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N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

NACET (N-Acetylcysteine ​​ethyl ester) waa aasaaska unugyada unugyada dhiigga ee loo yaqaan 'cysteine ​​cysteine ​​cysteine' oo leh astaamo aan caadi aheyn oo farmashiyootis ah oo cajiib ah… ..


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

NACET (59587-09-6) Faahfaahinta

Product Name NACET (59587-09-6)
Magaca Kiimikada R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChikey MSMRAGNKRYVTCX-LURJTMIESA-N
dhoolla caddayntaada CCOC (= O) C (CS) NC (= O) C
Formula kelli C7H13NO3S
Miisaanka kelli 191.25
Monoisotopic Mass 191.061614 g / mol
Dhibicda Biyaha 44.1-44.5 ° C
Boiling Point 337.6 ± 32.0 ° C (Saadaaliyay)
mugga 1.138 ± 0.06 g / cm3 (Saadaaliyay)
Color Cadaan-cad
Codsiga Nootropics iyo dawooyinka caqliga leh, waxaa loo isticmaali karaa kor u qaadista xusuusta, diiradda, hal-abuurka, sirdoonka iyo dhiirrigelinta. Waxaa sidoo kale loo isticmaali karaa kabitaanka cuntada.

waa maxay NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) waa curiye cysteine-ka unugyada unugyada unugyada leh ee loo yaqaan 'cysteine ​​cysteine ​​cysteine' oo leh astaamo aan caadi aheyn oo farmashiyoolaji ah iyo awood la taaban karo oo antioxidantka. NACET waxay leedahay noolaha sare ee afka. Waa antioxidant xoogan iyo horudhac hodan ah oo ah GSH, kaas oo laxiriira aashitadeeda bilaashka ah ee N-acetyl -L way ka duwan tahay -cysteine ​​(NAC). NACET waa budo cad oo heerkulka qolka ka jira isla markaana si xor ah ugu milma biyaha iyo miraha dareeraha ah.

NAC waa astaamaha loo yaqaan 'cysteine'. Ilaa iyo 1970-meeyadii, waxaa loo isticmaalay in lagu daaweeyo bukaanka qaba xad-dhaafka acetaminophen-ka iyo cudurada neerfaha, waxaana loo suuq geeyay dawo iyo nafaqo dheeri ah. Marka la barbar dhigo NAC, NACET waxay leedahay lipophilicity sareeya iyo sifooyinka guryaha ee dawooyinka kimikada. Waxay leedahay awood ay ku beddesho NAC daweynta, sida wakiilka mucolytic, antioxidant, iibiyaha GSH, paracetamol antidote, iyo ugu yaraan Donor oo ah gudbiyaha cirfiidka H 2 S iyo wakiilka ilaalinta UV.

Intaa waxaa sii dheer, nukliyeerka xooggan iyo yaraynta suuragalka NACET ayaa sidoo kale lagu cadeeyay unugyada dhiigga cas cas ee aadanaha. Waxaa la helay inuu ku uruuray unugyada dhiigga cas cas ee bini-aadamka, si wax ku ool ah isaga caabbinta waxyeellada sunta ee ay keento hydroperoxides. Sidaa darteed, kartida NACET sida anti-nitrite-ka-hortagga antioxidant-ka ayaa aad uga badan tan NAC methemoglobinemia iyo oxidant kale oo xoog leh. Daraasad lagu sameeyay jiirka ayaa lagu ogaaday in NACET uu si dhakhso leh u nuugo NACET-ka markii NACET afka laga qaato. Waxay awood u leedahay inay gasho unugyada waxayna soo saartaa NAC iyo cysteine, oo kordhisa hydrogen sulfide (H (2) S) wareegga wareega. Waa musharax wanaagsan oo adeegsiga afka ah soo saare H (2) S ah,

Faa'iidooyinka NACET (N-Acetylcysteine ​​ethyl ester)

Maaddaama ay awood u leedahay antioxidantka, NACET waxay leedahay faa iidooyin waaweyn xagga caafimaadka aadanaha.

- Hagaajinta xaaladaha caafimaad ee badan isla markaana yaree calaamadaha cudurka maskaxda;

- Daaweynta xad dhaafka acetaminophen, ka ilaalinta kelyaha iyo beerka;

- Waxay wanaajisaa shaqada sanbabbada iyagoo yareynaya caabuqa isla markaana jabinaya xabka, taas oo yareynaysa cudurrada neef-mareenka.

- Dhiirrigelinta caafimaadka maskaxda adoo habeeya xakameynta 'glutamate' iyo kordhinta 'glutathione', waxaa loo isticmaali karaa in lagu daaweeyo cudurrada sida cudurka 'Alzheimer' iyo cudurka Parkinson;

- Hagaajinta bacriminta ragga iyo dumarka

- Waxay hagaajin kartaa shaqada iska caabbinta cudurro badan, ka hortag waxyeellada oxidative ee wadnaha, waxayna yareysaa halista cudurka wadnaha.

- Waxaa laga yaabaa inay xasiliso sonkorta dhiiga iyadoo yareyneysa caabuqa ku dhaca unugyada baruurta

Soo-jiidashada NAVE (N-Acetylcysteine ​​ethyl ester)

Sababta oo ah NACET waxay soo bandhigtay saameyn weyn oo ku saabsan cudurka maskaxda, cudur neef-mareenka iyo jirro maskaxeed, waxaa badanaa loo adeegsadaa daawo iyo cunno dheeri ah si loo ilaaliyo maskaxda, loo hagaajiyo waxqabadka maskaxda iyo jir ahaaneed, si kor loogu qaado xusuusta, garashada iyo waxqabadka isboortiga.

Tixraaca:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): waa cillad jilicsan oo unugyada cysteine-ka loo yaqaan 'cysteine ​​cell' oo leh astaamo aan caadi ahayn oo dawada loo yaqaan 'antioxidantant awood'. Farmashiyaha Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) iyo N-acetyl-L-cysteine ​​ethyl ester (NACET) -Carseine-ku saleysan murashaxiinta leh astaamo caafimaad oo gaar ah oo loogu talagalay isticmaalka afka sida MAYA, H2S iyo GSH soo-saareyaasha iyo sida antioxidants: Natiijooyinka iyo dulmarka guud. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Dib u eegis. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester sidii kobcinta GSH ee unugyada asaasiga ah ee unugyada unugyada asaasiga ah: Daraasad isbarbardhig ah oo lala sameeyo daroogooyinka kale. 2018 Okt; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) iyo N-acetyl-L-cysteine ​​ethyl ester (NACET) –I murashaxiinta daroogada ee ku saleysan cysteine ​​oo leh astaamo caafimaad oo gaar ah oo loogu talagalay isticmaalka afka ayaa ah MAYA, H2S iyo GSH soo-saareyaasha iyo sida antioxidants: Natiijooyinka iyo dulmarka guud. Journal of Falanqaynta Daawada. Cabbirka 8aad, Caddadka 1aad, Febraayo 2018, bogagga 1-9.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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