α-ketoglutaric

Phcoker waxay awood u leedahay wax soo saar ballaaran iyo soo saaridda Kaalshiyamka 2-oxoglutarate iyo Alpha-Ketoglutaric Acid iyadoo la raacayo xaaladda cGMP.

Waa maxay magacyada kale ee loo yaqaan 'Alpha-ketgoglutaric acide' oo loo yaqaan?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alfa-Ceytagtagota d'Arginine, Alfa-Ceytaga , Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha KG, AAKG, AAGG -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alfa-Ketoglutarate, 2-Oxoglicic Ac Aashito.

Waa maxay Alpha-Ketoglutaric acid?

Alpha-ketoglutaric (AKG) waa asiidh dabiici ah oo muhiim u ah dheef-shiid kiimikaadka dhammaan amino acids-ka muhiimka ah iyo wareejinta tamarta gacanta ee wareegga asiidhka. Waa horudhac u ah glutamic acid, amino aan muhiim ahayn oo ku lug leh isku-darka borotiinka iyo nidaaminta heerarka gulukoosta dhiigga. Marka lagu daro L-glutamate, AKG wuxuu yareyn karaa heerarka ammonia ee laga sameeyay maskaxda, muruqyada iyo kilyaha, sidoo kale wuxuu gacan ka geysanayaa isu dheellitirka kiimikada nitrogen ee jirka iyo ka hortagga xad dhaafka nitrogen ee unugyada jirka iyo dheecaannada. Shakhsiyaadka leh qaadashada borotiinka sare, infekshannada bakteeriyada, ama dysbiosis-ka caloosha iyo mindhicirka waxay ka faa'iideysan karaan kaabis dheeri ah oo loo yaqaan 'AKG' si looga caawiyo isu dheellitirka heerarka ammonia iyo ilaalinta unugyada.

Dadka qaarkiis waxay qaataan alpha-ketoglutarate si loo hagaajiyo waxqabadka cayaaraha ugu sarreeya. Bixiyeyaasha nafaqada nafaqada fudud waxay sheeganayaan alfa-ketoglutaric acid inay noqon karto mid muhiim u ah cunno habboon iyo tababar loogu talagalay cayaaraha doonaya waxqabadka ugu sarreeya. Waxay ku saleysan yihiin sheegashadan daraasado muujinaya ammonia dheeraad ah oo jirka ku jirta waxay la midoobi kartaa alpha-ketoglutarate si loo yareeyo dhibaatooyinka la xiriira ammonia badan (sunta ammonia). Laakiin, illaa iyo hadda, daraasadaha kaliya ee muujiya alpha-ketoglutarate waxay yareyn kartaa sunta ammonia waxaa lagu sameeyay bukaanada hemodialysis.

Bixiyeyaasha daryeelka caafimaad ayaa mararka qaarkood siiya alpha-ketoglutarate xidid (IV) si looga hortago dhaawaca wadnaha oo ay sababaan dhibaatooyinka socodka dhiigga inta lagu jiro qalliinka wadnaha iyo ka hortagga murqaha burburka qalliinka ka dib ama dhaawaca.

Farsamooyinka waxqabadka ee Alpha-Ketoglutaric acid

Qaababka saxda ah ee wax looga qabanayo α-Ketoglutarate wali lama faah faahin. Qaar ka mid ah ficillada α-Ketoglutarate waxaa ka mid ah ku-shaqeynta wareegga 'Krebs' oo ah dhexdhexaad, fal-celinta transamination inta lagu guda jiro dheef-shiid kiimikaadka amino acids, sameynta glutamic acid iyadoo la isku daro ammonia, iyo yareynta nitrogen iyadoo la isku daro sidoo kale. Ku saabsan actions-Ketoglutarate ficilkiisa ammonia, waxaa la soo jeediyay in α-Ketoglutarate ay ka caawin karto bukaanada qaba akadeemiyada propionic kuwaas oo leh heerar sare oo ammonia iyo heerar hoose oo glutamine / glutamate dhiigooda. Sababtoo ah glutamate / glutamine endogenous waxaa laga soo saaraa α-Ketoglutarate, bukaanada propionic acidemia waxay liitaan wax soo saarka α-Ketoglutarate iyo kaabista α-Ketoglutarate waa inay hagaajiso xaalada bukaanadan. Dhowr daraasado kale oo tijaabo ah ayaa sidoo kale muujiyey in maamulka α-Ketoglutarate ee nafaqada waalidnimada ee la siiyo bukaannada qalliinka ka dib ay gacan ka geysteen yaraynta isku-darka yaraynta borotiinka muruqyada oo badanaa la arko qalliinka ka dib. Isku-darka muruqyada oo yaraaday waxaa loo maleynayaa inay ugu wacan tahay heerarka α-Ketoglutarate oo aad u hooseeya.

Alfa ketoglutaric acid (AKG) dheeri ah - Waa maxay faa iidooyinka Alpha ketoglutaric acid?

Alpha-Ketoglutarate (AKG) oo ah Kaabis Waxqabadka Ciyaaraha ah
Alfa ketoglutaric acid, ama Alpha-ketoglutarate waa wax soo saar ka mid ah mitochondria waxayna door muhiim ah ka cayaaraysaa u beddelka cuntada tamarta. Sidoo kale waa isha laga helo glutamine iyo glutamate. Muruqyada, glutamine iyo glutamate waxay xakameysaa burburka borotiinka waxayna kordhisaa isku-darka borotiinka.

Alpha-ketoglutarate wuxuu xoojiyaa sameynta lafaha. Waxay xakameysaa isku-darka kolajka ee suurtogalka ah iyadoo la kordhinayo tirada molikuyuullada loo heli karo isku-dhafka. Collagen waa qayb muhiim ah oo ka mid ah unugyada lafaha.

Alfa-ketoglutarate wuxuu kiciyaa soosaarka cunsur u eg insulin -1 iyo hormoonka koritaanka. Kuwani waa labadaba hormoonno nidaamiya dib-u-warshadaynta lafaha iyo sameynta unug cusub oo laf ah.

faa'iidooyinka alfa ketoglutaric acid ee gabowga
Daraasaduhu waxay muujiyeen in AKG ay daaweyn karto xaalado badan markii loo qaado sida lagu faray.

Si kastaba ha noqotee, waxaa jira calaamado kale oo sheegaya in Alpha-Ketoglutarate (AKG) laga yaabo inuu awood u leeyahay inuu ka caawiyo guryaha gabowga.

Hal daraasad oo ballaadhan oo lagu qabtay Machadka Buck ee Cilmi-baarista Da'da oo ay weheliso Ponce de Leon Health ayaa lagu ogaaday in caafimaadku hagaagay ilaa 60% daraasaddooda naasleyda.

α-ketoglutaric
AKG wuxuu kordhiyaa cimriga dadka waaweyn ee C. elegans. (A) AKG wuxuu dheereeyaa cimriga gooryaanka qaangaarka ah. (B) Qalooca-jawaab celinta saameynta AKG ee cimri dherer.
Intaa waxaa dheer, Ponce De Lon Health (PDL) waxay soo saartay warbixin tijaabo ah, warbixinta ayaa muujineysa in nus sano kadib, da'da jir ahaaneed ee maadooyinka ay hoos udhaceen isku celcelis 8.5 sano jir kadib markay qaateen alpha-ketoglutarate (AKG) oo kujirta shirkada.

Xeryaha kale, sida daroogada antipapiamycin iyo metformin ee daaweynta sonkorowga, waxay muujiyeen saameyn isku mid ah tijaabooyinka jiirka. Laakiin AKG waxaa si dabiici ah u sameeya jiir iyo jirkeena, waxaana horeyba loogu arkaa amaan inay cunaan maamulayaasha.

Waxyaabaha aan u baahannahay inaan fiiro gaar ah u yeelanno waa in alpha ketoglutaric acid saafi ah ay aad u acidic tahay oo aan fududeyn in la cuno. Kordhinta jirdhiska ee suuqa waxaa lagu daraa arginine-α-ketoglutarate (AAKG), qaybta ugu weyn ee ay ka mid tahay arginine, halka midka ay isticmaasho Ponce De Lon Health uu yahay α-ketoglutarate calcium.

Alpha-ketoglutarate sidoo kale wuxuu leeyahay astaamo difaaca jirka xoojiya
AKG sidoo kale waxaa loo yaqaan cunsur difaaca jirka waxayna door muhiim ah ka ciyaaraan dheef-shiid kiimikaadka guud ee jirka. Horey ayaa loo ogaa in AKG uu yahay isha muhiimka ah ee glutamine iyo glutamate, waxaa lagu qeexaa sida loo yaqaan 'glutamine homologue iyo derivative'. Jirka, waxaa loo beddelaa glutamine. Glutamine waxay kordhin kartaa heerarka unugyada dhiigga cad (macrophages iyo neutrophils) .AKG sida glutamine homologue wuxuu leeyahay astaamo difaaca jirka, wuxuu ilaalin karaa xannibaadda mindhicirka, wuxuu kordhin karaa unugyada difaaca jirka iyo howlaha neerfaha iyo fagocytosis, wuxuu yareynayaa wareejinta bakteeriyada ee vivo.

Tixraaca:

  1. Aussel C, Coudray-Lucas C, Lasnier E, et al. Qaadashada Alpha-Ketoglutarate ee fibroblasts-ka aadanaha. Qalabka Biol Int 1996; 20: 359-63.
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  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine iyo alpha-ketoglutarate waxay kahortagayaan hoos u dhaca kudhaca muruqyada urursanaan la'aanta ah waxayna saameyn ku yeeshaan isku-dhafka borotiinka kadib wadar bedelida sinta. Dheef-shiid kiimikaad 1995; 44: 1215-22.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alpha-ketoglutarate wuxuu ilaaliyaa isku-darka borotiinka iyo glutamine bilaash ah ee muruqyada muruqyada qalitaanka ka dib. Qalliinka 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, iyo al. The epigenome gabowday iyo dib u cusbooneysiinteeda [J]. Faallooyinka Dabeecadda Biyoolaji Unugyada Molecular, 2020, 21 (3).
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  7. Alpha-Ketoglutarate, Metabolite-ka Endogenous, wuxuu dheereeyaa cimriga wuxuuna cidhiidhiyaa cudurada jiirka duqoobay. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.