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Ganglioside GT1b (59247-13-1)

Magaca Ganglioside waxaa markii ugu horreysey u isticmaalay saynisyahan Jarmal Ernst Klenk sanadkii 1942 looguna magac daray lipids go'yaal cusub oo ka yimid unugyada burcadka maskaxda… ..


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

Ganglioside GT1b Smamnuucista

Product Name Ganglioside GT1b
Magaca Kiimikada GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) oo ka timaadda maskaxda bovine; trisialoganglioside-gt1b laga soo bilaabo maskaxda bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + cusbo)
CAS Number 59247-13-1
InChikey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Formula kelli C95H162N5Na3O47
Miisaanka kelli 2158.4 g / mol
Monoisotopic Mass 2157.119189 g / mol
Dhibicda Biyaha N / A
Skulayl daran -20 ° C
milmi DMSO: soluble
Codsiga Daawada; koromograafiga;

waa maxay Ganglioside GT1b?

Magaca Ganglioside waxaa markii ugu horreysay u isticmaalay saynisyahan Jarmal ah Ernst Klenk sanadkii 1942 looguna magac daray lipids unugyada unugyada maskaxda ee maskaxda. Waa molecule ka kooban glycosphingolipids (ceramides iyo oligosaccharides) iyo hal ama insiic acids saalic oo ku xiran silsilad sonkor ah. Waxay ka kooban tahay xuubka cytoplasmic xuubka kaas oo habeeya dhacdooyinka wareejinta calaamadaha unugyada. In ka badan 60 nooc oo ah kuwa loo yaqaan 'gangliosides' ayaa la yaqaan, iyo farqiga ugu weyn ee u dhexeeya iyaga waa booska iyo tirada harsan ee NANA.

Ganglioside GT1b waa mid ka mid ah gangliosides badan waana trisialic ganglioside oo leh laba hadhaaga acid sialic oo ku xiran unug galactose gudaha ah. Waxay ku leedahay saameyn xakameysan jawaab celinta difaaca jirka ee jidhka. Markay tahay 0.1-10 μM, waxay horjoogsan kartaa soo-saarka lafdhabarta ah ee IgG, IgM iyo IgA unugyada wareegga dhiigga ee bini aadamka. Ganglioside GT1b ayaa sidoo kale loo soo jeediyay inuu yahay marti qaade martigeliye unugyada Merkel unugyada unugyada Merkel unugyada unugyada isla markaana loo adeegsado inay kiciyaan cudurrada sababa cudurka unugyada 'Merkel cell carcinoma'.

Ganglioside GT1b sidoo kale waxaa lagu sameeyay dhowr kansar oo neuronal ah waxaana loo arkaa inuu yahay ganglioside la xiriirta metastases maskaxda. Daraasaduhu waxay ogaadeen in GM1, GD1a, iyo GT1b ay leeyihiin saameyn laxiriira oo kudhaca calaamadaha receptor koritaanka epidermal iyo guuritaanka iyo keratinocytes, jiritaankooduna waxay noqon karaan bayoloji faa iido leh oo lagu qiimeeyo awooda maskaxda.

Ganglioside GT1b sidoo kale waxay saameyneysaa nidaamka difaaca jirka. Ganglioside GT1b waxay leedahay saameyn aan la taaban karin ee jawaab celinta difaaca jirka ee bini-aadamka waxayna xaddideysaa immunoglobulins-ka ay soo saarto unugyada mononuclear-ka dhiigga ee bini-aadamka. Waxaa jira caddeyn ah in GD1b, GT1b, iyo GQ1b ay kor u qaadi karaan wax soo saarka Th1 cytokines iyagoo xakameynaya waxqabadka adenylate cyclase, halka ay horjoogsanayaan soosaarka Th2.

Sida soo dhaweynaya oo garta sunta kala duwan ee qaab dhismeedka oligosaccharide, ganglioside GT1b waa receptor kaas oo Clostridium botulinum bakteeriyada botulinum neurotoxin ay gasho unugyada dareemeyaasha. Daraasado la sameeyay ayaa muujiyey in sunta tetanus ay gasho unugyada dareemeyaasha iyadoo ay weheliso kuwa loo yaqaan 'GT1b' iyo kuwa kale ee loo yaqaan 'gangliosides', waxay joojineysaa sii deynta neurotransmitters-ka ee nidaamka neerfaha dhexe, waxayna u horseedaa curyaannimo. Nooca botulinum nooca C neurotoxin ee galaya dareemeyaasha ayaa baaray saameynta suurtagalka ah ee apoptotic ee unugyada ay soo saareen 'ganglioside GT1b' oo ku xirma neuroblastoma.

Intaa waxaa sii dheer, ganglioside GT1b waxay si xun u habeynaysaa dhaqdhaqaaqa unugyada, kala-goynta, iyo u-dheelitirka fibronectin (FN) iyada oo loo marayo is-dhexgalka molikalikada tooska ah ee 'sub5 subunit' ee β5β1 integrin, helitaan loo adeegsan karo in lagu horumariyo daweynta kansarka. Isku-darka GT1b iyo MAG dusha sare ee neerfaha ayaa sidaas awgeed u habeyn kara is-dhexgalka GT1b ee xuubka Plasma ee neurons-ka, taasoo keentay in la xakameeyo koritaanka neerite-ka.

Faa'iidooyinka Ganglioside GT1b

Ganglioside GT1b waa aashito glycosphingolipid kaas oo sameeya unugyo firfircoon oo ka dhiga unugyada neerfayaasha ee nidaamka neerfaha bartamaha oo ku lug leh kororka unugyada, kala duwanaanshaha, isku duubnaanta, wareejinta calaamadaha, is-dhexgalka unugyada, buroigenesis, iyo metastasis.

Jawaabaha Autoimmune ee kooxaha burcadda waxay horseedi karaan cudurka Guillain-Barre. Ganglioside GT1b ayaa kadhigaysa yaraanshaha dopaminergic neuron, oo wax ku biirin kara bilawga ama horumarka cudurka Parkinson.

'Ganglioside GT1b' waa mid ka-shaqeeyaa xag-jirka • OH bilaash ah, oo ka ilaaliya maskaxda waxyeellada mtDNA, suuxdinta iyo hoos u dhaca lipid peroxidation ee ay dhaliyaan matoorrada firfircoon ee firfircoon.

Burooyinka Ehrlich waxay muujinayaan gang1ioside GT1b, iyo anti-GTXNUMXb waxay leedahay awood weyn oo daweyn ah oo kansar ah. Xannuunkan 'ganglioside' wuxuu kaloo la xiriiraa cudurka Miller Fisher syndrome.

Dhibaatooyinka soo raaca Ganglioside GT1b

Gangliosides wuxuu ku dhejin karaa lectins, wuxuu u dhaqmaa sidii difaac iyo unugyada adhesion receptors, kaqeybgalida calaamadaha unugyada, cudurka kansarka iyo kala duwanaanshaha unugyada, waxay saameyn ku yeeshaan samayska mandheerta iyo koritaanka dareemeyaasha, waxay ka qeybqaataan xasilloonida myelin iyo dib u soo cusbooneysiinta dareemayaasha, waxayna u dhaqmaan sida faayras iyo barta galitaanka sunta unugyada .

Ururinta 'ganglioside GT1b' ayaa lala xiriiriyay dhowr cudur oo ay ka mid yihiin cudurka Thai-Sachs iyo cudurka Sandhof.

Ganglioside GT1b waxay joojineysaa jawaab celinta unugyada taranka ee antigen ama mitogen-indu waxaana loo aqoonsaday helitaanka sunta botulinum, oo ah sun aad u yar oo cawaaqib xumo jir ahaaneed leh.

Ganglioside GT1b ayaa inta badan ku jira unugyada dareemeyaasha waxaana lagu muujiyey adventitia. GT1b waxay sare u qaadeysaa kaladuwanaanshaha neuronal iyo sameynta dendritic, taas oo soo saarta dabeecad aan walwal laheyn isla markaana xoojisa hyperalgesia iyo allodynia.

Ganglioside GT1b waxay saameyn ku yeelan kartaa nidaamka difaaca jirka. Waxay ku leedahay saameyn xakameyn ah jawaabta difaaca jirka ee bini'aadamka waxayna xaddideysaa immunoglobulin ee ay soo saarto unugyada dhiigga ee mononuclear unugyada.

Ku darista, Ganglioside GT1b waxay la xiriirtaa cudurada soo socda: hargabka, guillain – garré syndrome, daacuunka, teetanada, botulism, baraska iyo cayilka.

Tixraaca:

  • Erickson, KD, Garcea, RL, iyo Tsai, B. Ganglioside GT1b waa hoyga loo yaqaan 'hostative receptionor unugyada' Merkel cell polyomavirus '. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., iyo Tamaki, K. Ganglioside GT1b waxay joojineysaa soosaarka immunoglobulin ee unugyada unugyada dhiigga ee mononuclear. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, iyo Ringler, NJ Binging botulinum iyo tetanus neurotoxins to ganglioside GT1b iyo aasaasayaasheeda. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, qaab dhismeedka, dhacdada, bayoolaji iyo falanqaynta ”. Maktabadda Lipid. The American Chemists 'Society. Waxa laga keydiyay asalkii 2009-12-17.
  • Nicole Gaude, joornaalka cilmiga kimikalka, Vol. 279: 33 p. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, iwm. Biosynthesis oo ka mid ah kuwa ugu waaweyn ee loo yaqaan 'gang gangiosios GD1a' iyo GT1b. Glycobiology, mugga 22, cadadka 10, Oktoobar 2012, bogagga 1289–

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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Fiidiyowga Ganglioside GT1b (59247-13-1)

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