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Pyrroloquinoline quinone (PQQ) (72909-34-3)

Pyrroloquinoline quinone (PQQ), oo sidoo kale loo yaqaan 'methoxatin', waa redox cofactor. Waxaa laga helaa ciidda iyo cuntada sida kiwifruit, sida …… ..


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Description

Pyrroloquinoline quinone (PQQ) (72909-34-3) Faahfaahinta

Product Name Quinone Pyrroloquinoline (PQQ)
Magaca Kiimikada Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChikey MMXZSJMASHPLLR-UHFFFAOYSA-N
dhoolla caddayntaada C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Formula kelli C14H6N2O8
Miisaanka kelli 330.21
Monoisotopic Mass 330.012415 g / mol
Barta Boliing 1018.6 ± 65.0 ° C (Saadaaliyay)
Barta Tooshka 569.8 ° C (1,057.6 ° F; 842.9 K)
mugga 1.963 ± 0.06 g / cm3 (Saadaaliyay)
Color Cajiin-guduud oranji
Heer kuleyl 2-8 ° C
milmi L. biyo
Codsiga PQQ ayaa loo soo sheegay inuu u shaqeeyo sidii biyo-u-biyo-macaan / sunta-biyaha iyo sidii antioxidant-ka. Waxaa sidoo kale loogu talagalay in lagu isticmaalo kaabisyada cuntada, sida tamarta, bedelka cuntada, iyo baararka la xoojiyay iwm.

waa maxay Quwadoneyaasha Pyrroloquinoline(PQQ)?

Pyrroloquinoline quinone (PQQ), oo sidoo kale loo yaqaan 'methoxatin', waa redox cofactor. Waxaa laga helaa ciidda iyo cunnooyinka ay ka midka yihiin kiwifruit, iyo sidoo kale caanaha naaska aadanaha. Pyrroloquinoline quinone waa pyrroloquinoline oo leh kooxaha oxo ee 4 - iyo 5-boos iyo kooxaha kaarboon labo-meelood 2, 7- iyo 9. Waxay leedahay door ahaan fitamiin Biyo-biyaheys ah iyo isku-duwaha. Iyo, waxay wakiil u tahay unugyada borotiinka ku lug leh kala sooca unugyada mammalian. Awoodda dib-u-warshadaynta sare ee PQQ ayaa laga yaabaa inay ku siiso kaalin dawadeed xagga ka-hortagga neurodegeneration iyo kansarka. (Sida wakiilka redox, Pyrroloquinoline quinone waa mid aad u deggan oo ka qaybqaadan kara boqolaal falcelin dheeraad ah oo ka badan antioxidant-ka kale, sida ascorbic acid, quercetin, iyo epicatechin.

Quinone-ka Pyrroloquinoline waa biofactor cusub, waxaana loo aqoonsaday bakteeriyada lafaha enzyme. Baadhitaano la sameeyay ayaa muujinaya in Quinone-ka Pyrroloquinoline laga yaabo inuu joogo inta lagu jiro fikirka noolaha hore iyo abuurista. Iyada oo ah awood koronto awood u leh, waxay kujirtaa koriinka xoolaha iyo bini aadamka. Quinone-ka Pyrroloquinoline ayaa la soo sheegay inuu ka qeybqaato howlo badan oo noolol ah oo leh faa'iidooyin muuqda oo badbaado ah (tusaale ahaan, kororka dhalashada carruurta iyo waxqabadka taranka) xoolaha.

Intaa waxaa dheer, Quinone-ka Pyrroloquinoline wuxuu leeyahay antioxidant iyo waxqabadka fiitamiin B-u eg, oo leh faa'iidooyin fara badan oo loogu talagalay maskaxda iyo jirka. Waxay kor u qaadaa caafimaadka garashada iyo xusuusta iyadoo lala dagaallamayo cillad la'aanta 'mitochondrial' iyo in laga ilaaliyo neerfayaasha waxyeelada sunta. Daraasadaha caafimaad ee bini-aadamka waxay muujiyeen in Pyrroloquinoline quinone ay kobciso xusuusta iyo mudada-gaaban, waxay wanaajiso dheef-shiid kiimikaadka iyo gabowga caafimaadka qaba, waxayna yareysaa astaamaha caabuqa, iyo sidoo kale hagaajinta dareenka guud ee wanaagsanaanta.

Sidee Pyrroloquinoline quinone(PQQ) shaqada?

Daraasadaha cimilada waxay muujinayaan wax ku ool ah muuqaalka firidhsan ee Pyrroloquinoline quinone ee dhiirrigelinta biogenesis mitochondrial. Hepatocytes Rat ee lagu sameeyay 'PQQ' 10-30 forM oo ah 24- 48 h ayaa lagu muujiyey “kororka loo yaqaan 'citrate synthase iyo cytochrome c oxidase', Mitotracker cufan, maadada DNA ee mitochondrial, iyo neefsashada oksijiinta unugyada. Wax ka qabashada hawshani waxay timid iyada oo la adeegsanayo firfircoonaanta borotiinka-isku-xidhka ka-jawaab-celinta ah ee CAMP (CREB) iyo peroxisome proliferator-firfircoon-receptor-γ coactivator-1α (PGC-1α), oo ah waddo caan ah oo lagu xakameeyo biogenesis mitochondrial. ” Daraasadaha vivo ee jiirka ayaa sidoo kale muujinaya saameyn wax ku ool ah kaabista cuntada ee ay weheliso PQQ (2mg PQQ / kg oo cunto ah). Kuwaas waxaa ka mid ah hoos udhaca Plasma triglycerides, kharashaadka tamarta oo kordha (oo la socda hepatic mitochondrial content), iyo hagaajinta dulqaadashada ischemia / dib-u-soo-kabashada. Moodooyinka tijaabada ah ee istaroogga iyo dhaawaca xudunta laf-dhabarta ayaa muujinaya in Pyrroloquinoline quinone ay yaraynayso dhimashada unugyada neuronal, qayb ahaan iyada oo loo yaqaan 'Pyrroloquinoline quinone' oo ilaalinaysa N-methyl-d-aspartic acid (NMDA). Moodooyinka Rat ee cudurka Parkinson waxay muujinayaan in kordhinta Quinone-ka Pyrroloquinoline ay yaraaneyso luminta neuronal, waxay kordhineysaa awoodda noocyada oksijiinta ee firfircoonaanta, waxayna ku fidisaa kahortaga hababka dheeraadka ah.

Faa'iidooyinka Quwadoneyaasha Pyrroloquinoline(PQQ) dheefaha

Maskaxda iyo Jirka, PQQ waxay leedahay faa iidooyin balaadhan.

- PQQ waxay taageertaa shaqeynta ugu habboon ee mitochondrial

Mitochondria waa kuwa soosaara tamarta unugyada waxayna door muhiim ah ka ciyaaraan caafimaadkeena guud. PQQ adiga oo ilaalinaya mitochondria jira isla markaana kor u qaada jiilka mitochondrial, markaa soo saar ATP (Tamarta). Firfircoonaan badan oo mitochondria, tamar badan.

- PQQ waxay taageertaa arrimaha koritaanka dareemaha

PQQ waxay kicineysaa soosaarka Xaqiiqda Kobcinta dareemeyaasha (NGF.), Waxay ilaalisaa oo dib u soo celisaa maskaxda dhaawacmey iyo unugyada dareemeyaasha, sidaa darteed waxay ka hortageysaa hoos u dhaca garashada (xusuusta luminta, barashada oo adkaata, iwm.) Da 'ahaan, faalig ama xannuunnada neerfaha, iyo waxay kor u qaadaan difaaca iyo antioxidant shaqooyinka, iyo kahortaga dhacdooyinka wadnaha iyo neerfaha.

- PQQ waxay ka hortagtaa walaaca fekerka

PQQ waxay bixisaa difaac antioxidant awood leh, waxay ka ilaalisaa unugyada jirka waxyeelada sunta oksida waxayna baabi'isaa xag-jiryada xorta ah. Waxay taageertaa dheef-shiid kiimikaadka dheef-shiid kiimikaadka iyo gabowga caafimaadka qaba, waxaana loo tixgeliyaa inay tahay isku-duwaha sheeko-yaqaannada cusub ee leh antioxidant iyo waxqabadka fiitamiin B-u eg.

Ka sokow, PQQ sidoo kale waxay lahaan kartaa ka hortag iyo daweynta dhaawaca beerka iyo shaqada daawada xinjirowga lidka ku ah.

Adeegsiga / isticmaalka Quwadoneyaasha Pyrroloquinoline(PQQ)

Daraasad 2009 ah oo lagu daabacay joornaalka caafimaadka ee Cunnada, Pyrroloquinoline Quinone ayaa lagu muujiyay inuu leeyahay awood uu ku caawiyo kahortaga. Waxaa loo istcimaalaa in lagu daaweeyo hoos u dhaca garashada (xusuusta oo luntay, dhibaatooyin xagga barashada ah, iwm.) Da 'ahaan, faalig ama xanuunada maskaxda, iyo kahortaga wadnaha iyo dhacdooyinka xanuunka maskaxda. Natiijooyin la mid ah ayaa lagu soo sheegay daraasad dabagal ah oo 2011 ah kaas oo Pyrroloquinoline Quinone sidoo kale si toos ah loogu siiyay kaabis cunto, sida cabbitaannada ku-saleysan cuntada caano ku saleysan.

Sida loo helo wax ku filan Quwadoneyaasha Pyrroloquinoline(PQQ)?

Nolosha, waxaad ka heli kartaa xoogaa PQQ qaar ka mid ah cuntooyinka sourse, waxay si dabiici ah u joogtaa cunno kala duwan iyo cabbitaanno ay ka mid yihiin basbaas cagaaran, dhir, shaah ama kiwifruit iwm. Si kastaba ha noqotee, haddii la tiriyo xaddiga cuntada ee qofku cuno maalin kasta, inta badan innaga midkeen kama heli karno PQQ ku filan cuntadeena maalinlaha ah. Sidaa darteed, haddii aad rabto faa'iidooyin intaa ka sii weyn, waxaad ku heli kartaa PQQ siyaabo kale siyaabo kale, sida kaabinta cuntada ee PQQ.

Tixraaca:

  • Dheecaan, Kelsey (12 Febraayo 2017). “Antioxidant-ka Dabiiciga ah Ayaa Ka Hortagi Kara Cudurka Beerka”. msn.com. Waxa la soo ceshaday 14 febraayo 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). Qufulka 'Pyrroloquinoline quinone: ka fogaanshaha methylotrophs iyo dhiirrigelinta kobaca ee microorganisms'. Biyo-xireyaasha 1 (1): 51-3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Bayoolaji: doorka PQQ sidii cofactor enzyme mammalian ah?". Dabeecad. 433 (7025): E10, doodo E11-2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Kooxda tuubada ah ee methanol dehydrogenase ee Hyphomicrobium X: caddeynta isbadalka elektaroonigga ee qaab dhismeedka quinone". Biyoolajiga Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quwadda-ku-tiirsaneyaasha fuuq-baxa ah ee bakteeriyada acetic acid.ppl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.


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