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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) waa soo-dhaweynta peroxisome proliferator-firfircoon-ka-shaqeysta recepor alfa (PPAR-alpha) agonist. Waa …… ..


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

Oleoylethanolamide (OEA) (111-58-0) Faahfaahinta

Product Name Oleoylethanolamide (OEA)
Magaca Kiimikada n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChikey BOWVQLFMWHZBEF-KTKRTIGZSA-N
dhoolla caddayntaada CCCCCCCCC = CCCCCCCCC (= O) NCCO
Formula kelli C20H39NO2
Miisaanka kelli 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Dhibicda Biyaha 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Boiling Point 496.4 ± 38.0 ° C (Saadaaliyay)
mugga 0.915 ± 0.06 g / cm3 (Saadaaliyay)
Color White
Skulayl daran -20 ° C
Ku adkaanshaha ethanol iyo DMSO Xalka
Codsiga Qeybta Phamaceutical; xirmooyin;

Waa maxay Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) waa soo-dhaweynta peroxisome proliferator-firfircoonaanta recepor alfa (PPAR-alpha) agonist. Waa dabiici ku dhaca glycolamide lipid oo leh noocyo kala duwan oo guryo leh homeostasis sida xakamaynta rabitaanka cuntada, dhaqdhaqaaqa ka hortagga bararka, kicinta lipolysis iyo sunta aashitada dufanka leh. Oleoylethanolamide waxaa loo tixgelin karaa hormoon ah dhidibka maskaxda xiidmaha. Oatmeal, nuts, iyo budada kookaha ayaa ah ilaha ugu waaweyn ee cuntada Oleoylethanolamide ee cuntada. Si kastaba ha noqotee, qadarka Oleoylethanolamide ee laga helo cuntooyinkan ayaa hooseeya (in ka yar 2 µg / g).

Maaddaama ay tahay dhexdhexaad firfircoon oo leh nafley, oleylethanolamide (OEA) waxaa lagu soo saaraa xiidmaha iyo unugyada kale, waxayna ku lug leedahay qaanuunka dheellitirka tamarta naasaha, xakameynta qaadashada cuntada iyo dheef-shiid kiimikaadka, sida waxay habeyn kartaa cuntada Vertebrate iyo culeyska jirka. Oleoylethanolamide waa aashitada ethanolamide ee dufanka leh (FAE), oo ah analog-ga analogam ee loo yaqaan 'endocannabinoid arachidonic acid ethanolamide (anandamide), iyo shaqeyste ka soo horjeedda anandamide. Waxaa xusid mudan in Oleoylethanolamide uu ka duwan yahay anandamide, way ka madax bannaan tahay soo-qaadashada cannabinoid, waxayna shaqadeeda bayoolajiga ah ku mari doontaa dariiqyo kale, nidaaminta waxqabadka PPAR-α si ay u kiciso lipolysis. Oleoylethanolamide waa daawo suurtagal ah oo ka nabdoonaanta cayilka buurnida oo beddalanaya iska soo horjeedka CB1.

Daraasadaha horudhaca ah waxay muujiyeen in Oleoylethanolamide sidoo kale tahay wax ku ool ah anti-bararka iyo antioxidant-ka isku darka kaas oo u leh waxyeelada neuroprotective ee khamriga. Maamulka qotodheer ee Oleoylethanolamide wuxuu si wax ku ool ah uga hor tagi karaa aalkolada TLR4 ee dhexdhexaadka ah ee loo yaqaan 'TLRXNUMX', oo markaa yareynaysa sii deynta cytokines-ka proinflammatory iyo kiimikada, walaxda iyo walaaca dareeraha, iyo ugu dambeyntiina waxay ka hortagtaa dhaawaca neerfaha ee kilkilaha hore ee jiirka.

Muxuu qabtaa Oleoylethanolamide (OEA)?

Dadka cayilan, OEA waxay habeyn kartaa tamarta homeostasis iyo rabitaanka cuntada inteeda badan iyadoo ay kujiraan firfircooni soo dhaweynta kala duwan oo ay ka mid yihiin protinimal proliferator-activip receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) iyo receipor receipor recepor channel iman kara subfamily V (TRPV1). Runtii, OEA waxay shaqeysaa qaabilaadayaashan waxayna dib u dhigtaa bilowga cuntada, waxay yareysaa cabirka cuntada, waxay yareyneysaa inta udhaxeysa cunnooyinka ugu dambeyntiina waxay habeysaa miisaanka jirka.

Intaa waxaa dheer, qaar ka mid ah daraasadaha tijaabada ah ayaa muujinaya in OEA ay sidoo kale joojineyso muujinta IL-6, interleukin-8 (IL-8), isku-darka isku-dhafka unugyada-1 (ICAM-1) iyo unugyada unugyada vascular molecule-1 (VCAM-1) ee TNF -in kudhacday barar unugyada unugyada unugyada unugyada dhiiga unugyada unugyada unugyada unugyada unugyada jirka iyagoo u shaqeynaya soo dhoweeyeyaasha bararka. OEA waxay kaloo xannibtay marinka nukliyeerka kappa-B (NF-kB) jirka. Sahanka 'YT et al', OEA (50 µmol / L) wuxuu hor istaagay muujinta TNF-α ee VCAM-1 ee muujinta HUVEC.

Faa'iidooyinka Oleoylethanolamide (OEA)

Maaddaama loo yaqaan 'ceramidase inhibitor', oo ah agonist-ka daawada GPR119, Oleoylethanolamide wuxuu wax ku ool u yahay ka hortagga cudurada neurodegenerative, anti-atherosclerosis, apoptosis, xanuun joojinta, kordhinta dheef-shiid kiimikaadka jirka, iyo unugyada unugyada islet is. Ilaalinta iyo cudurada kale ee dheef-shiid kiimikaadka waxay leeyihiin saameyn difaac wanaagsan. Intaas waxaa sii dheer, waxay yareyn kartaa duxda jirka iyadoo la xakameynaayo rabitaanka cuntada, xakameeyo miisaanka, oo lagu gaaro miisaanka oo yaraada. Oleoylethanolamide sidoo kale waxay leedahay awooda lagu yareeyo bararka iyo heerarka kolesteroolka hoose.

Isticmaalka Oleoylethanolamide (OEA)

  • Phamaceutical field Ceyriyada cuntada
  • Gaetani S, Oveisi F, Piomelli D (2003). “Qaabaynta qaabka cuntada ee jiirka ee ay ku jirto dhexdhexaadiyaha lipid dhexdhexaadinta oleoylethanolamine”. Neuropsychopharmacology. 28 (7): 1311–6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Xeerka qaadashada cuntada ee oleoylethanolamine". Qolka. Mol. Nolosha Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). Kororka ka dib abaabulka oleoylethanolamine postprandial ee xiidmaha yar ee Burmese Python (Python molurus) ”. Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Sebtember 2008). “Doorka endocannabinoids iyo analooryadooda buurnida iyo cunno xumada”. Cun Miisaan Khiyaano. 13 (3): e42–8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: saamaynta ay ku leedahay isku gudbinta hypothalamic-yada iyo peut-yada mindhicirka ee nidaaminaya qaadashada cuntada. Neuropharmacology. (2011)

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