Budada Urolithin

Phcoker waxay awood u leedahay wax soo saar tiro badan iyo soo saarida urolithin a, urolithin b iyo Urolithin A 8-Methyl Ether oo ku jirta xaalada cGMP.

Waa maxay Urolithin A?

Urolithin A waa isugeyn dheef-shiid kiimikaad ah oo ka dhalata isbeddelka ellagitannins ee bakteeriyada mindhicirka. Waxay ka tirsan tahay fasalka xeryahooda dabiiciga ah ee loo yaqaan 'benzo-coumarins' ama 'dibenzo-α-pyrones'. Urolithin A waxaa loo soo bandhigay inuu kiciyo mitophagy iyo hagaajinta caafimaadka muruqyada xoolaha duugga ah iyo moodellada hore ee gabowga. Dhanka kale, waxaa sidoo kale la muujiyay inay ka gudubto xayiraadda maskaxda dhiigga, waxaana laga yaabaa inay yeelato saameyn neuroprotective ah oo ka dhan ah Cudurka Alzheimers.

Urolithin Budada waa badeecad dabiici ah oo leh waxqabadka antiproliferative iyo antioxidant. Urolithin A waxaa lagu sameeyaa dheef-shiid kiimikaad laga helo polyphenols oo laga helo lowska iyo miraha qaar, gaar ahaan rummaanka. Horudhacyadeeda - ellagic acids iyo ellagitannins - waa meel walba oo dabiiciga ah, oo ay ku jiraan dhirta la cuni karo, sida rummaanka, strawberries, raspberries, iniinka, shaaha iyo canabka muscat, iyo sidoo kale miraha kulaylaha badan.

Laga soo bilaabo 2000s, urolithin A waxaa lagu soo qaatay daraasado horudhac ah oo ku saabsan saameynteeda suurtagalka ah ee noolaha.

Sidee ayuu Urolithin A u shaqeeyaa?

Urolithin A waa urolithin, dheef-shiid kiimikaad microbial ah oo bini-aadam ah oo ka soo jeeda noocyada cunnada ee ellagic acid (sida ellagic acid) Dheef-shiid kiimikaadka mindhicirka ee bakteeriyada, ellagitannin iyo ellagic acid waxay u horseedaan sameynta urolithins Firfircoon A, B, C iyo D. Waxaa ka mid ah, urolithin A (UA) waa tan ugu firfircoon uguna waxtarka badan dheef-shiid kiimikaadka, kaas oo loo isticmaali karo inuu yahay anti-wax-ku-ool ah -billam iyo antioxidant.

Daraasadaha shaybaarka, waxaa la muujiyey in urolithin A ay keento mitochondria, taas oo ah soo kabashada xulashada ee mitochondria iyada oo loo marayo autophagy. Autophagy waa geedi socod looga saarayo mitochondria cillad leh dhaawaca ama walbahaarka ka dib, waana mid waxtar leh inta lagu jiro da'da. hoose iyo hoose. Saameyntan waxaa lagu arkay noocyada kala duwan ee xayawaanka (unugyada mammalian, jiirka iyo Caenorhabditis elegans).

Si kastaba ha noqotee, maxaa yeelay isha ellagitannin way ka duwan tahay, halabuurka koox kasta oo bakteeriya ah sidoo kale way ka duwanaan doontaa, sidaa darteed waxtarka u beddelashada urolithin A aad ayey ugu kala duwan tahay bini-aadamka, dadka qaarna waxaa laga yaabaa inaysan lahayn wax beddelaad ah.

Urolithin A faa'iidooyinka

Urolithin A (UA) waa cunno dabiici ah, dheef-shiid kiimikaad laga soo qaatay bulshada microbial. Waxay leedahay faa'iidooyin caafimaad oo kala duwan, oo ay ku jiraan yaraynta calaamadaha caabuqa, saameynta ka hortagga kansarka iyo xakameynta dufanka.

Maaddaama ay tahay dheef-shiid kiimikaadka ugu firfircoon uguna waxtarka badan, urolithin A (UA) waxay u shaqeyn kartaa sidii wax-ku-ool barar iyo antioxidant. Waxay sidoo kale kicin kartaa mitokondrial phagocytosis ee xayawaanka duugga ah iyo moodooyinka hore ee gabowga iyo hagaajinta caafimaadka muruqyada.

Urolithin A ma loo isticmaali karaa kaabis ahaan?

In 2018, Maamulka Cuntada iyo Dawooyinka ee Maraykanka ayaa u qaybiyay urolithin A inay tahay qayb badbaado leh oo ka mid ah cuntada ama alaabada dheeriga ah ee cuntada, oo leh qaddarro u dhexeeya 250 milligram ilaa 1 garaam halkii adeeg.

Ma jiraan waxyeellooyin Urolithin A ah?

Daraasadaha badbaadada ee dadka waayeelka ah waxay muujiyeen in urolithin A si wanaagsan loo dulqaadan karo. Daraasadaha vivo ma aysan go'aamin haddii ay jiraan wax sun ah ama waxyeelo gaar ah oo urolitin A.

Sidoo kale, badbaadada muddada-dheer ee kaabista Urolithin A iyo rummaanka lama yaqaan, inkasta oo daaweynta muddada-gaaban ee laga soosaaray rummaanka ay tahay mid ammaan ah.

Waa maxay Urolithin B? Budada Urolithin B?

Budada Urolithin B (CAS MAYA: 1139-83-9) waa urolithin, nooc ka mid ah xeryahooda phenolic ee laga soo saaray mindhicirka bini'aadamka ka dib markii la nuugo cuntada ay ku jiraan ellagitannins sida rummaanka, strawberries, casaanka casaanka, iniinta ama khamriga cas ee da'da . Urolithin B waxaa laga helaa kaadida oo ah qaab urolithin B glucuronide.

Urolithin B wuxuu yareeyaa xaalufka borotiinka wuxuuna kiciyaa murqaha jirka. Urolithin B wuxuu xannibayaa waxqabadka aromatase, enzyme oo ka hortagaya estrogen iyo testosterone.

Urolithin B waa wax soo saar dabiici ah oo leh firfircoonida antiproliferative iyo antioxidant. Urolithin B ayaa la muujiyey inuu ka gudbo caqabadda maskaxda ee dhiigga, waxaana laga yaabaa inuu yeesho saameyn neuroprotective ah oo ka dhan ah Cudurka Alzheimers.

Urolithin B waa dheef-shiid kiimikaad maaddada microbial-ka ah ee loo yaqaan 'ellagitannis' wuxuuna muujiyaa firfircooni firfircoon oo ka-hortagga sunta-jirka iyo dhaqdhaqaaqa ka-hortagga jirka ee ku xiran nidaamka deynta iyo shuruudaha. Urolithin B sidoo kale waxay soo bandhigi kartaa waxqabadka estrogenic iyo / ama waxqabadka anti-estrogenic.

Maxay Urolithin B u isticmaashaa? Faa'iidooyinka Urolithin B (UB)

Faa'iidooyinka Urolithin B:

Waxay kicisaa muruqyada borotiinka murqaha

Waxay yareysaa Burburka Barootiinka Muruqyada

Waxaa laga yaabaa inuu yeesho Saamaynta Muruqyada

Waxaa laga yaabaa inuu lahaado astaamaha anti-udugga

Urolithin B oo loogu talagalay murqaha

Urolithin B waxay yareyn kartaa dhaawaca muruqyada ee soo martay inta lagu gudajiro jimicsi xoog leh waxayna ka ilaalin kartaa murqaha culeyska ay sababaan cunnada dufanka badan. Daraasad caafimaad oo ku saabsan Urolithin B ee jiirarka ayaa ogaatay inay kordhisay korniinka myotubes iyo kala duwanaanshaha iyadoo la kordhinayo isugeynta borotiinka. Waxay muujisay awood ay ku xakameyneyso marinka loo yaqaan 'ubiquitin – proteasome way' (UPP), habka ugu weyn ee loo yaqaan 'catabolism protein'. Waxay kaloo kicisay dhiig karka muruqyada iyo yareynta muruqyada atrophy.

Marka la barbardhigo testosterone, Urolithin B markii lagu qaatey 15 uM waxay kordhisay waxqabadka soo dhoweynta androgen-ka 90% halka testosterone uu kaliya awood u leeyahay inuu fuliyo waxqabadka soo dhoweynta kordhay ee 50% at 100uM. Tan macnaheedu waa inay ku qaadato wax aad u yar Urolithin B si loo kordhiyo waxqabadka androgen ka si wax ku ool ah markaa qaddarka sare ee testosterone kaas oo kordhinaya waxqabadka androgen-ka si wax ku ool ah.

Intaa waxaa sii dheer, ugu waxtarka badan ee 15uM ee Urolithin B oo ah isugeynta borotiinka muruqyada weyn iyada oo loo marayo 96% marka la barbar dhigo 100uM ee insulin, taas oo ah isugeynta borotiinka muruqyada weyn ee ugu waxtarka badan 61%. Aamminaaddu waxay tahay in ay qaaddo wado dheer aad uga yar Urolithin B si loo dheereysto isku-darista borotiinka muruqyada oo leh heer sare oo wax ku ool ah.

Daraasadahaani waxay muujinayaan in Urolithin B ay xakameyn karto catabolism-ka protein-ka halka isla mar ahaantaana ay kordhiso isku-darka borotiinka, waa maaddo dabiici ah oo ka caawisa dhismaha muruqyada caatada ah iyadoo ka hortagaysa burburka murqaha.

Urolithin B waa mid ka mid ah dheef-shiid kiimikaadka caloosha ee ellagitannins, wuxuuna leeyahay saameyn anti-bararka iyo antioxidant. Urolithin B wuxuu joojiyaa waxqabadka NF-byB isagoo yareynaya fosforyaalka iyo hoos u dhaca IκBα, wuxuuna xakameynayaa fosforyaalka ee JNK, ERK, iyo Akt, wuxuuna kobciyaa fosforyaalka ee AMPK. Urolithin B sidoo kale waa jaangooyaha muruqa lafaha.

Waa maxay Urolithin A 8-Methyl Ether?

Urolithins waa dheef-shiid kiimikaad sarreeya oo aashitada loo yaqaan 'ellagic acid' oo laga keenay ellagitannins. Bini’aadamka ellagitannins waxaa loo beddelaa gut microflora oo loo beddelo aallad yar yar oo loo beddelo urolithins A, urolithin B, urolithin C iyo urolithin D xiidmaha waaweyn.

Urolithin A-8-Methyl Ether waa sheyga dhexdhexaadka ah inta lagu gudajiro isku-darka Urolithin A. Waa dheef-shiid kiimikaad sarreeya oo ah ellagitannin waxayna leedahay lahaanshaha antioxidant-ka iyo anti-bararka.

Sidee Urolithin A 8-Methyl Ether u shaqeeyaa?

(1) Waxyaabaha Antioxidant

Urolithin A 8-Methyl Ether wuxuu leeyahay saameyn antioxidant ah iyadoo la yareynayo xagjirnimada bilaashka ah, gaar ahaan hoos u dhigida heerka noocyada oksijiinta falcelinta leh (ROS) ee unugyada, iyo ka hortagga lipid peroxidation-ka noocyada unugyada qaarkood.

(2) Waxyaabaha anti-bararka

Urolithin A 8-Methyl Ether wuxuu leeyahay astaamo anti-bararka iyadoo la joojinayo soosaarka nitric oxide. Waxay si gaar ah u joojinayaan muujinta borotiinka loo yaqaan 'nitric oxide synthase' (iNOS) iyo mRNA oo keena caabuq.

Urolithin A 8-Methyl Ether faa'iidooyinka

Urolithin A 8-Methyl Ether waa badeecad dhexdhexaad ah oo ku jirta habka isku-dhafka ee Urolithin A, iyo dheef-shiid kiimikaad sare oo muhiim ah ee ellagitannin, oo leh antioxidant iyo anti-inflammatory properties. Maaddaama ay tahay dheef-shiid kiimikaad 'Urolithin A', waxay sidoo kale yeelan kartaa faa'iidooyin qaar ka mid ah Urolithin A:

(1) Wuxuu dheereyn karaa cimriga;
(2) Caawinta kahortaga kansarka qanjirka 'prostate';
(3) Kobcinta garashada;
(4) Suurtagalnimada miisaanka oo yaraada

Isticmaalka Urolithin A 8-Methyl Ether supplements?

Daawooyinka Urolithin A ayaa si fudud looga helaa suuqa iyada oo loo yaqaan 'ellagitannin' hodanka ah ee cuntada laga helo. Sida sheyga dheef-shiid kiimikaadka ee Urolithin A, Urolithin A 8-Methyl Ether sidoo kale waxaa loo isticmaali karaa in lagu daro.

Si kastaba ha noqotee, ma jiraan macluumaad badan oo ku saabsan macluumaad dheeri ah, waxaana loo baahan yahay cilmi baaris dheeraad ah.

Tixraaca:

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  2. Ryu, D. et al. Urolithin A wuxuu kiciyaa mitophagy wuxuuna sii dheereeyaa cimriga C. elegans wuxuuna kordhiyaa shaqada muruqyada jiirka. Nat. Med. 22, 879–888 (2016).
  3. "Ogeysiiska FDA GRAS GRN No. 791: urolithin A". Maamulka Cuntada iyo Dawooyinka ee Mareykanka. 20 Diseembar 2018. La soo celiyey 25 Ogosto 2020.
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  5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Qiimeynta amniga ee urolithin A, dheef-shiid kiimikaad oo ay soo saartay mindhicirka bini-aadanka bini-aadamka marka la cuno cunnooyinka dhirta laga soosaaray ellagitannins iyo ellagic acid" Cuntada iyo Kiimikada Sunta. 108 (Pt A): 289-297. doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.