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Nikotinamide riboside chloride (NR-CL) (23111-00-4)

Nikotinamide riboside (NR) waa fiitamiin hore loo yaqaan 'nicotinamide adenine dinucleotide' (NAD +) oo laga helo fitamiin hore. …….


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

Nicotinamide riboside chloride (NR-CL) (23111-00-4) Smamnuucista

Product Name Nikotinamide riboside chloride (NR-CL) (23111-00-4)
Magaca Kiimikada NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nikotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) chlorideum chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
CAS Number 23111-00-4
InChikey YABIFCKURFRPPO-IVOJBTPCSA-N
dhoolla caddayntaada C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Formula kelli C11H15ClN2O5
Miisaanka kelli 290.7002
Monoisotopic Mass 290.066949 g / mol
Dhibicda Biyaha N / A
Color cad
Skulayl daran -20 ° C Talaajo
Codsiga cuntada kaabis ah, qeybta dawooyinka

waa maxay Nicotinamide chloride riboside(NR-CL)?

Nikotinamide riboside (NR) waa fiitamiin hore loo yaqaan 'nicotinamide adenine dinucleotide' (NAD +) oo laga helo fitamiin hore. Qaabka loo yaqaan "crystalline form of NR chloride" waxaa loo yaqaan NIAGEN, oo ah qaab isku-dhafan oo ah nikotiinamide riboside iyo isha laga helo nicotinamide ee nicotinic acid loo heli karo bioavia guud ahaanna waxaa loo arkaa mid nabdoon (GRAS). NR chloride waa mowduuca laba ogeysiis oo ka kooban noocyada cuntada, kuwaas oo inta badan loo isticmaalo cuntada.

Nikotinamide Riboside Chloride waa maaddo dabiici ah oo laga helo caano. Runtii waxay la xiriirtaa niacin iyo qaabab kale oo fitamiin B3 ah. Baarayaasha qaarkood waxay ogaadeen in Nicotinamide Riboside Chloride ay leeyihiin astaamo u gaar ah oo kor u qaadi kara qofka dheef-shiid kiimikaadka si looga caawiyo gubitaanka kalooriyo badan kana hortagto korodhka miisaanka. Miisaan dhimista ka sokow, waxay sidoo kale gacan ka geysaneysaa kor u qaadista waxqabadka muruqyada, kordhinta kharashaadka tamarta, iyo yareynta waxyaabaha halista ah ee cudurka macaanka.

Sidoo kale, cilmi baaris lagu sameeyay aadanaha ayaa muujisay in labadaba Nicotinamide Riboside Chloride ay sare u qaadayaan heerarka NAD +, taasoo gacan ka geysaneysa in la xalliyo xaaladaha qaarkood ee da'da la xiriira, in kasta oo ay aad ugu dhakhsaha badan tahay in la ogaado weli sida uu waxtar u yeelan doono.

Faa'iidooyinka Nicotinamide chloride riboside(NR-CL)

Nikotinamide riboside chloride waa nooc jimicsi oo ah nicotinamide riboside, faa'iidooyinkiisa / shaqadeeda waxay la mid tahay nicotinamide riboside. Waxay qayb ka qaadataa dheef-shiid kiimikaadka jirka, waxaa loo isticmaali karaa in looga hortago cudurka 'pellagra' ama cudurka kale ee cudurka 'niacin' iyo hoos u dhigidda kolestaroolka iyo triglycerides-ga dhiigga. Waxaa sidoo kale loo isticmaalaa si loo yareeyo halista wadne istaagga ee dadka qaba kolestarool sare oo horey u lahaa wadne qabad. Mararka qaarkood waxaa loo isticmaalaa in lagu daaweeyo cudurka halbawlayaasha wadnaha (atherosclerosis), ka ilaalin maskaxda iyo beerka (wadnaha, kaadi macaanka, cudurka Alzheimer).

Ka sokow, maadada loo yaqaan 'Nikotinamide rilorside chloride' sidoo kale waxay leedahay faa'iidooyin kale oo aadanaha ah:

  • Dheefshiidka si habboon iyo u nuugista borotiinnada iyo dufanka;
  • Caawinta u bedelida isku-dayga asaasiga ah ee amino acid tryptophan si loo niacin;
  • Yareeyaa mataga, oo yaree natiijooyinka qaadashada dawooyinka lidka ku ah dawooyinka lidka ku ah afka oo qalalan iyo kaadinta oo kugu adkaata;
  • Dhiirrigelinta isku-darka aasaaska aasaaska iyo ka hortagga gabowga unugyada iyo xubnaha, si loo gaaro ujeeddada dib-u-dhigga gabowga;
  • Muruqyada tartiib tartiib tartiib tartiib ah, curyaaminta murqaha iyo gacmaha iyo lugta neuritis;
  • Daaweynta hypometabolism-ka lagu dhasho iyo xoojinta dheef-shiid kiimikaadka;
  • Kahortagga iyo daaweynta fitamiin B6;
  • Daaweynta xanuunka loo yaqaan 'carpal tunnel syndrome';
  • Waxay ka caawisaa inuu lumiyo culeyska wuxuuna xoojiyaa shaqada murqaha.
  • Hagaaji iska caabinta jirka ee unugyada kansarka
  • Ka hortag lumis maqal
  • Waa diuretic dabiici ah.
  • Qaadashada qaadashooyin waaweyn waxay yareyn kartaa balwadda maandooriyaha waxayna saameyn wanaagsan ku leedahay kala-takhalusidda.
  • Hagaajinta shaqada unugyada laf-dhabarka, iyo sidoo kale howlaha unugyada kale ee jirka bini aadamka, si maqaarku u ifin.

Nicotinamide chloride riboside(NR-CL) isticmaal

Sababtoo ah Nicotinamide chloride chloride waxay leedahay sifooyin daawo faa'iido leh, waxaa badanaa lagu isticmaalaa kaabisyada cuntada, daawada iyo goobta cuntada lagu quudiyo.

Tixraaca:

  • Conze D, Brenner C, Kruger CL. Badbaadada iyo Dheef-shiid kiimikaad ee Maamulka muddada-dheer ee NIAGEN (Nicotinamide Riboside Chloride) ee Randomized, Double-Blind, Plabo-control Clinical Trial of Healthy overweight Adult Adult. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
  • Bogan, KL, Brenner, C. (2008). "Nikotinic acid, nicotinamide, iyo nikotiinamide riboside: qiimeynta molikalikada ee NAD + fiitamiinnada hormarsan ee nafaqada aadanaha". Annu. Rev. Nutr. 28: 115-130. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
  • Chi Y, Sauve AA (Noofembar 2013). "Nikotinamide riboside, oo ah cunno nafaqo ku leh cuntooyinka, waa fiitamiin B3 oo saameyn ku leh dheef-shiid kiimikaadka iyo neuroprotection". Daryeelka Curr Opin Clin Nutr Metab Care. 16 (6): 657–61. doi: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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