka Daroogada SARM
CAS Number 2627-69-2
InChikey RTRQQBHATOEIAF-UUOKFMHZSA-N
Molecular Formula C9H14N4O5
Molecular Wsideed 258.23
Monoisotopic Mass 258.096 g / mol
barafku Psaliid 214-215 ° C
Fdib u soo celinta Psaliid 214 ° C
Biological Life-Life Aad u gaaban
Color tan
SOlubility H2O:> 10 mg / mL
Storage Temperature -20 ° C
Budada AICAR Application Dhaqdhaqaaqa AMPK

Dufanka AICAR ee khamriga ah (2627-69-2)

Kalluunka AICAR ee loo yaqaan 'ZMP' waa analog of AMP, waa hawl-qaadaha unugyada, allosteric of AMP-activated kinase (AMPK). Waxay awood u leedahay inay dhiirrigeliso dhaqdhaqaaqa kiniiniga AMP-ku-tiirsan (AMPK), kordhinta kordhinta, kala duwanaanta iyo mineralization oo ah unugyada MC3T3-EI oo ka dhigaya muujinta cilmi-nafsiga ee cytokines iyo iNOS ee astrocytes.

Dufanka AICAR waa mid dhexdhexaad ah jiilka of monofosphate inosine. Daawada budada AICAR waxaa loo adeegsadaa in lagu daaweeyo loona ilaaliyo dhaawaca wadnaha iskudhaca wadnaha, waxay geli kartaa unugyada wadnaha si loo joojiyo adenosine kinase iyo adenosine deaminase. Waxay kobcinaysaa heerka nukleotide dib u-soo-saarka kordhinta jiilka adenosine oo ka soo jeeda adenosine monophosphate oo kaliya inta lagu jiro xaaladaha ischemia mareenka. Daawada budada AICAR waxay kor u qaadeysaa guluukoosta kor u qaadista adigoo ku dhejinaya sheyga GLUT4 iyo / ama ayadoo la adeegsanaayo wadada p38 MAPK. Xilligan, daroogada ayaa sidoo kale lagu muujiyey inay tahay daaweyn suurta gal ah in sonkorowga la kordhiyo dhaqdhaqaaqa jirka ee unugyada iyadoo la beddelayo qaabka jireed ee muruqa.

AICAR waa fiyuus la nadiifiyo waxqabadyada antineoplastic. Waa muhiim in la daaweeyo cudurrada dheef-shiid kiimikaad sida nooca sonkorowga 2 iyo sidoo kale daaweynta suurtagalka ah ee noocyada kala duwan ee kansarka.

Budada AICAR (2627-69-2) Mashruuca Hawlaha

Nucleoside ee AICAR, acadesi, waa analog of adenosine oo galaya unugyada wadnaha si loo joojiyo adenosine kinase iyo adenosine deaminase. Waxay kobcinaysaa heerka nukleotide dib u-soo-saarka kordhinta jiilka adenosine oo ka soo jeeda adenosine monophosphate oo kaliya inta lagu jiro xaaladaha ischemia mareenka. Cudurka maan-dooriyaha wadnaha, acadesi waa fosforylated AICAR si ay u-hawlgalaan AMPK iyada oo aan wax ka beddelin heerarka nucleotides. AICAR waxay awood u leedahay inay gasho jidka loo yaqaan 'de novo' ee loo yaqaan 'adenosine synthesis' si loo joojiyo adenosine deaminase taasoo keeneysa kororka heerarka ATP iyo heerarka adenosine.

Codsiga budada AICAR (2627-69-2)

▪ Antineoplastic

▪ Daroogada waxtarka leh ee kor u qaadaya

▪ Dhiiga kiciya ee guluukoosha

▪ Dhaqdhaqaaqa AMPK

▪ Cudurka dheef-shiid kiimikaadka

▪ Cudurka 'lymphoblastic' ee 'lymphoblastic'

talinayo Budada AICAR (2627-69-2)

Qiyaasta daawada AICAR waxay kala duwanaan kartaa xmUMX mg maalin kasta, haddii aad u gesho GW, ilaa qiyaasta 150 mg maalintii markaad u isticmaasho. Dhalada oo dhan waxay caadi ahaan ku dhacdaa xaddiga mgmaanka 500, sidaa daraadeed way cadahay qaali. Sababtan awgeed, waxa macquul ah in la isticmaalo afartii toddobaad ee ugu dambeysay ka hor maalinta tartanka.

Faa'iidooyinka Budada AICAR (2627-69-2)

♦ AICAR waa fiyuus furan oo leh hawlgal antineoplastic ah. Waa muhiim in la daaweeyo cudurrada dheef-shiid kiimikaad sida nooca sonkorowga 2 iyo sidoo kale daaweynta suurtagalka ah ee noocyada kala duwan ee kansarka.

♦ codsiga AICAR ee lagu daaweynayo xanuunada dheef-shiid kiimikaadka.

♦ AICAR waxay leedahay karti ku daweynaya daaweynta cudurka neuroinflammatory-ka kaas oo microglia-ka firfircooni ka ciyaara kaalin habboon.

♦ Caawinta AICAR si loo hagaajiyo mashiinka, shaqada xusuusta iyo shaqada maskaxda

♦ AICAR waxaa ugu wanaagsan in loo isticmaalo sidii loogu daro duldul qaadista. Ciyaartoyda ayaa sidoo kale u adeegsanaya waxtarka kor u qaadista cayaaraha halka ay u baahan yihiin dulqaad.

♦ AICAR waa analogue nucleoside oo awood u leh inuu galo pool nucleoside wuxuuna awoodaa inuu si weyn u kordho heerarka adenosine inta lagu jiro mudada ATP. Cudurrada Adenosine-regulating (ARAs) ayaa loo aqoonsaday in ay suurtogal tahay in lagu daweeyo iskudhexaha 'myocardial ischemia'.

♦ AICAR waxaa loo isticmaalaa daaweynta xanuunka lymphoblastic-ka ee laf-dhabarka waxaana lagu soo warramaa in ay leedahay saameynaha wadnaha wadnaha.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.