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Root Tadalafil budada (171596-29-5)

Budada Raw Tadalafil ee ku hoos jirta magaca 'Cialis' waxaa loo isticmaalaa in lagu daaweeyo cillad la’aanta (daciifnimo) iyo astaamaha qanjirka 'prostate'…


Status: Wax soosaarka Mass
Unugga: 25kg / Drum
Capacity: 1190kg / bishii

Description

Video Tadalafil budada

Macluumaadka Saldhiga

Product Name Budada Tadalafil
Magaca Kiimikada (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
brand NAme Cialis, Adcirca
Fasalka Daroogada PAH, PDE-5 Ka hortagga; Xakamaynta Fosfodiesterase-5 Enzyme
CAS Number 171596-29-5
InChikey WOXKDUGGOYFFRN-IIBYNOLFSA-N
Molecular Formula C22H19N3O4
Molecular Wsideed 389.4
Monoisotopic Mass 389.138 g / mol
barafku Psaliid 298-300 ° C
Fdib u soo celinta Psaliid 2 ℃
Biological Life-Life saacadood 17.5
Color Caddaan Caddaan-cad Cyrstalline Solid
SOlubility Isku-buufin DMSO (78 mg / ml at 25 ° C), methanol, biyaha (<1 mg / ml at 25 ° C), dichloromethane, iyo ethanol (<1 mg / ml at 25 ° C)
Storage Temperature Ku kaydi heerkulka qolka u dhexeeya 59 ° F iyo 86 ° F (15 ° C iyo 30 ° C). Ha ku keydin daawooyinkaan meelo qoyan ama qoyan.
Tadalafil Application Kiniiniyada budada xayawaanka Tadalafil, Nacnaca galmada, Qaxwaha, iwm.

Description

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4-b] indole-1,4-dione Cialis), waa nooc ka mid ah PDE5 inhibitor iyo daawo afka laga maamulo. Waa mid la soosaaray b-carboline waxayna qaab ahaan qaab ahaan uga duwan tahay vardenafil (Levitraw) iyo sildenafil (Viagraw), labaduba waa PDE5 inhibitors ku saleysan qaab dhismeedka aasaasiga ah ee loo yaqaan 'pyrimidine qaab dhismeedka'. Budada Tadalafil (CAS 171596-29-5) waxay kordhisaa qulqulka dhiigga galay corpus cavernosum adoo dejinaya muruqyada xididdada dhiigga, tanina waxay u saamaxeysaa nin inuu gaaro kac kac. Budada Tadalafil waxaa ogolaaday Maraykanka (US) Maamulka Cuntada iyo Dawooyinka (FDA) 2003 si loogu daweeyo naaquska (ED), suuqana looga suuq galiyo caalamka oo dhan magaca sumadda Cialis. Waxaa sidoo kale loo istcimaalaa in lagu daweeyo dhiig karka wadnaha iyo dhiig karka iyo qanjirada qanjirka 'prostate hyperplasia', oo ah xaalad qanjirka 'prostate' uu sii weynaado, taasoo keenta dhibaatooyinka kaadida.

Tadalafil ee farshaxanka farshaxanimada kala duwan ayaa ah nolosheeda nuska (saacadaha 17.5) marka la barbar dhigo Viagra iyo Levitra (saacadaha 4-5). Tani waxay sii kordheysaa nolosheeda nusqaayada ficil ahaan, waana, qayb ahaan, masuul ka ah naaneeysiga Cialis ee "kiniiniga usbuuca". Tani waxay sii dheer tahay noloshii badhkeed waxay sidoo kale saldhig u tahay baaritaanka hadda ee loo isticmaalo tadalafil isticmaalka hypertension hypertension sida daaweyn hal mar ah.

Mashruuca Hawlaha

Qalitaanka galmada inta lagu jiro dareenka galmada waxaa lagu gaari karaa nasinta qalitaanada galmada iyo muruqyada maskaxaha isku dhejisan, kaas oo keena in dhiigga kor u kaco orgiga. Niyadjabintan waxay u oggolaaneysaa in dhiiggu kor u kaco marinnada galmada, halka dhiiggu uu buuxiyo laba qol oo gudaha gudihiisa ah oo loo yaqaanno cavernosa. Marka qolalka dhiiggu ka buuxsamo, guska ayaa sii kordhaaya. Sifeynta ayaa soo afjartay marka muruqyada qandaraaska iyo dhiigga la uruuriyay ay ku faafi karaan xididdada galmada.

Jawaabtaan waxaa dhexdhexaadinaysa sii-deynta nitric oxide (MAYA) oo laga soo daayo xididdada dareemayaasha iyo unugyada endothelial, kuwaas oo kiciya isku-darka unugyada cGMP ee unugyada muruqyada jilicsan ka dibna xakameynaya isbeheysiga iyo kala-goysyada xididdada dhiigga ee geeya dhiigga ugana soo baxa. GMP cyclic GMP wuxuu sababayaa xasillooni muruqsan oo jilicsan iyo socodka dhiigga oo kordha oo ku dhaca corpus cavernosum, waxaana hoos u dhigay cGMP phosphodiesterase nooca 5 (PDE5) ee ku yaal galmada capnosum ee ku taal agagaarka guska. Tadalafil waxay xannibtaa PDE5 oo markaa ku sii xoojiyaa iyadoo la kordhinayo xaddiga cGMP ee la heli karo. Tadalafil waxay ka joojineysaa PDE5 burburinta cGMP ka dibna waxay kordhisaa cGMP la heli karo si loo gaaro shaqeynta waxayna sababtaa kacsiga inuu sii dheeraado.

Si kastaba ha ahaatee, nolosha Tadalafil waa mid gaaban, saameynteeda waxay gashaa xilliga maalmaha 2 ee samaynta PDE5 soo laabashada iyo caafimaadka galmadaaga - ka sii dar. Waxaa laga yaabaa inaad u baahan tahay inaad qaadato wakhti dheer si aad u xaqiijiso saameynta aad rabto, sida xoogaa xoogan ee Cialis 4-5 maalmaha 4-5.

Codsiga

  • Dheef la'aan (ED)
  • Dhiig-xoojinta sambabada
  • Dhiig-qanjirka 'prostatic hyperplasia'
  • Analgesic
  • Norepinephrine kor u qaadaha xannibista
  • Mudaaharaade Mufti

Talooyin Tadalafil lagu taliyay

Cialis waxay ku timaadaa jaale, jilicsan iyo kiniin ah oo kiniin ah oo ku jira 5, 10 iyo 20 milligram (mg). Talaalka bilowga ah ee lagu taliyey ee budada Cialis ee loogu talagalay isticmaalka sida loogu baahan yahay bukaannada intooda badan waa 10 mg, ka hor inta aan la fileynin hawsha galmada.

Qiyaasta ugu horreysa waa miliishiyada 10 (mg) ugu yaraan daqiiqado 30 ka hor inta aan la sameynin ficil galmo. Qaadadu waxay kordhin kartaa x mgka 20 ama waxay hoos u dhigtay mgmaanka 5, oo ku saleysan shaqsiyadeed iyo dulqaad. Hase yeeshee, ugu badnaan waa xajmiga 20 sida hal dose. Jadwalka qiyaasta ugu badan ee lagula taliyay ayaa ah hal mar maalintii bukaanka badankood. waa in aysan aheyn in aan ka badneyn hal qiyaasta saacadaha 24. Bukaanka filaya inay galmo ahaan firfircoon yihiin ugu yaraan laba jeer toddobaadkiiba waxay qaadan karaan qadar maalinle ah oo ah 5 mg, waxaana tani lagu yareyn karaa mgmarka 2.5 mar maalintii, iyadoo ku xiran dareen-celinta shakhsiyeed.

Budada Cialis ee loo isticmaalo sidii loogu baahnaa ayaa la muujiyay si loo wanaajiyo shaqada marka loo barbar dhigo placebo illaa 36 saacadood kadib qaadashada. Sidaa darteed, markii lagala talinayo bukaannada isticmaalka ugu fiican ee budada Cialis, tan waa in la tixgeliyaa.

Waxaa xusid mudan in kacsigu uusan ku dhici doonin kaliya qaadashada kaniiniga. Oo ha u qaadanin Cialis dhiig-bax haddii aad u qaadanayso Adcirca dhiig karka sambabada. Marka laga soo tago, Tadalafil oo loogu talagalay dysfunction waxaa keliya oo loo isticmaali karaa dadka waaweyn oo da'doodu tahay 18 sano iyo wixii ka sareeya.

Faa'iidooyinka

♦ Maaddada Tadalafil waxay kaa caawin kartaa inaad murqaha ku nasto qanjirkaaga kaadi haysta iyo kaadiheystaada. Tani waxay kaa caawin kartaa hagaajinta calaamadahaaga BPH.

♦ Si loo wanaajiyo calaamadaha ED, budada tadalafil waxay kor u qaadaa kor u qaadista dhiigga guska. Tani waxay kaa caawin kartaa inaad hesho oo aad sii wadato koritaanka. Si aad u isticmaasho budada tadalafil si ay kuugu caawiso inaad kacsanaato, waxaad u baahan tahay inaad galmo ku kacdo.

♦ For PAH, budada tadalafil waxay u shaqaysaa si ay u hagaajiso kartidaada jimicsi adiga oo ku nasteexo marinnada dhiigga ee sanbabadaada. Tani waxay kordhisaa socodka dhiigga.

Dhibaatooyinka ay keento

Marka la raaco saameyntiisa loo baahan yahay, daawadu waxay keeni kartaa waxyeelo aan la rabin. In kasta oo aaney dhammaan saameynada daaweyntu dhici karaan, haddii ay dhacaan waxay u baahan karaan daryeel caafimaad. Fadlan hubi waxyeelooyinka soo socda ee budada tadalafil:

Waxyeellooyinka guud ee caadiga ah

▪ madax xanuun

▪ calool xanuun

▪ xanuunka dhabarka

▪ murqo xanuun

▪ Maydhista (maqaarka guduudan)

▪ sanka oo duufsan ama duufsan

▪ Shuban

Dhibaatooyin halis ah oo culus

Dheecaan dheer oo keeni kara in uu waxyeelo u geysto guska, dhibaatooyinka aragtida, iyo maqal la'aanta.

Haddii saameyntan ay tahay mid khafiif ah, waxaa laga yaabaa inay tagaan maalmo yar ama dhowr toddobaad. Haddii ay aad u daran yihiin ama aadan tagin, la hadal dhakhtarkaaga ama farmashiistaha.

Dadka qaba xaaladdahan soo socda waa inaysan qaadan budada Cialis ilaa dhakhtarku ogolaado:

Dhibaatooyinka wadnaha ee wadnaha, angina, ama nooc kasta oo ah wadnaha wadnaha

Cadaadiska dhiigga ee sareeya ama hoos u dhaca

Qalabka wadnaha ee ku dhaca wadnaha ama istaroogga ee bilihii ugu dambeeyay ee 6, ama infekshanka miyir-beelka ee bilihii ugu dambeeyay ee 3

Unugyada unugyada unugyada dhiigga ku dhaca, unugyada multiple myeloma, hemophilia, leukemia, ama cudur kale oo dhiig ah

Cudurka beerka ama kelyaha

Boogta caloosha

Retinitis pigmentosa

Dhiigga qaabdhismeedka guska, sida cudurka Peyronie

Xaalad kasta oo caafimaad ee lagula taliyay in aysan galmo galmo sameynin

Isdhexgalka Tadalafil

Markaad isticmaasho tadalafil, waxaa jiri kara daroogo kale oo saameyn kara daroogada, taas oo keeni karta saameynaha. Isdhexgalka daroogada ayaa isbedeli kara sida daawooyinkaagu u shaqeeyaan ama u kordhiyaan khatartaada waxyeelo halis ah.

Tadalafil waxay leedahay saameyn isku dhafan oo ku salaysan yaraanta nitrate-ku sababtay cadaadiska dhiigga. Tadalafil waxay sababi kartaa hoos u dhac ku yimaada cadaadiska dhiiggaaga marka loo isticmaalo nitrates, taas oo keeni karta dawakhaad, suuxdin, iyo mararka qaar wadnaha ama istaroogga. Ha isticmaalin tadalafil mid kasta oo ka mid ah kuwan soo socda: Daawooyinka qaarkood oo loo isticmaalo daaweynta xanuunka / angina (nitrates sida nitroglycerin, isosorbide), daawooyinka madadaalada ee loo yaqaan "poppers" oo ay ku jiraan amyl ama nitrite nitrite.

Haddii aad sidoo kale qaadato dawada xayawaanka (sida doxazosin, tamsulosin) si loo daaweeyo qanjidh-ka 'prostate' / BPH ama cadaadis dhiig oo sarreeya, cadaadiska dhiiggaagu wuu yaraan karaa taas oo horseedi karta dawakhaad ama suuxdin. Takhtarkaaga ayaa laga yaabaa inuu bilaabo daaweyn qadar yar oo tadalafil ah ama lagu hagaajiyo dawadaada caagaga ah ee xajinta si loo yareeyo khatarta dhiig kar.

Daraasadaha cisbitaalada, heerarka waxtarka badan ee jawaabta ayaa la soo sheegay ilaa 36 h ka dib markii la bilaabay daroogada. Tadalafil waxaa sida caadiga ah lagu duraa beerka iyadoo la adeegsanayo CYP3A4 hay'adaha aan firfircoonayn ka dhanka ah PDE5 oo inta badan loo yaqaan 'metabolites' ee saxarada iyo kaadida. Farmashiistaha dawooyinka ee tadalafil wax saameyn ah kuma yeelan arrimaha sida qaadashada cuntada iyo aalkolada, da'da, jiritaanka sonkorowga, iyo yaraanta hepatic dhexdhexaad ah ama dhexdhexaad ah. Dhacdooyinka ugu caansan ee laxiriira dawooyinka waa madax xanuun, dhabar xanuun, dyspepsia, iyo myalgia. Qiyaasta 10 iyo 20 mg qiyaasta, Tadalafil wax saameyn weyn ah kuma leh cadaadiska dhiigga iyo garaaca wadnaha mana dhaliso in ay kordhaan xaaladaha myocardial infarction. Warbixinno dhif ah oo ku saabsan dhismeyaal daba dheeraaday oo ka weyn 4 h iyo 'kadifaaca' ayaa lagu xusay isticmaalka tadalafil. Firfircoonaanta, haddii aan si habboon loo daaweyn, waxay ku dambayn kartaa waxyeelo aan laga beddeli karin unugyada. Bukaanka leh kacsanaan waara oo ka weyn 4 h ayaa lagula talinayaa inay raadsadaan daryeel caafimaad oo degdeg ah. Bukaanka sokorowga, kor u qaadida shaqada by tadalafil waa iyadoo aan loo eegin nooca cudurka macaanka iyo nooca daaweynta sonkorowga.

Daawooyinka kale waxay saameyn karaan ka saarista tadalafil jirkaada, taas oo saameyn karta sida tadalafil u shaqeeyo. Tusaale ahaan waxaa ka mid ah antibungal (azraxonazole, ketoconazole), antibiotics macrolide (sida cadithromycin, erythromycin), qufacaanka HIV protease (sida fosamprenavir, ritonavir), hepatitis C virus protease inhibitor (sida boceprevir, telaprevir), rifampin, iyo kuwa kale .

Ha u qaadan dawadan waxkastoo kale oo ay kujiraan kor u kaca kor u kaca ama dawooyinka kale ee la midka ah ee loo isticmaalo daweynta dysfunction-ED ama dhiig karka (sida sildenafil, vardenafil).

Marka laga hadlayo daaweynta tadalafil oo kale daawooyinka kale ayaa weli leh wax badan, haddii aad rabto inaad isticmaasho daroogada leh budada tadalafil (CAS 171596-29-5), marka hore xusuuso inaad dhakhtarkaaga la tashato oo wuxuu ku siin doonaa talo xirfad leh oo la isku halleyn karo.

Wixii macluumaad dheeraad ah

Budada Tadalafil, budada sildenafil, iyo budada vardenafil oo dhan waxay ku dhaqmaan by la yiraahdo PDE5 enzyme, laakiin daroogooyinka ayaa sidoo kale xakameynaya enzymes PDE 6, 1, iyo 11 heerar kala duwan. Tusaale ahaan, Sildenafil iyo vardenafil waxay joojinayaan PDE6, enzim laga helo isha, wax ka badan tadalafil. Qaar ka mid ah dadka isticmaala sildenafil waxay arkayaan tinge buluug ah waxayna leeyihiin dareen xoog leh oo iftiin leh sababtoo ah PDE6 hortaagan. Ka sokow, Sildenafil iyo vardenafil ayaa sidoo kale xakameynaya PDE1 ka badan tadalafil. PDE1 waxaa laga helaa maskaxda, wadnaha, iyo muruqyada isku xiga. Waxaa loo maleynayaa in xakamaynta PDE1 ay sildenafil iyo vardenafil ay keenaan dheecaan, daadinta, iyo taakulada.

Marka loo barbardhigo waxqabadka PDE6 iyo PDE1, tadalafil wuxuu si aad ah u abuurnaa PDE11. PDE11 waxaa lagu muujiyay muruqa qalfoofka, prostate, beerka, kalyaha, qanjirka pituitary, iyo baaritaanka. Si kastaba ha noqotee, saameynta jidhka ee ka hortagga PDE11 lama yaqaan.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


Tixraacyada iyo xaashiyadaha alaabada

tixraacyada

  • 1 Xarunta Macluumaadka Biotechnology, US. Maktabadda Qaranka ee Daawada, Tadalafil, Qaybta Pubchem 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Isticmaala, Qiyaasta, Waxyeelada Waxyeelada ah iyo Xaggee Gadashada Guud ahaan Cialis (Tadalafil), Viagra (Sildenafil), iyo Mukhaadaraadka Kale ee Fiican Lacag Fiican oo Amaana ah Khatarsan, Safar, 13 Dec 2017, bog 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: Daawooyinka Erectile Disruption, Calaamadaha Benign Prostatic Hyperplasia, iyo Pulmonary Arterial Hypertension, Abuurista Daabacaadda Madaxbannaan, 26 Mar 2015, bogga 5-47.