Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020

Oleoylethanolamide (OEA) waa soo-kiciyaha firfircoon ee firfircoon ee firfircoon ee firfircoon ee loo yaqaan 'alpha receptor alpha (PPAR-alpha) agonist. Waa …… ..

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Oleoylethanolamide (OEA) (111-58-0) fiidiyow

Oleoylethanolamide (OEA) (111-58-0) Faahfaahinta

 

Product Name Budada Oleoylethanolamide (OEA)
Magaca Kiimikada n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChikey BOWVQLFMWHZBEF-KTKRTIGZSA-N
dhoolla caddayntaada CCCCCCCCC = CCCCCCCCC (= O) NCCO
Formula kelli C20H39NO2
Miisaanka kelli 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Dhibicda Biyaha 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Boiling Point 496.4 ± 38.0 ° C (Saadaaliyay)
mugga 0.915 ± 0.06 g / cm3 (Saadaaliyay)
Color Budada cad
Skulayl daran -20 ° C
Ku adkaanshaha ethanol iyo DMSO Xalka
Codsiga Qeybta Phamaceutical; xirmooyin;

 

Guudmarka

Oleoylethanolamide (OEA) ama N-Oleoylethanolamide (OEA) waa molooliko laga sameeyay jirka, badiyaa laga helo xiidmaha. Caddaynta sii kordheysa waxay soo jeedineysaa in OEA ay u dhaqmi karto sidii astaamo nafsaani ah oo ka soo qeyb gasha xakamaynta dabeecadaha la xiriira abaalmarinta. Sidoo kale, waxaa lagu sifeeyay inuu yahay wakiilka si firfircoon u shaqeynaya oo yaraynaysa qaadashada cuntada iyo miisaanka jirka oo kordha.

 

Waa maxay Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) waa soo-kiciyaha firfircoon ee firfircoon ee firfircoon ee firfircoon ee loo yaqaan 'alpha receptor alpha (PPAR-alpha) agonist. Waa wax dabiici ah oo dhaca glycolamide oo leh waxyaabo kala duwan oo u gaar ah guryaha homeostasis sida xakameynta rabitaanka cuntada, firfircoonida ka hortagga bararka, kicinta lipolysis iyo qiiqa dufanka leh. Oleoylethanolamide waxaa loo tixgelin karaa hormoon dhidibka maskaxda mindhicirka. Boorashka, lowska, iyo budada kookaha ayaa ah ilaha cuntada ugu muhiimsan ee Oleoylethanolamide ee cuntada. Si kastaba ha noqotee, qadarka Oleoylethanolamide ee laga helo cuntooyinkan ayaa hooseeya (in ka yar 2 µg / g).

Maaddaama ay tahay dhexdhexaad firfircoon oo leh nafley, oleylethanolamide (OEA) waxaa lagu soo saaraa xiidmaha iyo unugyada kale, waxayna ku lug leedahay qaanuunka dheellitirka tamarta naasaha, xakameynta qaadashada cuntada iyo dheef-shiid kiimikaadka, sida waxay habeyn kartaa cuntada Vertebrate iyo culeyska jirka. Oleoylethanolamide waa aashitada ethanolamide ee dufanka leh (FAE), oo ah analog-ga analogam ee loo yaqaan 'endocannabinoid arachidonic acid ethanolamide (anandamide), iyo shaqeyste ka soo horjeedda anandamide. Waxaa xusid mudan in Oleoylethanolamide uu ka duwan yahay anandamide, way ka madax bannaan tahay soo-qaadashada cannabinoid, waxayna shaqadeeda bayoolajiga ah ku mari doontaa dariiqyo kale, nidaaminta waxqabadka PPAR-α si ay u kiciso lipolysis. Oleoylethanolamide waa daawo suurtagal ah oo ka nabdoonaanta cayilka buurnida oo beddalanaya iska soo horjeedka CB1.

Daraasadaha horudhaca ah waxay muujiyeen in Oleoylethanolamide sidoo kale tahay wax ku ool ah anti-bararka iyo antioxidant-ka isku darka kaas oo u leh waxyeelada neuroprotective ee khamriga. Maamulka qotodheer ee Oleoylethanolamide wuxuu si wax ku ool ah uga hor tagi karaa aalkolada TLR4 ee dhexdhexaadka ah ee loo yaqaan 'TLRXNUMX', oo markaa yareynaysa sii deynta cytokines-ka proinflammatory iyo kiimikada, walaxda iyo walaaca dareeraha, iyo ugu dambeyntiina waxay ka hortagtaa dhaawaca neerfaha ee kilkilaha hore ee jiirka.

 

Ilaha Oleoylethanolamide (OEA)

Waxaa jira laba ilo oo laga helo Oleoylethanolamide (OEA), mid wuxuu ka yimid dhirta dabiiciga ah, tan kalena waa si isku-dubarid ah sheybaarka.

Achyranthes Aspera, oo u dhashay Hindiya, Shiinaha iyo dalal kale oo badan oo Aasiya ah, ayaa la sheegay inuu ku jiro Oleoylethanolamide OEA. Dhibaatada dabiiciga-Oleoylethanolamide-dabiiciga ah ayaa ah in ay jirto kaliya soo saarista saamiga ayaa la heli karaa, 15: 1 waa shay caan ah, mana ahan sida ay u awood badan tahay macaamiisha ama soo-saareyaasha soo saare. Dabcan, way ka sarreyn kartaa, laakiin qiimuhu aad ayuu u sarreeyaa, sidaa darteed ma ahan wax la taaban karo in lagu soo saaro Oleoylethanolamide dabiiciga ah ee ballaaran.

Isha ugu weyn ee Oleoylethanolamide waxaa laga sameeyay oleic acid, waxaa loo adeegsaday horudhaca N-oleoyl-phosphatidylethanolamine, kaas oo markaa lagu nadiifiyey N-acyl-phosphatidylethanolamine-Select phospholipase D (PLD) si loo sii daayo OleoylethanAA.

Oleoylethanolamide waa dheef-shiid kiimikaad dabiici ah oo opic acid ah. Sidaa darteed, cunnooyinka ay ku dheehan tahay saliida loo yaqaan 'oic acid' ayaa ah isha tooska ah ee OEA.

 

Sidee ayuu Oleoylethanolamide (OEA) u shaqeeyaa?

Dadka cayilan, OEA waxay habeyn kartaa tamarta homeostasis iyo rabitaanka cuntada inteeda badan iyadoo ay kujiraan firfircooni soo dhaweynta kala duwan oo ay ka mid yihiin protinimal proliferator-activip receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) iyo receipor receipor recepor channel iman kara subfamily V (TRPV1). Runtii, OEA waxay shaqeysaa qaabilaadayaashan waxayna dib u dhigtaa bilowga cuntada, waxay yareysaa cabirka cuntada, waxay yareyneysaa inta udhaxeysa cunnooyinka ugu dambeyntiina waxay habeysaa miisaanka jirka.

Intaa waxaa dheer, daraasadaha tijaabooyinka qaarkood waxay muujinayaan in OEA ay sidoo kale xakameyso muujinta IL-6, interleukin-8 (IL-8), isku-dheelitirka isku-dheelitirka ee isku-xidhka-1 (ICAM-1) iyo molecule adhesion cell-1 (VCAM-1) ee TNF - α caabuq ku dhaca unugyada unugyada jirka ee xididada xudunta bini'aadamka iyada oo loo marayo firfircoonida qabtayaasha duufaanka. OEA sidoo kale waxay horjoogsatay dariiqa nukliyeerka kappa-B (NF-kB) ee jirka. Sahankii YT et al, OEA (50 µmol / L) wuxuu joojiyay muujinta TNF-α ee lagu soo rogay muujinta VCAM-1 ee HUVEC.

 

Faa'iidooyinka Oleoylethanolamide (OEA)

Budada Oleoylethanolamide (OEA) waxay kufiican tahay inay lumiso culeyska iyada oo ah xakamaynta rabitaanka cuntada waxayna taageertaa heerarka kolestaroolka caafimaadka leh ee dadka waaweyn.

 

Oleoylethanolamide (OEA) sidii xakamaynta rabitaanka cuntada

Yaraynta cuntada iyo yareynta qaadashada cuntada waa hab wax ku ool ah oo lagu xakameeyo dheellitirka tamarta iyo culeyska jirka. Maaddaama xakamaynta cunnadu ay tahay barta weyn ee koontaroolidda tamarta (cuntada) qaadashada, maareynta rabitaanka cuntada ayaa muhiim u ah xakameynta miisaanka jirka oo caafimaad qaba, gaar ahaan marka lagu daro xulashooyinka qaab nololeed ee miyir-qabka ah oo ay ka mid yihiin feejignaanta qaadashada cuntada habboon, kaabista cuntada, iyo jimicsiga.

Oleoylethanolamide supplement waxay ka caawineysaa habeynta dheef-shiid kiimikaadka, waxay gacan ka geysaneysaa xakameynta gaajada iyadoo loo diro fariimaha cuntooyinka xiisaha leh maskaxda waxaana loo muujiyey inay gacan ka geysaneyso hoos u dhigida triglyceride iyo heerka kolestaroolka dhiigga.

 

Oleoylethanolamide ee Maareynta dufanka jirka

OEA waa habab bedqaba oo nabdoon oo lagu xakameeyo rabitaanka cuntada iyo kharashka tamarta.

Saamaynta OEA ayaa marka hore la baaray maxaa yeelay waxay la mid tahay kiimiko kale, cannabinoid loo yaqaan anandamide. Cannabinoids waxay la xiriiraan geedka Cannabis, iyo anandamides-ka ku jira geedka (iyo marijuana) waxay kordhin karaan rabitaanka qofka ee cunnada fudud iyagoo kicinaya jawaabta quudinta. Sida laga soo xigtay Wikipedia, Oleoylethanolamide waa analoomide loo yaqaan 'endocannabinoid anandamide' oo analoog ah. In kasta oo OEA ay leedahay qaab kiimiko ah oo lamid ah anandamide, saamaynta ay ku leedahay cunida iyo maaraynta miisaanka ayaa kala duwan. Si ka duwan anandamide, OEA waxay si madaxbanaan u shaqeysaa wadooyinka xashiishadda cannabinoid, iyada oo nidaamineysa waxqabadka PPAR-to si ay u kiciso xanuunka lipolysis

 

Oleoylethanolamide jirdhiska

Qof kastaa wuxuu caafimaad ka raadsadaa jir dhiska jirdhiska. OEA waxay caan ku tahay jirdhiska jirka. Qeybaha kaabayaasha jirka laga dhisayo, TTA (tetradecylthioacetic acid) ayaa badanaa si isku mid ah loogu adeegsadaa oleoylethanolamide (OEA), labaduba waxay kaloo ka caawiyaan gubida dufanka iyo yareynta gaajada. TTA ayaa sidoo kale laga yaabaa inay aad u yabooho kahortaga dufanka, maxaa yeelay waxay umuuqataa inay gubto baruur ka madax banaan jimicsiga; Natiijooyinka horudhaca ahi waxay tusayaan in jirku si fudud ugu muuqdo inuu "iska saaro" dufanka laftiisa halkii uu u baahnaan lahaa inuu ku gubto dhaqdhaqaaqa jirka.

Oleoylethanolamide (OEA) waxay yareyneysaa triglycerides iyo kolestarol, iyo, oo ay weheliso cannabinoid antagonist, waxay joojineysaa miisaanka jirka oo waxay wanaajisaa dyslipidaemia moodooyinka xoolaha ee buurnaanta.

Intaa waxaa sii dheer, maamulka nidaamsan ee oleoylethanolamide ayaa la helay inuu beddelo gulukoosta homeostasis, iyo sidoo kale sii deynta insulin iyo calaamadda insulin ee labada hepatocytes iyo adipocytes.

Dib-u-sameynta qaar ayaa muujineysa in kaabista oleoylethanolamide ay saameyn togan ku leedahay walaaca, iyo raadad badan iyo caddeyn ayaa loo baahan yahay si loo taageero.

 

Sida loo isticmaalo Oleoylethanolamide OEA

 

OWaxyeelooyinka dawada leoylethanolamide

Oleoylethanolamide OEA waa wax ku cusub suuqa dheeriga, mana jiraan wax saameyn xun oo la soo sheegay. Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) wax walaac ah kama qabin amniga OEA. Nolol maalmeedka, oleoylethanolamide waa beddel aamin ah oo miisaan lumis ah, kaas oo loo isticmaalo in lagu qiimeeyo xaddiga catabolism ee mareenka caloosha, kaas oo ka caawinaya yareynta dufanka iyada oo aan waxyeello xun u keenin.

 

Oleoylethanolamide qiyaasta

Ma jiro qiyaasta daawada guud ee lagu taliyey ee loo yaqaan 'oleoylethanolamide' tan iyo kaabista oleoylethanolamide wali ma ahan kuwo caan ah oo marxaladdeeda hore. RiduZone wuxuu ahaa budada OEA ee ugu horreysa ee la sumadeeyo sanadka 2015.

Qiyaasta lagu taliyey oleoylethanolamide waa hal kabasho 200mg markii la qaato iyada oo aan wax isku dhafan

Cilmi baaris ayaa soo jeedineysa inaad sidoo kale hoos u dhigi karto ama aad u kordhin karto qiyaasta daawada maalin kasta iyadoo loo eegayo miisaankaaga jirka.

100mg qof 150lb ah

145mg qof 200lb ah

180mg qof 250lb ah

 

Codsiga Oleoylethanolamide (OEA)

Budada Oleoylethanolamide waxay u isticmaashay kaabista daryeelka caafimaadka, oo loo sameeyay kaabsal adag ama kiniin ah miisaanka oo luma.

 

Tixraaca:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Is-beddelka qaabka cunnada ee jiirka dhexdhexaadiyaha lipid anorexic oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

 

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Xeerka qaadashada cuntada ee oleoylethanolamine". Qolka. Mol. Nolosha Sayniska. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

 

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Kordhinta xilliga dambe ee abaabulka oleoylethanolamine ee xiidmaha yar ee Burmese Python (Python molurus)". Am J Physiol Regul Isku-darka Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

 

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Sebtember 2008). "Doorka endocannabinoids iyo analologyadooda buurnida iyo cunno xumida". Cun Culeyska Miisaanka. 13 (3): e42-8. PMID 19011363.

 

  • Serrano A, et al. Oleoylethanolamide: saamaynta ay ku leedahay isku gudbinta hypothalamic-yada iyo peut-yada mindhicirka ee nidaaminaya qaadashada cuntada. Neuropharmacology. (2011)