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NADP cusbada budada (24292-60-2)

Nicotinamide adenine dinucleotide phosphate (NADP +) waa cofactor loo isticmaalo falcelinta anabolic. Nic-Nicotinamide adenine ……


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

-Nicotinamide adenine dinocleotide fosfow cusbada cusbada (NADP cusbada disodium) Smamnuucista

Product Name -Nicotinamide adenine dinucleotide fosfow cusbo disodium cusbo (NADP cusbo cusbada)
Magaca Kiimikada NADP Disodium; Nadide foshate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium salt;
CAS Number 24292-60-2
InChikey UNRRSQIQTVFDLS-WUEGHLCSSA-L
dhoolla caddayntaada C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
Formula kelli C21H26N7Na2O17P3
Miisaanka kelli 787.37
Monoisotopic Mass 787.039342 g / mol
Dhibicda Biyaha 175-178 ° C
Color Yellow
Skulayl daran -20 ° C
Biyaha milmi > 50 g / L
Codsiga Coenzyme ee aerobic iyo oxidations anaerobic

Waa maxay β-Nicotinamide adenine dinucleotide phosphate cusbada disodium (NADP cusbada cusbada)?

Nicotinamide adenine dinucleotide phosphate (NADP +) waa cofactor loo isticmaalo falcelinta anabolic. salt-Nicotinamide adenine dinucleotide phosphate disodium salt waa cusbada disdium-ka ee NADP +, waa coenzyme muhiim u ah khamriga khamriga ee gulukooska iyo fuuq-baxa oxidative ashyaa kale. Oo waxay ku dhacdaa si ballaaran unugyada ku nool, gaar ahaan beerka.

Nicotinamide adenine dinucleotide phosphate (NADP) iyo NADPH waxay sameeyaan labo redox. NADPH / NADP saamiga ayaa nidaaminaya awoodda dib-u-soo-celinta intracellular, gaar ahaan jawaabta anaerobic, taas oo saamayneysa jawaabta dheef-shiidka ee jirka. Tusaalooyinku waa lipid iyo isku-darka aasaaska aashitada. NADP sidoo kale waa lammaane coenzyme ah oo ku jira nidaamyada kaladuwan ee loo yaqaan 'cytochrome P450 cytochrome' iyo hababka falcelinta oxidase / reductase sida nidaamka loo yaqaan 'thioredoxin reductase / thioredoxin system'.

NADPH waxay bixisaa dhimista u dhigma ficil celinta biosynthetic waxayna bixisaa saameyn redox ah si looga hortago sunta noocyada oksijiinta firfircoon (ROS), iyadoo dib loo soo nooleeyo guluf-ka (GSH). Waxaa sidoo kale loo isticmaalaa wadiiqooyinka anabolic-ka sida kolestaroolka isku-darka iyo dufanka xayrta ee loo yaqaan 'Chain kordhin'.

Intaa waxaa sii dheer, Nidaamka NADPH wuxuu sidoo kale mas'uul ka yahay abuurista xag-jiryo bilaash ah unugyada ka hortagga iyada oo loo marayo NADPH oxidase. Kuwaas xag-jirka ah ee bilaashka ah waxaa loo isticmaalaa in lagu baabi'iyo cudurada ku dhaca hab la yiraahdo neefsashada oo ku dhaca. Waa yareyn u dhiganta isha aashkadda cytochrome P450 hydroxylated aromatics, steroids, khamriga, iyo daroogada.

Codsiga ee β-Nicotinamide adenine dinucleotide fosfow cusbada disodium

Nicotinamide adenine dinucleotide phosphate (NADP) iyo NADPH waxay sameeyaan labo redox. NADP / NADPH waa coenzyme oo taageerta falcelinta redox iyada oo loo marayo gaadiidka elektarooniga ah ee adeegyo fara badan, gaar ahaan falcelinta anaerobic sida lipid iyo synthesis-ka nucleic acid. NADP / NADPH waa lamaane coenzyme ah oo ku jira nidaamyo kala duwan oo cytochrome P450 ah iyo hababka falgalka oxidase / reductase, sida nidaamka thioredoxin reductase / thioredoxin.

Enzymesyada kale ee u isticmaala NADP sidii coenzyme waa: Alcohol dehydrogenase: NADP ku tiirsan; Aromatic ADH: NADP ku tiirsan; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl gudbinta; Gulukoos dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP gaar ah; Isocitric dehydrogenase; Enzymesyada malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase iyo Succinic semialdehyde dehydrogenase.

Tixraaca:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Dheef-shiid kiimikaadka Dhiirrigelinta iftiinka NADP ee Dhirta. Wejiga hore ee Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Qaaxada necrotizing toxin waa NAD + iyo NADP + glycohydrolase oo leh sifooyin enzymatic kala duwan .J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Qeybinta, Baahinta, Farsamaynta Cilladaha Caloolada, iyo Waxqabadka jir ahaaneed ee Flavin-based elektron-Bifurcating NADH-Ku-saleysan Hoosaadka Ferredoxin: NADP + Oxidoreductase. Dhanka Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. “Qaab dhismeedka iyo shaqada NAD kinase iyo NADP phosphatase: enzymesyada muhiimka ah ee hagaya isku-dheelitirka maaddada NAD (H) iyo NADP (H)”. Biyoolaji, Bayoolaji, iyo Bayoolajiga. 72 (4): 919–30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. “Ilaalinta Xargaha Xarfaanta Enzyme-Coenzyme ee FAD iyo NADP ee Xiritaanka Adrenodoxin Yaraynta-Xaydhka Enzyme”. Journal of Molecular Evolution. 85 (5-6): 205-218. Bibcode: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

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