Ganglioside GT1b (59247-13-1)

March 15, 2020

Magaca Ganglioside waxaa markii ugu horeysay adeegsaday saynisyahan Jarmal ah Ernst Klenk sanadii 1942 si loo siiyo baruurta dhowaan laga soocay unugyada ganglion maskaxda… ..

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Fiidiyowga Ganglioside GT1b (59247-13-1)

Ganglioside GT1b Smamnuucista

Product Name Ganglioside GT1b
Magaca Kiimikada MALALKA GANGLIOSIDE GT1B TRISODIUM; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) oo laga helo maskaxda bovine; trisialoganglioside-gt1b oo laga helo maskaxda bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + cusbo)
CAS Number 59247-13-1
InChikey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Formula kelli C95H162N5Na3O47
Miisaanka kelli 2158.4 g / mol
Monoisotopic Mass 2157.119189 g / mol
Dhibicda Biyaha N / A
Skulayl daran -20 ° C
milmi DMSO: waa la milmi karaa
Codsiga Daawada; koromograafiga;

 

waa maxay Ganglioside GT1b?

Magaca Ganglioside waxaa markii ugu horreysay adeegsaday saynisyahan Jermal ah Ernst Klenk sanadkii 1942 si loogu sameeyo baruurta dhowaan laga soocay unugyada ganglion maskaxda. Waa molecule ka kooban glycosphingolipids (ceramides iyo oligosaccharides) iyo hal ama in ka badan oo ah asiidh sialic ah oo ku xiran silsilad sonkor ah. Waa qayb ka mid ah xuubka cytoplasmic ee nidaamiya dhacdooyinka gudbinta calaamadaha unugyada. In kabadan 60 nooc oo gangliosides ah ayaa la yaqaan, farqiga ugu weyn ee udhaxeeyaa waa booska iyo tirada haraaga NANA.

Ganglioside GT1b waa mid ka mid ah gangliosides badan waana ganglioside trisialic ah oo leh laba haraaga sialic acid oo ku xiran unug galactose gudaha ah. Waxay leedahay saameyn xaddidan oo ku saabsan jawaab celinta difaaca jirka ee jirka. Qiyaasta 0.1-10 μM, waxay horjoogsan kartaa wax soo saarka isdaba jooga ah ee IgG, IgM iyo IgA unugyada unugyada mononuclear-ka ee jirka. Ganglioside GT1b sidoo kale waxaa loo soojeediyey inuu noqdo soo dhoweeyaha unugga martida ee virus cell polyoma iyo waliba qaab awood u leh inuu kiciyo caabuqyo sababa Merkel cell carcinoma

Ganglioside GT1b sidoo kale waxaa lagu sameeyay dhowr kansar oo neuronal ah waxaana loo arkaa inuu yahay ganglioside la xiriirta metastases maskaxda. Daraasaduhu waxay ogaadeen in GM1, GD1a, iyo GT1b ay leeyihiin saameyn laxiriira oo kudhaca calaamadaha receptor koritaanka epidermal iyo guuritaanka iyo keratinocytes, jiritaankooduna waxay noqon karaan bayoloji faa iido leh oo lagu qiimeeyo awooda maskaxda.

Ganglioside GT1b sidoo kale waxay saameysaa nidaamka difaaca jirka. Ganglioside GT1b waxay leedahay saameyn xaddidan oo ku saabsan jawaab celinta difaaca jirka ee bina-aadamka waxayna xakameysaa immunoglobulins-ka ay soo saaraan unugyada jirka ee unugyada mononuclear. Waxaa jira cadeymo muujinaya in GD1b, GT1b, iyo GQ1b ay kor u qaadi karaan soosaarka cytokines-ka Th1 iyagoo xakameynaya waxqabadka adenylate cyclase, iyadoo la joojinayo soosaarka Th2.

Sida soo dhaweynaya oo garta sunta kala duwan ee qaab dhismeedka oligosaccharide, ganglioside GT1b waa receptor kaas oo Clostridium botulinum bakteeriyada botulinum neurotoxin ay gasho unugyada dareemeyaasha. Daraasado la sameeyay ayaa muujiyey in sunta tetanus ay gasho unugyada dareemeyaasha iyadoo ay weheliso kuwa loo yaqaan 'GT1b' iyo kuwa kale ee loo yaqaan 'gangliosides', waxay joojineysaa sii deynta neurotransmitters-ka ee nidaamka neerfaha dhexe, waxayna u horseedaa curyaannimo. Nooca botulinum nooca C neurotoxin ee galaya dareemeyaasha ayaa baaray saameynta suurtagalka ah ee apoptotic ee unugyada ay soo saareen 'ganglioside GT1b' oo ku xirma neuroblastoma.

Intaa waxaa sii dheer, ganglioside GT1b waxay si xun u habeynaysaa dhaqdhaqaaqa unugyada, kala-goynta, iyo u-dheelitirka fibronectin (FN) iyada oo loo marayo is-dhexgalka molikalikada tooska ah ee 'sub5 subunit' ee β5β1 integrin, helitaan loo adeegsan karo in lagu horumariyo daweynta kansarka. Isku-darka GT1b iyo MAG dusha sare ee neerfaha ayaa sidaas awgeed u habeyn kara is-dhexgalka GT1b ee xuubka Plasma ee neurons-ka, taasoo keentay in la xakameeyo koritaanka neerite-ka.

 

Faa'iidooyinka Ganglioside GT1b

Ganglioside GT1b waa aashito glycosphingolipid kaas oo sameeya unugyo firfircoon oo ka dhiga unugyada neerfayaasha ee nidaamka neerfaha bartamaha oo ku lug leh kororka unugyada, kala duwanaanshaha, isku duubnaanta, wareejinta calaamadaha, is-dhexgalka unugyada, buroigenesis, iyo metastasis.

Jawaabaha autoimmune ee gangliosides waxay u horseedi karaan cudurka Guillain-Barre syndrome. Ganglioside GT1b waxay ku dhacdaa dopaminergic neuron xumaanshaha, taas oo gacan ka geysan karta bilowga ama horumarinta cudurka Parkinson.

'Ganglioside GT1b' waa mid ka-shaqeeyaa xag-jirka • OH bilaash ah, oo ka ilaaliya maskaxda waxyeellada mtDNA, suuxdinta iyo hoos u dhaca lipid peroxidation ee ay dhaliyaan matoorrada firfircoon ee firfircoon.

Burooyinka Ehrlich waxay muujinayaan gang1ioside GT1b, iyo anti-GTXNUMXb waxay leedahay awood weyn oo daweyn ah oo kansar ah. Xannuunkan 'ganglioside' wuxuu kaloo la xiriiraa cudurka Miller Fisher syndrome.

 

Dhibaatooyinka soo raaca Ganglioside GT1b

Gangliosides wuxuu ku dhejin karaa lectins, wuxuu u dhaqmaa sidii difaac iyo unugyada adhesion receptors, kaqeybgalida calaamadaha unugyada, cudurka kansarka iyo kala duwanaanshaha unugyada, waxay saameyn ku yeeshaan samayska mandheerta iyo koritaanka dareemeyaasha, waxay ka qeybqaataan xasilloonida myelin iyo dib u soo cusbooneysiinta dareemayaasha, waxayna u dhaqmaan sida faayras iyo barta galitaanka sunta unugyada .

Ururinta 'ganglioside GT1b' ayaa lala xiriiriyay dhowr cudur oo ay ka mid yihiin cudurka Thai-Sachs iyo cudurka Sandhof.

Ganglioside GT1b wuxuu joojiyaa antigen ama jawaab celinta faafa ee unugyada T cell waxaana loo aqoonsaday inuu yahay soo-dhowe botulinum ah, sun dhif ah oo leh cawaaqib xumo jireed.

Ganglioside GT1b waxay ku jirtaa gebi ahaanba unugyada neerfaha waxaana lagu muujiyaa adventitia. GT1b waxay dhiirrigelisaa kala-duwanaanta neerfaha iyo sameynta dendritic, oo soo saarta dabeecad xun waxayna xoojisaa hyperalgesia iyo allodynia.

Ganglioside GT1b waxay saameyn ku yeelan kartaa nidaamka difaaca jirka. Waxay leedahay saameyn xaddidan oo ku saabsan jawaab celinta difaaca jirka ee bina-aadamka waxayna xakameysaa tallaalka immunoglobulin ee ay soo saaraan unugyada unugyada mononuclear-ka ee dhiigga.

Marka lagu daro, Ganglioside GT1b waxay la xiriirtaa cudurada soo socda: hargabka, guillain-garré syndrome, daacuunka, teetanada, botulism, baraska iyo buurnaanta.

 

Tixraaca:

  • Erickson, KD, Garcea, RL, iyo Tsai, B. Ganglioside GT1b waa hoyga loo yaqaan 'hostative receptionor unugyada' Merkel cell polyomavirus '. Journal of Virology 83 (19), 10275-10279 (2009).
  • Kanda, N., iyo Tamaki, K. Ganglioside GT1b waxay joojineysaa soosaarka immunoglobulin ee unugyada unugyada dhiigga ee mononuclear. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, iyo Ringler, NJ Binging botulinum iyo tetanus neurotoxins to ganglioside GT1b iyo aasaasayaasheeda. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, qaabdhismeedka, dhacdada, bayoolajiga iyo falanqaynta ”. Maktabada Lipid Bulshada American Chemists Chemists. Laga keydiyay asalka markay ahayd 2009-12-17.
  • Nicole Gaude, joornaalka cilmiga kimikalka, Vol. 279: 33 p. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, iwm. Biosynthesis ee gangliosides weyn ee maskaxda GD1a iyo GT1b. Glycobiology, Volume 22, Issue 10, October 2012, Bogagga 1289–