N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020

NACET (N-Acetylcysteine ​​ethyl ester) waa sheeko cusub oo lipophilic cell-permeable cysteine ​​ah oo leh astaamo aan caadi ahayn oo daawo-dhaqameed iyo cajiib ah… ..

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) fiidiyow

NACET (59587-09-6) Faahfaahinta

Product Name NACET (59587-09-6)
Magaca Kiimikada R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChikey MSMRAGNKRYVTCX-LURJTMIESA-N
dhoolla caddayntaada CCOC (= O) C (CS) NC (= O) C
Formula kelli C7H13NO3S
Miisaanka kelli 191.25
Monoisotopic Mass 191.061614 g / mol
Dhibicda Biyaha 44.1-44.5 ° C
Boiling Point  337.6 ± 32.0 ° C (Saadaaliyay)
mugga 1.138 ± 0.06 g / cm3 (Saadaaliyay)
Color Cadaan-cad
Codsiga Nootropics iyo dawooyinka caqliga leh, waxaa loo isticmaali karaa kor u qaadista xusuusta, diiradda, hal-abuurka, sirdoonka iyo dhiirrigelinta. Waxaa sidoo kale loo isticmaali karaa kabitaanka cuntada.

 

waa maxay NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) waa sheeko lipophilic cell-permeable cysteine ​​derivative leh muuqaal aan caadi ahayn oo farmashiyaha iyo awood antioxidant cajiib ah. NACET waxay leedahay bioavailability afka ah. Waa antioxidant xoog leh oo hodan ah oo GSH ah, oo laxiriira asiidhkeeda bilaashka ah ee N-acetyl -L way ka duwan tahay -cysteine ​​(NAC). NACET waa budada cad ee heerkulka qolka waana mid si xor ah ugu milmi kara biyaha iyo dareeraha dabiiciga.

NAC waa astaamaha loo yaqaan 'cysteine'. Ilaa iyo 1970-meeyadii, waxaa loo isticmaalay in lagu daaweeyo bukaanka qaba xad-dhaafka acetaminophen-ka iyo cudurada neerfaha, waxaana loo suuq geeyay dawo iyo nafaqo dheeri ah. Marka la barbar dhigo NAC, NACET waxay leedahay lipophilicity sareeya iyo sifooyinka guryaha ee dawooyinka kimikada. Waxay leedahay awood ay ku beddesho NAC daweynta, sida wakiilka mucolytic, antioxidant, iibiyaha GSH, paracetamol antidote, iyo ugu yaraan Donor oo ah gudbiyaha cirfiidka H 2 S iyo wakiilka ilaalinta UV.

Intaa waxaa dheer, Nucleophilicity-ka xoogga leh iyo yaraynta awoodda NACET ayaa sidoo kale lagu caddeeyay unugyada dhiigga cas ee aadanaha. Waxaa la ogaaday inay ku urursan tahay unugyada dhiigga cas ee aadanaha, iyadoo si wax ku ool ah uga hortageysa waxyeellada oksidheer ee ay keento hydroperoxides. Sidaa darteed, kartida NACET ee ah antioxidant ka-hortagga nitrite-ka ayaa aad uga weyn tan NAC methemoglobinemia iyo oksaydhyada kale ee xoogga leh. Daraasado lagu sameeyay jiirka ayaa lagu ogaaday in NACET ay si dhakhso leh uga nuugto NAC marka NACET afka laga qaato. Waxay awood u leedahay inay gasho unugyada ayna soo saarto NAC iyo cysteine, taas oo kordhinaysa hydrogen sulfide (H (2) S) wareegga wareegga. Waa musharax u wanaagsan isticmaalka afka sida soo saaraha H (2) S,

 

Faa'iidooyinka NACET (N-Acetylcysteine ​​ethyl ester)

Maaddaama ay awood u leedahay antioxidantka, NACET waxay leedahay faa iidooyin waaweyn xagga caafimaadka aadanaha.

- In kor loo qaado xaaladaha caafimaad ee badan lana yareeyo astaamaha cudurka maskaxda;

- Daaweynta xad-dhaafka acetaminophen, ilaalinta kelyaha iyo beerka;

- Waxay hagaajisaa shaqada sanbabada iyadoo yaraynaysa caabuqa iyo xabka oo dillaaca, iyadoo markaa yareyneysa cudurrada daba-dheeraada ee neef-mareenka.

- Kor u qaadida caafimaadka maskaxda adoo xakameynaya glutamate iyo ku darista glutathione, waxaa loo isticmaali karaa in lagu daaweeyo cudurada sida cudurka Alzheimers iyo cudurka Parkinson;

- In kor loo qaado taranka ragga iyo dumarka

- Waxaa laga yaabaa in la wanaajiyo shaqada difaaca jirro ee cuduro badan, laga hortago in oksidative waxyeello u geysto wadnaha, iyo in la yareeyo halista cudurka wadnaha.

- Waxaa laga yaabaa inuu xasiliyo sonkorta dhiiga iyadoo hoos u dhigeysa caabuqa unugyada baruurta

 

Soo-jiidashada NAVE (N-Acetylcysteine ​​ethyl ester)

Sababtoo ah NACET waxay muujisay saameyn weyn cudurka dhimirka, cudurada neef mareenka ee joogtada ah iyo cudurada maskaxda, waxaa badanaa loo isticmaalaa daawo ahaan iyo kaabis cunto si loo ilaaliyo maskaxda, loo hagaajiyo waxqabadka maskaxda iyo jirka, si loo xoojiyo xusuusta, garashada iyo waxqabadka cayaaraha.

 

Tixraaca:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): waa cillad jilicsan oo unugyada cysteine-ka loo yaqaan 'cysteine ​​cell' oo leh astaamo aan caadi ahayn oo dawada loo yaqaan 'antioxidantant awood'. Farmashiyaha Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) iyo N-acetyl-L-cysteine ​​ethyl ester (NACET) -Carseine-ku saleysan murashaxiinta leh astaamo caafimaad oo gaar ah oo loogu talagalay isticmaalka afka sida MAYA, H2S iyo GSH soo-saareyaasha iyo sida antioxidants: Natiijooyinka iyo dulmarka guud. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Dib u eegis. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester sidii kobcinta GSH ee unugyada asaasiga ah ee unugyada unugyada asaasiga ah: Daraasad isbarbardhig ah oo lala sameeyo daroogooyinka kale. 2018 Okt; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) iyo N-acetyl-L-cysteine ​​ethyl ester (NACET) –I murashaxiinta daroogada ee ku saleysan cysteine ​​oo leh astaamo caafimaad oo gaar ah oo loogu talagalay isticmaalka afka ayaa ah MAYA, H2S iyo GSH soo-saareyaasha iyo sida antioxidants: Natiijooyinka iyo dulmarka guud. Journal of Falanqaynta Daawada. Cabbirka 8aad, Caddadka 1aad, Febraayo 2018, bogagga 1-9.