Nikotinamide riboside chloride (NR-CL) (23111-00-4)

March 11, 2020

Nicotinamide riboside (NR) waa nicotinamide adenine dinucleotide (NAD +) fiitamiin horudhac ah. …… ah

 


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

 

Fiidiyaha Nikotinamide riboside chloride (NR-CL) (23111-00-4) fiidiyow

Daawada Nicotinamide riboside chloride (NR-CL) (23111-00-4) Smamnuucista

Product Name Nikotinamide riboside chloride (NR-CL) (23111-00-4)
Magaca Kiimikada NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Daawada Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium koloriin; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
CAS Number 23111-00-4
InChikey YABIFCKURFRPPO-IVOJBTPCSA-N
dhoolla caddayntaada C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Formula kelli C11H15ClN2O5
Miisaanka kelli 290.7002
Monoisotopic Mass 290.066949 g / mol
Dhibicda Biyaha N / A
Color cad
Skulayl daran -20 ° C Talaajo
Codsiga cuntada kaabis ah, qeybta dawooyinka

 

waa maxay Nicotinamide chloride riboside(NR-CL)?

Nikotinamide riboside (NR) waa fiitamiin hore loo yaqaan 'nicotinamide adenine dinucleotide' (NAD +) oo laga helo fitamiin hore. Qaabka loo yaqaan "crystalline form of NR chloride" waxaa loo yaqaan NIAGEN, oo ah qaab isku-dhafan oo ah nikotiinamide riboside iyo isha laga helo nicotinamide ee nicotinic acid loo heli karo bioavia guud ahaanna waxaa loo arkaa mid nabdoon (GRAS). NR chloride waa mowduuca laba ogeysiis oo ka kooban noocyada cuntada, kuwaas oo inta badan loo isticmaalo cuntada.

Nicotinamide Riboside Chloride waa maado dabiici ah oo laga helo caanaha. Xaqiiqdii waxay la xiriirtaa niacin iyo noocyo kale oo fiitamiin B3 ah. Daraasadaha qaarkood waxay ogaadeen in Nicotinamide Riboside Chloride ay leeyihiin astaamo u gaar ah oo kobcin kara dheef-shiid kiimikaadka qofka si ay uga caawiso gubida kalooriyada badan iyo kahortagga miisaanka. Marka lagu daro miisaanka oo yaraada, waxay kaloo ka caawisaa kor u qaadista waxqabadka muruqyada, kordhinta kharashka tamarta, iyo yaraynta arrimaha halista u ah cudurka macaanka.

Sidoo kale, cilmi baaris lagu sameeyay aadanaha ayaa muujisay in labadaba Nicotinamide Riboside Chloride ay sare u qaadayaan heerarka NAD +, taasoo gacan ka geysaneysa in la xalliyo xaaladaha qaarkood ee da'da la xiriira, in kasta oo ay aad ugu dhakhsaha badan tahay in la ogaado weli sida uu waxtar u yeelan doono.

 

Faa'iidooyinka Nicotinamide chloride riboside(NR-CL)

Daawada 'Nicotinamide riboside chloride' waa qaab synthetic ah oo loo yaqaan 'nicotinamide riboside', faa'iidooyinkeeda / shaqadeedu waxay la mid tahay nicotinamide riboside. Waxay ka qaybqaadaneysaa dheef-shiid kiimikaadka jirka, waxaa loo isticmaali karaa in looga hortago cudurka 'pellagra' ama cudur kale oo nias goosasho ah iyo in la yareeyo kolestaroolka iyo triglycerides ee dhiigga ku jira. Waxaa sidoo kale loo isticmaalaa in lagu yareeyo halista wadne qabadka dadka qaba kolestaroolka sare ee horeyba u qabay wadna qabad Mararka qaarkood waxaa loo isticmaalaa in lagu daaweeyo cudurka halbowlayaasha wadnaha (atherosclerosis), wuxuu ilaaliyaa ilaalinta maskaxda iyo beerka (wadnaha, kaadi macaanka, cudurka Alzheimer).

Ka sokow, maadada loo yaqaan 'Nikotinamide rilorside chloride' sidoo kale waxay leedahay faa'iidooyin kale oo aadanaha ah:

  • Dheefshiidka si habboon iyo u nuugista borotiinnada iyo dufanka;
  • Caawinta u bedelida isku-dayga asaasiga ah ee amino acid tryptophan si loo niacin;
  • Yareeyaa mataga, oo yaree natiijooyinka qaadashada dawooyinka lidka ku ah dawooyinka lidka ku ah afka oo qalalan iyo kaadinta oo kugu adkaata;
  • Dhiirrigelinta isku-darka aasaaska aasaaska iyo ka hortagga gabowga unugyada iyo xubnaha, si loo gaaro ujeeddada dib-u-dhigga gabowga;
  • Muruqyada tartiib tartiib tartiib tartiib ah, curyaaminta murqaha iyo gacmaha iyo lugta neuritis;
  • Daaweynta hypometabolism-ka lagu dhasho iyo xoojinta dheef-shiid kiimikaadka;
  • Kahortagga iyo daaweynta fitamiin B6;
  • Daaweynta xanuunka loo yaqaan 'carpal tunnel syndrome';
  • Waxay ka caawisaa inuu lumiyo culeyska wuxuuna xoojiyaa shaqada murqaha.
  • Hagaajinta caabbinta jirka ee unugyada kansarka
  • Ka hortag lumis maqal
  • Waa diuretic dabiici ah.
  • Qaadashada qaadashooyin waaweyn waxay yareyn kartaa balwadda maandooriyaha waxayna saameyn wanaagsan ku leedahay kala-takhalusidda.
  • Hagaajinta shaqada unugyada laf-dhabarka, iyo sidoo kale howlaha unugyada kale ee jirka bini aadamka, si maqaarku u ifin.

 

Nicotinamide chloride riboside(NR-CL) isticmaal

Sababtoo ah Nicotinamide riboside chloride waxay leedahay astaamo caafimaad oo faa'iido leh, waxaa badanaa loo isticmaalaa nafaqeeyayaalka cuntada, daawada iyo beeraha feedstuff.

 

 

Tixraaca:

  • Conze D, Brenner C, Kruger CL. Badbaadada iyo Dheef-shiid kiimikaad ee Maamulka muddada-dheer ee NIAGEN (Nicotinamide Riboside Chloride) ee Randomized, Double-Blind, Plabo-control Clinical Trial of Healthy overweight Adult Adult. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
  • Bogan, KL, Brenner, C. (2008). "Nicotinic acid, nicotinamide, iyo nicotinamide riboside: qiimeyn molikal ah oo ah NAD + fiitamiinnada horudhaca ah ee nafaqada aadanaha". Annu. Rev. Nutr. 28: 115-130. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
  • Chi Y, Sauve AA (Nofeembar 2013). "Nicotinamide riboside, oo ah nafaqo raadraac ah oo ku jirta cuntooyinka, waa fiitamiin B3 oo leh saameyn ku yeelashada dheef-shiid kiimikaadka iyo neuroprotection". Daryeelka Curr Opin Clin Nutr Metab. 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.